S100-EPISPOT: A New Tool to Detect Viable Circulating Melanoma Cells.

Metastatic melanoma is one of the most aggressive and drug-resistant cancers with very poor overall survival. Circulating melanoma cells (CMCs) were first described in 1991. However, there is no general consensus on the clinical utility of CMC detection, largely due to conflicting results linked to the use of heterogeneous patient populations and different detection methods.

Systemic sclerosis with normal or nonspecific nailfold capillaroscopy.

Background: In systemic sclerosis (SSc), a specific nailfold videocapillaroscopy (NVC) pattern is observed in 90% of cases and seems to be associated with severity and progression of the disease.

Objective: To describe the characteristics of SSc patients with normal or nonspecific (normal/nonspecific) NVC.

Methods: In a retrospective cohort study, clinical features and visceral involvements of 25 SSc cases with normal/nonspecific NVC were compared to 63 SSc controls with the SSc-specific NVC pattern.

Clinical and immunologic factors associated with bullous pemphigoid relapse during the first year of treatment: a multicenter, prospective study.

Importance: Although predisposing factors for bullous pemphigoid (BP) have been recently established, no clinical or immunologic factors have yet been identified to predict disease outcome.

Objective: To identify risk factors for BP relapse during the first year of treatment.

Design, Setting, And Participants: Multicenter prospective study of 120 consecutive patients with newly diagnosed BP in 8 French dermatology departments.