Publications by authors named "Fanle Zeng"

Excessive acetaminophen (APAP) can induce neutrophil activation and hepatocyte death. Along with hepatocyte dysfunction and death, NETosis (a form of neutrophil-associated inflammation) plays a vital role in the progression of acute liver injury (ALI) induced by APAP overdose. It has been shown that activated neutrophils tend to migrate towards the site of injury and participate in inflammatory processes via formation of neutrophil extracellular traps (NETs).

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Article Synopsis
  • CCDC25 is found to be overexpressed in clear cell renal cell carcinoma (ccRCC) tissues and cell lines compared to normal tissues, indicating its potential role in cancer development.
  • Experiments showed that knocking down CCDC25 significantly inhibited tumor growth, migration, and invasion of cancer cells, while overexpressing it had the opposite effect.
  • The study suggests that CCDC25 interacts with integrin-linked kinase (ILK) to activate the NF-κB signaling pathway, making it a promising target for therapeutic interventions in ccRCC.
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Cistanche tubulosa (Schrenk) Wight, named Guan hua Rou Cong-Rong in Chinese, is a traditional plant with liver, kidney, and intestine protective effects. Echinacoside (ECH) is its active constituent and has been found to have various biological effects, including antioxidative stress and anti-inflammatory effects. Liver injury caused by acetaminophen or CCL has been proven to benefit from ECH; however, the effects of ECH against alcoholic liver disease (ALD) remain unclear.

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The health risk stemming from drinking alcohol is serious, sometimes even life-threatening. Alcoholic steatohepatitis (ASH) is a critical stage leading to cirrhosis and end-stage liver disease. However, its pathogenesis is still far from clearly understood, and a treatment that is widely recognised as effective has not been discovered.

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