Publications by authors named "Fangyi Shi"

Background: Myasthenic crisis (MC) refers to rapid deterioration of myasthenia gravis (MG), affecting lung and bulbar muscles and causing breathing difficulties. Currently, efgartigimod has shown good therapeutic effects in patients with generalized myasthenia gravis (GMG). This retrospective real-world study explored the effectiveness of efgartigimod in patients with MC.

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  • Lithium-sulfur batteries (LSBs) are promising next-gen rechargeable batteries thanks to their high energy density and low-cost sulfur cathodes, but they face challenges with insulation of sulfur particles at low temperatures.
  • The study focuses on the generation of liquid sulfur droplets in LSBs and reveals that their formation during the polysulfide oxidation reaction is consistent across various electrolyte/sulfur (E/S) ratios and temperatures.
  • Findings suggest that the sulfur oxidation reaction exhibits pseudo-zero-order kinetics and specific reaction constants that vary with E/S ratios, showing that liquid sulfur can be maintained even in extreme conditions like -20 °C.
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Background: The prevalence of patients positive for muscle-specific kinase antibody (hereafter, MuSK-Ab) accounts for 5-8% of all myasthenia gravis (MG) cases. Currently, efgartigimod has shown good therapeutic effects in MUSK-Ab-positive MG patients in a phase III clinical trial. However, phase III clinical trials tend to exclude MG patients in exacerbation, and there are only few real-world studies on the efficacy of efgartigimod in MuSK-Ab-positive myasthenic crisis (MC) patients.

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Engineering piezo/ferroelectricity in two-dimensional materials holds significant implications for advancing the manufacture of state-of-the-art multifunctional materials. The inborn nonstoichiometric propensity of two-dimensional transition metal dichalcogenides provides a spiffy ready-available solution for breaking inversion centrosymmetry, thereby conducing to circumvent size effect challenges in conventional perovskite oxide ferroelectrics. Here, we show the extendable and ubiquitous piezo/ferroelectricity within nonstoichiometric two-dimensional transition metal dichalcogenides that are predominantly centrosymmetric during standard stoichiometric cases.

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  • - A study on liquid sulfur in electrochemical cells has sparked further research into managing lithium-sulfur (Li-S) oxidation processes, particularly focusing on how sulfur transitions from liquid to solid.
  • - By observing sulfur generation on a graphene substrate and testing various current densities, a clear link was found between the size and quantity of liquid sulfur droplets and the current applied, while areal capacities were less affected.
  • - The findings suggest that using liquid sulfur in Li-S batteries can maintain nearly 100% capacity retention, even at high charging rates, paving the way for improved fast-charging sulfur cathodes and a deeper understanding of sulfur growth kinetics in Li-S battery systems.
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  • * A study screened nearly 5,000 plasma proteins and identified 1,216 influenced by body mass index, discovering nephronectin (NPNT) as a key protein linked to worse COVID-19 outcomes.
  • * NPNT was found to be expressed in lung cells of those who died from COVID-19 and was linked to increased illness severity, suggesting that managing body fat could lower NPNT levels and potentially improve COVID-19 outcomes.
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The electrochemical formation of liquid sulfur at room temperature on the basal plane of MoS has attracted much attention due to the high areal capacity and rapid kinetics of lithium-liquid sulfur chemistry. However, the liquid sulfur is converted to the solid phase once it contacts the solid sulfur crystals generated from the edge of MoS. Thus, stable liquid sulfur cannot be formed on the entire MoS surface.

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Ca-ion batteries (CIBs) have been considered a promising candidate for the next-generation energy storage technology owing to the abundant calcium element and the low reduction potential of Ca /Ca. However, the large size and divalent nature of Ca induce significant volume change and sluggish ion mobility in intercalation cathodes, leading to poor reversibly and low energy/power densities for CIBs. Herein, a polyanionic Na superionic conduction (NASICON)-typed Na-vacant Na V (PO ) F (N PVF ) with sufficient interstitial spaces is reported as ultra-stable and high-energy Ca ion cathodes.

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The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor known to mediate toxic responses to dioxin. However, the role of the AhR in the regulation of cellular physiology has only recently been appreciated, including its ability to control cell cycle progression and apoptosis by unknown mechanisms. We hypothesized that the AhR enhances the activation of the AKT serine/threonine kinase (Akt) pathway to promote cell survival.

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The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor whose physiological function is poorly understood. The AhR is highly expressed in barrier organs such as the skin, intestine, and lung. The lungs are continuously exposed to environmental pollutants such as cigarette smoke (CS) that can induce cell death mechanisms such as apoptosis, autophagy, and endoplasmic reticulum (ER) stress.

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Lithium sulfur batteries with high energy densities are promising next-generation energy storage systems. However, shuttling and sluggish conversion of polysulfides to solid lithium sulfides limit the full utilization of active materials. Physical/chemical confinement is useful for anchoring polysulfides, but not effective for utilizing the blocked intermediates.

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Atomic layered two-dimensional (2D) materials have become fascinating research topics due to their intriguing performances, but the limitation of nonmagnetic properties hinders their further applications. Developing versatile strategies endowing 2D materials with ferromagnetism is one of the main trends in current research studies. Herein, a hydrogen plasma strategy is introduced to dope hydrogen (H) atoms into the prototypical layered α-MoO nanosheets, by which ferromagnetic and exchange bias (EB) effects can be induced by H atom doping into α-MoO to form HMoO.

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