Publications by authors named "Fanni Keresztes"
Article Synopsis
- Autophagy is a vital cellular process that declines with age, leading to accumulated damage and loss of cell function, particularly in neurons, which is linked to neurodegenerative diseases.
- Researchers are investigating ways to activate autophagy by enhancing the fusion of autophagosomes and lysosomes, with a focus on the role of small GTPase proteins like Rab2 and Rab7 in this process.
- Experiments showed that expressing active forms of Rab2 and Arl8 improved lifespan and motor functions in aging models, while Rab7 had negative effects, suggesting potential therapeutic targets for neurodegenerative conditions like Parkinson's disease.
Autophagy is a highly conserved self-degradation process of eukaryotic cells which is required for the effective elimination of damaged and unnecessary cytosolic constituents. Defects in the process can cause the intracellular accumulation of such damages, thereby leading to the senescence and subsequent loss of the affected cell. Defective autophagy hence is implicated in the development of various degenerative processes, including cancer, neurodegenerative diseases, diabetes, tissue atrophy and fibrosis, and immune deficiency, as well as in accelerated aging.
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