Publications by authors named "Fanny Giguere"
Sensory deprivation, especially hearing loss (HL), offers a valuable model for studying neuroplasticity in the human brain and adaptive behaviours that support the daily lives of those with limited or absent sensory input. The study of olfactory function is particularly important as it is an understudied aspect of sensory deprivation. This study aimed to compare the effects of congenital HL on olfactory capacity by using psychophysical tasks.
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- - Shh (Sonic Hedgehog) protein attracts commissural axons to the floor plate through a unique signaling method that involves the receptor Boc, which requires internalization into early endosomes for growth-cone turning.
- - The protein Numb plays a crucial role by binding to Boc, facilitating its internalization, which is essential for both in vitro growth-cone turning and in vivo guidance of commissural axons.
- - While another receptor, Ptch1, can also be internalized by Shh with the help of Numb, this interaction alone doesn’t trigger internalization or growth-cone turning without Boc, suggesting Boc is vital for the signaling process.