Comprehensive analysis reveals a 5-gene signature and immune cell infiltration in Alzheimer's disease with qPCR validation.

Over 50 million people around the world currently are suffering from Alzheimer's disease (AD) without any effective therapy. Neuroinflammation plays a pivotal role in AD, which leads us to probe the profile of immune cell infiltration in AD. Here, we analyzed a microarray dataset (GSE44770) containing 115 AD and 115 control samples to determine biomarkers and immune infiltration characteristics of AD by multiple bioinformatics methods.

Effects of wasp venom on venous thrombosis in rats.

Objectives: This study aimed to investigate the potential effects of wasp venom (WV) from on antithrombosis in rats with inferior vena cava (IVC) thrombosis.

Materials And Methods: The thrombosis rat model was established by improving the IVC stenosis, in which rats were subjected to IVC ligation for 75 min. Rats were administered argatroban (IP) or WV (s.

Wasp venom from acts as a neuroprotective agent to alleviate neuronal damage after stroke in rats.

Context: Acute ischaemic stroke (AIS) is a major cause of disability and death, which is a serious threat to human health and life. Wasp venom extracted from Smith (Vespidae) could treat major neurological disorders.

Objective: This study investigated the effects of wasp venom on AIS in rats.