Publications by authors named "Fangze Xing"
Article Synopsis
- * This study explored the connection between melatonin-related genes and osteoporosis using bioinformatics, identifying CSNK1D as a key gene involved in both circadian rhythm and osteoclastogenesis.
- * Experimental results showed that CSNK1D is critical for osteoclast differentiation and inflammation, indicating it may serve as a potential therapeutic target for osteoporosis treatments that focus on circadian rhythm regulation.
Article Synopsis
- Total hip arthroplasty (THA) is a surgical procedure that relieves pain and improves joint function in patients with end-stage hip conditions, but outcomes vary based on multiple factors.
- This research developed a predictive model using clinical data and radiomic characteristics from CT imaging to forecast postoperative joint function in patients who underwent robot-assisted THA (RA-THA), analyzing 136 patients divided into training and test sets.
- The study found that significant predictors included preoperative pain and function scores, and the combined model demonstrated high accuracy in predicting functional outcomes three years post-surgery, indicating potential for personalized treatment plans.
Computed tomography radiomics in predicting patient satisfaction after robotic-assisted total knee arthroplasty.
Int J Comput Assist Radiol Surg
June 2024
Article Synopsis
Background: Rotational alignment in total knee arthroplasty (TKA) is a crucial technical point that needs attention. We conducted a retrospective study to investigate whether a new robot-assisted TKA (RA-TKA) could improve the accuracy of rotational alignment and whether rotational alignment affects postoperative pain and functional evaluation of the knee.
Methods: A total of 136 consecutive patients who underwent TKA were included in this study.
Article Synopsis
- The study aims to understand the underlying mechanisms of osteonecrosis of the femoral head (ONFH) by analyzing differently expressed messenger RNAs (DE mRNAs) and immune cell infiltration in affected patients.
- Researchers utilized microarray technology and various bioinformatics methods to identify key genes related to ONFH and explore their biological functions through pathway enrichment and gene analysis.
- The results indicated 107 differentially expressed genes, with 76 downregulated and 31 upregulated, which were further validated for their roles in osteogenic differentiation and immune dysregulation.
Rheumatoid arthritis (RA) is an inflammatory disease which causes severe pain and disability. Neutrophils play essential roles in the onset and progression of RA; thus, inhibition of neutrophil activation is becoming a popular therapeutic strategy. Dehydroandrographolide has provided satisfactory outcomes in inflammatory diseases; however, its therapeutic effects and mechanism in RA are not fully understood.
View Article and Find Full Text PDFInflammatory bone destruction has gradually attracted attention worldwide and has been observed in several kinds of pathological bone diseases, such as osteoarthritis, osteomyelitis, rheumatic arthritis, and other infectious clinical trials in the skeletal system. In this regard, excessive osteoclasts and bone resorption activity participate in osteolytic processes. Thus, negatively modulating osteoclast differentiation and bone erosion has been considered an effective therapeutic strategy to limit the poor progression of inflammatory osteolysis.
View Article and Find Full Text PDFBackground: Osteoporosis is a disease threatening the health of millions of individuals. Melatonin is found to be a potential anti-osteoporosis drug. However, whether melatonin plays a role against osteoporosis at different stages of the menopause and the underlying mechanisms are unknown.
View Article and Find Full Text PDFIn our previous study, we reported that the long noncoding RNA, LMO7 downstream neighbor (LMO7DN), has a strong prognostic value in lung adenocarcinoma (LUAD). In this study, we further investigated the role of LMO7DN in LUAD progression. LMO7DN was found to be expressed at low levels in LUAD tissues, and its high expression predicted good prognosis.
View Article and Find Full Text PDF