Publications by authors named "Fangyan Jia"
Article Synopsis
- Anti-double-stranded DNA (dsDNA) antibodies can harm the kidneys in people with a condition called systemic lupus erythematosus.
- Researchers looked at how a protein called TWEAK affects how these harmful antibodies get inside kidney cells.
- They found that TWEAK helps the antibodies enter the cells more easily and cause changes that can lead to kidney damage.
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) engagement with the receptor Fn14 contributes to the fibrotic process of kidney cells in systemic lupus erythematosus. Downregulation of the protein suppressor of cytokine signaling 1 (SOCS1) correlates with amplified production of proinflammatory factors and cell apoptosis, which participate in the pathogenesis of lupus nephritis. To elucidate the potential role of SOCS1 in TWEAK/Fn14 signaling, we determined the SOCS1 levels in primary kidney cells from MRL/MpJ (control strain) or MRL/lpr (lupus-prone) mice.
View Article and Find Full Text PDFRecently, increasing evidence showed that circular RNAs (circRNAs) play critical roles in tumor progression. However, the roles of hsa_circ_0062389 in non-small cell lung cancer (NSCLC) development remain unclear. In the present study, hsa_circ_0062389 expression was significantly increased in NSCLC tissues and cell lines.
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