Publications by authors named "Fanny Domont"
Article Synopsis
- A study compared the effectiveness and safety of infliximab and cyclophosphamide as induction therapies for severe Behçet's syndrome involving major vascular or CNS issues.
- Infliximab showed a higher complete response rate (81%) compared to cyclophosphamide (56%), indicating it may be more effective.
- Additionally, infliximab had fewer adverse events (29.6%) compared to cyclophosphamide (64%), suggesting it may also be safer for patients.
Aims: To compare the safety and efficacy of methotrexate (MTX), mycophenolate mofetil (MMF) and azathioprine (AZA) in non-anterior sarcoidosis-associated uveitis.
Methods: Retrospective study including non-anterior sarcoidosis-associated uveitis according to the revised International Workshop on Ocular Sarcoidosis criteria. The primary outcome was defined as the median time to relapse or occurrence of serious adverse events leading to treatment discontinuation.
Uveitis in Behçet's disease (BD) is frequent (40% of cases) and is a major cause of morbidity. The age of onset of uveitis is between 20 and 30 years. Ocular involvement includes anterior, posterior, or panuveitis.
View Article and Find Full Text PDFNeutrophilic dermatosis and hidradenitis suppurativa in patients with Behçet's disease: A neutrophilic disease in the spectrum of autoinflammatory syndromes.
Semin Arthritis Rheum
August 2023
Article Synopsis
- This study examines the relationship between neutrophilic dermatosis (ND), hidradenitis suppurativa (HS), and Behçet's disease (BD), noting shared traits that suggest a common underlying cause.
- The research identified 20 patients (out of 1462 experiencing BD) with ND or HS, finding a relatively high occurrence of pyoderma gangrenosum (PG) among them, which highlights the unique clinical features and responses to treatment in these patients.
- Treatment options including colchicine, glucocorticoids, and various biologic therapies like anti-TNFα have shown promising results for managing refractory cases of ND and HS in the context of BD.
Introduction: Autoimmune/inflammatory rheumatic diseases (AIRDs) patients might be at-risk of severe COVID-19. However, whether this is linked to the disease or to its treatment is difficult to determine. This study aimed to identify factors associated with occurrence of severe COVID-19 in AIRD patients and to evaluate whether having an AIRD was associated with increased risk of severe COVID-19 or death.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to compare the relapse rates of sight-threatening noninfectious uveitis (NIU) in patients treated with either infliximab (IFX) or adalimumab (ADA).
- It observed 330 patients, noting that 13% experienced a relapse within 6 months, with IFX showing significantly lower relapse risk compared to ADA.
- Behçet disease was linked to better treatment outcomes, including higher complete response rates and lower relapse rates when treated with anti-TNF-α agents.
Article Synopsis
- The study aimed to investigate how effective biologic treatments (specifically anti-TNF-α agents and tocilizumab) are for patients with refractory uveitic macular edema, focusing on their ability to control inflammation and reduce corticosteroid use.
- In total, 204 adult patients participated, with those treated using anti-TNF-α agents showing a 46.2% response rate compared to 58.5% for those receiving tocilizumab.
- The results indicated that tocilizumab was significantly more likely to provide complete response, while both treatment options had similar relapse rates and adverse effects, with 20.6% of patients experiencing side effects.
Objective: To assess the spectrum and long-term outcome of patients with noninfectious aortitis.
Methods: We performed a retrospective multicenter study of 353 patients (median age at diagnosis was 62 [IQR 46-71] yrs and 242 [68.6%] patients were women) with noninfectious aortitis.
Psoriasis is a skin inflammatory condition for which significant progress has been made in its management by the use of targeted biological drugs. Detection of latent infection (LTBI) is mandatory before starting biotherapy that is associated with reactivation risk. Together with evaluation of TB risk factors and chest radiographs, tuberculin skin tests (TST) and/or blood interferon-γ-release assays (IGRA), like the QuantiFERON (QFT), are usually performed to diagnose infection.
View Article and Find Full Text PDFBackground: Various observations have suggested that the course of COVID-19 might be less favourable in patients with inflammatory rheumatic and musculoskeletal diseases receiving rituximab compared with those not receiving rituximab. We aimed to investigate whether treatment with rituximab is associated with severe COVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases.
Methods: In this cohort study, we analysed data from the French RMD COVID-19 cohort, which included patients aged 18 years or older with inflammatory rheumatic and musculoskeletal diseases and highly suspected or confirmed COVID-19.
Objective: To report the efficacy of rituximab plus belimumab in patients with refractory cryoglobulinemia vasculitis (CV).
Methods: Belimumab was administered intravenously at a dose of 10 mg/kg on days 0, 14, 28 and then every month in association with rituximab in 4 patients with refractory CV. Demographic, clinical and laboratory characteristics, treatment modalities and outcomes were recorded.
Non-infectious uveitis (NIU) represents one of the leading causes of blindness in developed countries. The therapeutic strategy aims to rapidly control intra-ocular inflammation, prevent irremediable ocular damage, allow corticosteroid sparing and save the vision, and has evolved over the last few years. Anterior NIU is mostly managed with topical treatment in adults.
View Article and Find Full Text PDFBackground: Neuro-ophthalmologic manifestations are uncommon in sarcoidosis. We aim to assess the prognostic factors and outcome of neuro-ophthalmic sarcoidosis.
Methods: We conducted a multicenter retrospective study on patients with neuro-ophthalmic sarcoidosis.
Purpose: Drug-induced uveitis is a rare but sight-threatening condition. We seek to determine the spectrum of drug-induced uveitis at the era of immune checkpoint inhibitors (ICI).
Methods: Retrospective pharmacovigilance study based on adverse drug reactions reported within VigiBase, the WHO international pharmacovigilance database.
Article Synopsis
- Behçet's disease (BD) is a chronic condition that often leads to dangerous blood clots, but the exact causes are not well understood; this study investigates the connection between neutrophil extracellular traps (NETs) and thrombosis in BD.
- By analyzing blood samples from BD patients and healthy individuals, researchers found that those with active BD had higher levels of NET components, suggesting that NETs may play a significant role in blood clotting issues associated with the disease.
- The findings indicate that targeting NETs could be a promising approach to reduce the risk of thrombosis in patients with BD, highlighting the need for potential new treatments.
Objective: Oral ulcers, the hallmark lesion of Behçet's disease (BD), can be disabling and resistant to conventional treatment, and there is a need for safe and effective treatment. We undertook this study to investigate the long-term safety and efficacy of ustekinumab therapy for BD-related oral ulcers that are resistant to colchicine.
Methods: This multicenter, prospective, open-label study included 30 patients who fulfilled the criteria of the International Study Group for BD and who were diagnosed as having active oral ulcers resistant to colchicine.
Recurrent pericarditis is a frequent and troublesome complication of acute pericarditis. Aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) and colchicine are the mainstay of therapy but few data is available on second-line treatment. We retrospectively analyzed 13 patients, 7 females (54%), median age 40 years, with a median of 4 (IQR 1-6) recurrences per patient despite a well conducted first-line treatment and a median follow-up of 59 months (IQR 38-70).
View Article and Find Full Text PDFBackground: The neuro-ophthalmological manifestations of Behcet's disease (BD) are rare, and data regarding their characteristics and outcome are lacking.
Objective: To report prevalence, main characteristics and outcome of neuro-ophthalmological manifestations in BD.
Patients And Methods: This is a retrospective monocentric study of 217 patients diagnosed with neuro-Behçet's disease (NBD), of whom 29 (13.
Sarcoidosis is associated with cell-mediated immunodeficiency and treatment of symptomatic sarcoidosis usually includes systemic immunosuppressants. Data relative to incidence, prognosis factors, and outcome of infections are scarce.Retrospective cohort study of 585 patients with biopsy proven sarcoidosis in a tertiary referral specialist clinic, with a nested case-control analysis.
View Article and Find Full Text PDFObjective: The objective of this study was to describe large-vessel vasculitis (LVV) in patients with human immunodeficiency virus (HIV) infection. It is a retrospective single-center study conducted between 2000 and 2015 through a university hospital of 11 HIV-infected patients with LVV.
Methods: The characteristics and outcome of 11 HIV-infected patients with LVV (7 patients fulfilled international criteria for Takayasu arteritis, 5 patients had histologic findings of vasculitis, and 5 patients had imaging features of aortitis) were analyzed and compared with those of 82 patients with LVV but without HIV infection.
Objective: To describe the features of exceptional coexisting Takayasu arteritis (TA) and sarcoidosis, two conditions of unknown cause associated with a common immunologic pattern.
Methods: We report seven cases of concomitant sarcoidosis-Takayasu or Takayasu-like vasculitis, observed in two referral centers between 1995 and 2015.
Results: All patients were female.