Publications by authors named "Fangyu Pan"
Article Synopsis
- SERPINA3K was found to have antioxidant properties in the cornea and was investigated for its effects on pterygial tissue, which is partly caused by oxidative stress.
- In laboratory tests, SERPINA3K treatment significantly reduced the proliferation and migration of cultured pterygial epithelial cells (PECs) compared to human conjunctival epithelial cells.
- The mechanism behind SERPINA3K's effects includes inhibiting the enzyme NOX4 related to reactive oxygen species (ROS) generation, increasing antioxidant levels, and down-regulating key components of the Wnt signaling pathway.
Purpose: To evaluate the anti-neovascularization effects and investigate the possible mechanisms of SERPINA3K, a member of serine proteinase inhibitor family, using a specific rat model of suture-induced corneal neovascularization. Methods: A rat corneal suture model was set up and SERPINA3K was topically administered three times daily for 7 days. The clinical indications were evaluated on day 2, 5 and 7, including area of neovascularization and inflammation index.
View Article and Find Full Text PDFPurpose: We recently reported that SERPINA3K (SA3K), a member of the serine proteinase inhibitor (SERPIN) family, has antiangiogenic and anti-inflammatory activities. Here we investigated the antioxidant effects of SA3K in the corneal epithelium and the mechanism underlying its action.
Methods: We established the oxidative stress models induced by hydrogen peroxide (H₂O₂) in cultured human corneal epithelial (HCE) cells and in rat corneal epithelium in vivo.