Glutamic-acid grafted hyaluronic acid inhibits inflammatory factors via fibroblast and skin model tests.

Background: Excessive inflammation may cause tissue damage and disrupt the function of the skin barrier. Hyaluronic acid (HA), an endogenous component, was found to regulate multiple inflammatory factors for skin health. This work aims to further enhance its efficacy by grafting amino acid onto its molecule.

Synergy of GHK-Cu and hyaluronic acid on collagen IV upregulation via fibroblast and ex-vivo skin tests.

Introduction: GHK-Cu and HA are two commonly used skin care ingredients, both of which were reported to enhance collagen synthesis. This work aims to investigate their co-effect on collagen regulation.

Materials And Methods: In cell experiments, human dermal fibroblasts were treated by a series of GHK-Cu and HA combinations, and the expressions of collagen I, IV, and VII were measured by qRT-PCR.

Synthesis of the cationic fluorescent probes for the detection of anionic surfactants by electrostatic self-assembly.

Anionic surfactants were widespread used in car cleaning agents, household detergents, agricultural and industrial processes, and considered as a major source of environmental pollutant. Therefore, it is necessary to develop a fast, simple, highly selective and sensitive probe for the detection of anionic surfactants. Here, we synthesized two aggregation induced emission (AIE)-active molecules 4,4',4″,4‴-(ethene-1,1,2,2-tetrayltetrakis(benzene-4,1-diyl))tetrakis (1-(4-bromobenzyl)pyridin-1-ium) bromide (TPE-Br) and 4,4',4″,4‴-(ethene-1,1,2,2-trayltetrakis(benzene-4,1-diyl))tetrakis(1-methylpyridin-1-ium)iodide (TPE-I), which were then applied as fluorescence probes for detecting sodium dodecyl sulfate (SDS) with high selectivity and sensitivity.

Synthesis, characterization, photophysics, and anion binding properties of platinum(ii) acetylide complexes with urea group.

A new class of platinum(ii) acetylide complexes with urea group, [Pt((t)Bu3tpy)(C[triple bond, length as m-dash]CC6H4-4-NHC(O)NHC6H4-4-R)](OTf) ((t)Bu3tpy = 4,4',4''-tri-tert-butyl-2,2':6',2''-terpyridine; R = H (), Cl (), CF3 (), and NO2 ()), has been synthesized and characterized. The crystal structures of , ·DMF·THF, ·CH3CN, and ·CH3CN have been determined by X-ray diffraction. Upon excitation at λ > 380 nm, the solid samples of complexes show orange light at 298 K.