Adjuvants can enhance the immune effects of vaccines. Currently, the most commonly used and validated are aluminum and oil-emulsion adjuvants. However, these adjuvants are not without flaws; for instance, aluminum adjuvants can cause adverse reactions and irritation at the injection site.
View Article and Find Full Text PDFBackground: Antibiotic resistance of many bacteria, including Methicillin-resistant (MRSA), has become a major threat to global health. Zinc Oxide Quantum dots (ZnO-QDs) show good antibacterial activity, but most of them are insoluble in water, limiting their application range, and there is a lack of research on drug resistance inducement.
Methods: The water-soluble zinc oxide quantum dots modified by APTES (ZnO@APTES QDs) were prepared by a microwave assisted synthesis.
The ability to comprehend the intention conveyed through human body movements is crucial for effective interpersonal interactions. If people can't understand the intention behind other individuals' isolated or interactive actions, their actions will become meaningless. Psychologists have investigated the cognitive processes and neural representations involved in understanding action intention, yet a cohesive theoretical explanation remains elusive.
View Article and Find Full Text PDFMicroorganisms
September 2023
The type IV secretion system (T4SS) can promote the intracellular survival and reproduction of . T4SS secretes effector proteins to act on cellular signaling pathways to inhibit the host's innate immune response and cause a chronic, persistent infection. can survive in host cells for a long time by inhibiting macrophage apoptosis and avoiding immune recognition.
View Article and Find Full Text PDFAdvancing the practical application of catalytic oxidation technology demands for illustrating the synchronous conversion behavior of various volatile organic compounds (VOCs) over catalysts. Here, the mutual effects of benzene, toluene and xylene (BTX) were examined for their synchronous conversion on the surface of the MnO nanowire. Competitive adsorption of xylene (absorption energy (E): -0.
View Article and Find Full Text PDFCanine brucellosis is primarily caused by , but other species can also cause the disease. Identifying sequences specific to and establishing PCR assays that can distinguish between and other species is essential to determine the etiology of canine brucellosis and the source of infection and to achieve effective control. We analyzed the gaps and SNPs of genomes I and II from strain RM6/66 and strain 16M using the Mauve genome alignment software, and the specificity of each of these differential regions was analyzed by BLAST.
View Article and Find Full Text PDFBacterial infectious diseases cause serious harm to human health. At present, antibiotics are the main drugs used in the treatment of bacterial infectious diseases, but the abuse of antibiotics has led to the rapid increase in drug-resistant bacteria and to the inability to effectively control infections. Bacteriophages are a kind of virus that infects bacteria and archaea, adopting bacteria as their hosts.
View Article and Find Full Text PDFHarmful fungi in nature not only cause diseases in plants, but also fungal infection and poisoning when people and animals eat food derived from crops contaminated with them. Unfortunately, such fungi are becoming increasingly more resistant to traditional synthetic antifungal drugs, which can make prevention and control work increasingly more difficult to achieve. This means they are potentially very harmful to human health and lifestyle.
View Article and Find Full Text PDFis an important zoonotic pathogen that causes severe economic loss to husbandry and poses a threat to human health. The A19 live vaccine has been extensively used to prevent bovine brucellosis in China. However, it is difficult to distinguish the serological response induced by A19 from that induced by natural infection.
View Article and Find Full Text PDFAfrican swine fever (ASF) is a viral disease in swine that results in high mortality in domestic pigs and causes considerable economic losses. Currently, there is no effective vaccine or drugs available for treatment. Identification of new anti-ASFV drugs is urgently needed.
View Article and Find Full Text PDFPorcine circovirus type 3 (PCV3) is a novel pathogen first identified in the United States in 2016. As there is a high possibility that no clinical signs of infection are observed in the host, an accurate and sensitive method is needed for quarantine on numerous live pigs especially for international pig trade. In this study, a TaqMan-based real-time PCR assay specifically for PCV3 was established without cross-reactions with other non-targeted pig viruses.
View Article and Find Full Text PDFXi Bao Yu Fen Zi Mian Yi Xue Za Zhi
December 2018
Objective To prepare the monoclonal antibody (mAb) against the African horsefever virus (AHSV) VP7 protein and to identify it. Methods mAbs were prepared by using baculovirus expressed VP7 protein in BALB/c mice, and the effect of mAb was detected by ELISA, indirect immunofluorescence assay (IFA), and AHSV positive serum blockade. Results Four mAb strains were selected, including 20A8, 28B3, 30G8 and 47E6, among which 47E6 had the best blocking effect.
View Article and Find Full Text PDFBiochem Biophys Res Commun
April 2017
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
September 2016
Objective To explore the influence of the exogenous Jaagsiekte sheep retrovious (exJSRV) envelope protein (Env) on NIH3T3 cell proliferation. Methods A recombinant plasmid pcDNA4/myc-His/exJSRV- env carrying exJSRV- env gene was constructed, and then the correctness of the recombinant plasmid was identified by PCR, restriction enzyme digestion and sequencing. The recombinant plasmid pcDNA4/myc-His/exJSRV- env was transiently transfected into NIH3T3 cells by Lipofectamine(TM) LTX.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
February 2015
Two novel complexes [Cu(L)2(Ac)2]·3H2O (1) (L=N-2-methyl benzimidazole demethylcantharate imide, C16H15N3O3, Ac=acetate, C2H3O2) and [Cu(bimz)2(DCA)] (2) (bimz=benzimidazole, C7H6N2; DCA=demethylcantharate, C8H8O5) were synthesized and characterized by elemental analysis, infrared spectra and X-ray diffraction techniques. Cu(II) ion was four-coordinated in complex 1, Cu(II) ion was five-coordinated in complex 2. A large amount of intermolecular hydrogen-bonding and π-π stacking interactions were observed in these complex structures.
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