Publications by authors named "Fangrui Zhu"
Mitochondria serve as the energy provider and enable life activities, and they are the only organelles containing extra-chromosomal DNA. Each mitochondrion contains multiple copies of its genome, which is usually referred to as mitochondrial DNA (mtDNA). mtDNA encodes necessary electron transport chain complex subunits, as well as the essential RNAs for their translation within the organelle.
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- The study identifies Nur77 as a new intracellular sensor for lipopolysaccharide (LPS) in macrophages, which is essential for NLRP3 inflammasome activation.
- Nur77 binds directly to LPS and forms a complex with mitochondrial DNA, highlighting its role in sensing bacterial components and signaling inflammation.
- The absence of Nur77 leads to reduced immune responses to endotoxins, suggesting its crucial function in the body's defense mechanism.
The NLRP3 inflammasome plays an essential role in resistance to bacterial infection. The nervous system secretes multiple neuropeptides affecting the nervous system as well as immune cells. The precise impact of the neuropeptide CGRP on NLRP3 inflammasome activation is still unclear.
View Article and Find Full Text PDFSARS-CoV-2 is an emerging coronavirus that causes dysfunctions in multiple human cells and tissues. Studies have looked at the entry of SARS-CoV-2 into host cells mediated by the viral spike protein and human receptor ACE2. However, less is known about the cellular immune responses triggered by SARS-CoV-2 viral proteins.
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