Publications by authors named "Fangyan Hu"
Cytotoxic T lymphocytes (CTL) are pivotal in combating cancer, yet their efficacy is often hindered by the immunosuppressive tumor microenvironment, resulting in CTL exhaustion. This study investigates the role of interleukin-3 (IL3) in orchestrating antitumor immunity through CTL modulation. We found that intratumoral CTLs exhibited a progressive decline in IL3 production, which was correlated with impaired cytotoxic function.
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- The prevalence of Alzheimer's disease (AD) is rising, and current drugs cannot cure or slow it down.
- α-lipoic acid (LA), found in foods like spinach and meat, can potentially stabilize cognitive function in AD patients by reducing cell damage caused by the disease.
- The study shows that LA inhibits microglia toxicity and inflammation related to AD, suggesting a combination of anti-inflammatory and antioxidant treatments could be effective for managing the disease.
Mitochondria-associated endoplasmic reticulum membranes (MAMs) are dynamic suborganelle membranes that physically couple endoplasmic reticulum (ER) and mitochondria to provide a platform for exchange of intracellular molecules and crosstalk between the two organelles. Dysfunctions of mitochondria and ER and imbalance of intracellular homeostasis have been discovered in the research of toxics. Cellular activities such as oxidative stress, ER stress, Ca transport, autophagy, mitochondrial fusion and fission, and apoptosis mediated by MAMs are closely related to the toxicological effects of various toxicants.
View Article and Find Full Text PDFCalcium (Ca) is an essential signaling molecule in all cells. It is involved in numerous fundamental functions, including cell life and death. Abnormal regulation of Ca homeostasis may cause human diseases.
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- The increase in Alzheimer's disease (AD) due to a growing elderly population puts a strain on society and families, as the disease significantly affects patients' daily lives.
- Research showed that alpha-lipoic acid (LA) can reduce toxicity caused by amyloid beta fragments (Aβ) in PC12 cells, highlighting its potential therapeutic role.
- LA helps protect cells by preventing apoptosis and restoring the function of the Wnt-β-catenin signaling pathway, which is disrupted by Aβ treatment.