Exploring the interaction between calf thymus DNA and 11H-Indeno[1,2-b]quinoxalin-11-one Thiosemicarbazones: Spectroscopies and in vitro antitumor activity.

Understanding the interactions between small molecules and calf thymus deoxyribonucleic acid (ctDNA) is critical for certain aspects of drug discovery. In this study, three 11H-indeno[1,2-b]quinoxalin-11-one thiosemicarbazones were synthesized and their interaction with ctDNA was examined through various spectroscopic techniques, including ultraviolet (UV) spectroscopy, fluorescence spectroscopy, and circular dichroism (CD) spectrum, and through physicochemical methods, including viscosity measurements. In addition, the effects of these thiosemicarbazone compounds 4a, 4b and 4c on several cancer cell lines were explored.

The segmented flavivirus Alongshan virus reduces mitochondrial mass by degrading STAT2 to suppress the innate immune response.

Alongshan virus (ALSV) is a newly discovered pathogen in the family, characterized by a unique multi-segmented genome that is distantly related to the canonical flaviviruses. Understanding the pathogenic mechanism of this emerging segmented flavivirus is crucial for the development of effective intervention strategies. In this study, we demonstrate that ALSV can infect various mammalian cells and induce the expression of antiviral genes.

Amphiphilic sodium alginate-polylysine hydrogel with high antibacterial efficiency in a wide pH range.

Bacterial infection is a major pathological factor leading to persistent wounds. With the aging of population, wound infection has gradually become a global health-issue. The wound site environment is complicated, and the pH changes dynamically during healing.

Characterization of the complete chloroplast genome of .

The genus is one of the world's largest monocot genera. However, few reports on the complete chloroplast genome of plants are reported. In this study, we reported the complete chloroplast genome of .