Tirzepatide attenuates mammary tumor progression in diet-induced obese mice.

We report for the first time an anticancer benefit of tirzepatide-a dual glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide receptor agonist-in a model of obesity and breast cancer in female mice. Long-term tirzepatide treatment induced weight loss, mitigated obesity-driven changes in circulating metabolic hormone levels, and suppressed orthotopic E0771 mammary tumor growth. Relative to tirzepatide, chronic calorie restriction, an established anticancer intervention in preclinical models, promoted even greater weight loss, systemic hormonal regulation, and tumor suppression.

Combined role of ground cover management in altering orchard surface‒subsurface erosion and associated carbon-nitrogen-phosphorus loss.

The combined role of ground cover management in controlling soil erosion and nutrient loss from new orchards is still less understood. In this study, four ground cover management practices, orchard with grass cover (OG), orchard with interplant cover (OI), orchard with straw cover (OS), and orchard with bare ground (OB), were designed to identify their impacts on soil erosion and associated carbon-nitrogen-phosphorus loss in new orchards by rainfall simulation tests with rainfall intensities of 60, 90, and 120 mm h and 90 min rainfall duration. The results showed that OS had the lowest surface flow coefficient (6.

Output characteristics and driving factors of non-point source nitrogen (N) and phosphorus (P) in the Three Gorges reservoir area (TGRA) based on migration process: 1995-2020.

Although physical models at present have made important achievements in the assessment of non-point source pollution (NPSP), the requirement for large volumes of data and their accuracy limit their application. Therefore, constructing a scientific evaluation model of NPS nitrogen (N) and phosphorus (P) output is of great significance for the identification of N and P sources as well as pollution prevention and control in the basin. We considered runoff, leaching and landscape interception conditions, and constructed an input-migration-output (IMO) model based on the classic export coefficient model (ECM), and identified the main driving factors of NPSP using geographical detector (GD) in Three Gorges Reservoir area (TGRA).

Spatiotemporal characteristics of air pollution in Chengdu-Chongqing urban agglomeration (CCUA) in Southwest, China: 2015-2021.

Studying the spatiotemporal characteristics of air pollutants in urban agglomerations and their response factors will help to improve the quality of urban living. In combining air quality monitoring data and wavelet analysis from the Chengdu-Chongqing urban agglomeration (CCUA), this study assessed the spatiotemporal distribution characteristics and influential factors of air pollutants on daily, monthly and annual scales. The results showed that the concentration of air pollutants in the CCUA has decreased year by year, and air quality has improved.

[Influence of Optimal Land Use Allocation on Phosphorus Loss in the Process of Rainfall and Runoff].

In order to explore the impact of optimized land use allocation on phosphorus loss in the runoff process of a small watershed in the Three Gorges Reservoir area, a traditional agricultural model catchment area (CG) and a catchment area after optimized land use allocation in the Shipanqiu watershed in Zhong County, Chongqing (EG) were selected as the research object, sampling at the outlets of the two catchment areas, respectively, to monitor the runoff process and different forms of phosphorus in rainfall events and to analyze the influence of land use configuration on the law of phosphorus loss. The results showed that:① in the 10 monitored rainfall and runoff processes, the [total phosphorus (TP)] of EG was lower than that of CG, and the ranges of the two were 0.09-0.

Denitrification performance and mechanism of biofilter constructed with sulfur autotrophic denitrification composite filler in engineering application.

Sulfur autotrophic denitrification (SAD) is a promising technology due to its low cost and low sludge production. Based on previous studies on SAD materials as well as the denitrification mechanism of SAD technology, this study constructed two biofilters with a sulfur autotrophic denitrification composite filler (SADCF) to investigate the application potential of SAD technology. The feasibility of a SADCF-based biofilter was demonstrated, with a maximum nitrate volume load of 0.

[Effects of Different Land Use Practices on Nitrogen Loss from Runoff During Rainfall Events].

To understand the effect of nitrogen from runoff during rainfall events for different land uses, sub-catchments A and B in the small Shipanqiu watershed in Zhong County, Chongqing-which were managed using different land use practices-were taken as research objects. Runoff flow and nitrogen levels at the outlet of the catchment were monitored. Sub-catchment A is an agroforestry-water complex and sub-catchment B is the site of traditional agriculture.

The RPA190-pc gene participates in the regulation of metalaxyl sensitivity, pathogenicity and growth in Phytophthora capsici.

Metalaxyl is one of the main fungicides used to control pepper blight caused by Phytophthora capsici. Metalaxyl resistance of P. capsici, caused by the long-term intense use of this fungicide, has become one of the most serious challenges facing pest management.

Degradation of nitrogen-containing refractory organic wastewater using a novel alternating-anode electrochemical system.

This study presented a novel alternating-anode electrochemical system (AAES) based on single electrolytic cell for the treatment of nitrogen-containing refractory organic wastewater (NOW). The core of AAES lies in the alternating working of iron anode and DSA anode to integrate different electrochemical processes. The biologically treated landfill leachate (BTLL) was selected as a practical NOW for assessing the performance of AAES.

Degradation of -nitrophenol by nano-pyrite catalyzed Fenton reaction with enhanced peroxide utilization.

Pyrite (FeS) catalyzed conversion of HO into oxidants is increasingly recognized as a promising Fenton-like process for treating recalcitrant contaminants. However, the underlying mechanism remains unclear, especially for nano-pyrite. The present study explored the potential of a nano-pyrite Fenton system for -nitrophenol oxidation using high energy ball milled nano-pyrite.

Treatment of polluted river sediment by electrochemical oxidation: Changes of hydrophilicity and acute cytotoxicity of dissolved organic matter.

River sediment is the main internal pollution source of water body. This study evaluated the feasibility of electrochemical oxidation (EO) for polluted river sediment treatment. The hydrophilic and acute cytotoxicity (ACT) of dissolved organic matter (DOM) during electrolysis were mainly investigated.

Research on complexation ability, aromaticity, mobility and cytotoxicity of humic-like substances during degradation process by electrochemical oxidation.

The humic-like substances were the main organic components in most wastewater (e.g. domestic sewage, toilet wastewater and landfill leachate).

Real-Time Curvature Detection of a Flexible Needle with a Bevel Tip.

As one of the major methods for the diagnosis and treatment of cancers in their early stages, the percutaneous puncture technique has bright prospect in biopsy, ablation, proximity radiotherapy, and drug delivery. Recent years, researchers found the flexible needle cannot realize feedback control during the puncture surgeries only by path planning. To solve this problem, the flexible needle is tried to achieve real-time detection in this paper.

A Friction-Inertial-Based Rotary Motor: Design, Modelling and Experiments.

A friction⁻inertial-based rotary motor driven by shear piezoelectric actuators (SPAs) is proposed in this paper, which possesses many superior features, including high resolution, compact size, large load-capacity, and low cost. In order to eliminate the step loss and increase the step size when an external load is applied, the power-function-shape driving signal was used to actuate the rotary motor. According to the step characteristics under this driving signal, two motion modes were observed and defined, namely the stick-shoot motion mode and the stick-slip-shoot motion mode.

Using biomarkers as fingerprint properties to identify sediment sources in a small catchment.

Traditional fingerprinting methods are limited in their ability to identify soil erosion sources where geologic variations are small or where different land uses span geological boundaries. In this study, a new biomarker for fingerprinting, specifically, n-alkanes, was used in a small catchment to identify sediment sources. The n-alkanes were based on land uses, could provide vegetation information, and were relatively resistant to diagenetic modifications and decomposition.

The nascent-polypeptide-associated complex alpha subunit regulates the polygalacturonases expression negatively and influences the pathogenicity of Sclerotinia sclerotiorum.

Sclerotinia sclerotiorum is a necrotrophic plant-pathogenic fungus that infects more than 400 species of plants. In this study the nascent polypeptide-associated complex α subunit gene of S. sclerotiorum (SsNACα; accession No.