Spatiotemporal connectivity maps abnormal communication pathways in major depressive disorder underlying gamma oscillations.

Auditory steady-state response underlying gamma oscillations (gamma-ASSR) have been explored in patients with major depressive disorder (MDD), while ignoring the spatiotemporal dynamic characteristics. This study aims to construct dynamic directed brain networks to explore the disruption of spatiotemporal dynamics underlying gamma-ASSR in MDD. This study recruited 29 MDD patients and 30 healthy controls for a 40 Hz auditory steady-state evoked experiment.

Neurophysiological markers of depression detection and severity prediction in first-episode major depressive disorder.

Objective: Deviant γ auditory steady-state responses (γ-ASSRs) have been documented in some psychiatric disorders. Nevertheless, the role of γ-ASSR in drug-naïve first-episode major depressive disorder (FEMD) patients remains equivocal. This study aimed to examine whether γ-ASSRs are impaired in FEMD patients and predict depression severity.

Altered fronto-central theta-gamma coupling in major depressive disorder during auditory steady-state responses.

Objective: Neural oscillations during sensory and cognitive events interact at different frequencies. However, such evidence in major depressive disorder (MDD) remains scarce. We explored the possible abnormal neural oscillations in MDD by analyzing theta-phase/gamma-amplitude coupling (TGC).

Hypofunction of directed brain network within alpha frequency band in depressive patients: a graph-theoretic analysis.

Directed brain networks may provide new insights into exploring physiological mechanism and neuromarkers for depression. This study aims to investigate the abnormalities of directed brain networks in depressive patients. We constructed the directed brain network based on resting electroencephalogram for 19 depressive patients and 20 healthy controls with eyes closed and eyes open.

Altered gamma oscillations and beta-gamma coupling in drug-naive first-episode major depressive disorder: Association with sleep and cognitive disturbance.

Objective: Gamma oscillations contribute to the pathogenesis mechanisms of major depressive disorder (MDD) have been proposed, but gamma activity is not well characterized. This study is the first attempt to investigate the altered gamma oscillations in first-episode MDD, particularly the beta-gamma coupling, and to determine the potential symptomatic relationship with the identified gamma dysregulation.

Methods: Resting electroencephalography was recorded for 43 drug-naive first-episode MDD and 57 healthy control (HC) subjects.

Alterations in Patients With First-Episode Depression in the Eyes-Open and Eyes-Closed Conditions: A Resting-State EEG Study.

Altered resting-state EEG activity has been repeatedly reported in major depressive disorder (MDD), but no robust biomarkers have been identified until now. The poor consistency of EEG alterations may be due to inconsistent resting conditions; that is, the eyes-open (EO) and eyes-closed (EC) conditions. Here, we explored the effect of the EO and EC conditions on EEG biomarkers for discriminating MDD subjects and healthy control (HC) subjects.