Publications by authors named "Fangqing Cai"
Article Synopsis
- Renal cell carcinoma (RCC) is a prevalent and deadly form of cancer, with a significant portion of cases being the metastatic variant (mRCC), making treatment challenging; temsirolimus (TEM) is an approved therapy for advanced cases but has limitations due to poor water solubility and side effects.
- This study focused on creating a new drug delivery system using a block copolymer (mPEG-PBAE) to enhance the effectiveness of TEM through pH-responsive nanoparticles that release the drug in specific conditions.
- Results showed that the new micelles significantly improved TEM's water solubility, allowing for effective drug loading, a rapid release in acidic environments, and promising drug delivery properties without major toxicity issues.
Background: The escalating resistance of to macrolides has become a significant global health concern, particularly in low-income and middle-income countries (LMICs). Although tetracyclines and quinolones have been proposed as alternative therapeutic options, concerns regarding age-specific safety issues and the lack of consensus in recommendations across various national guidelines prevail. Thus, the primary objective of this study is to ascertain the most efficacious interventions for second-line treatment of .
View Article and Find Full Text PDFBackground: Novel β-lactams have in vitro activity against Pseudomonas aeruginosa (PA), but their clinical performances and the selection criteria for practical use are still not clear. We aimed to evaluate the efficacy of novel β-lactams for PA infection in various sites and to compare the efficacy of each agent.
Methods: We searched PubMed, Embase, Cochrane Library, and Web of Science for randomized controlled trials that used novel β-lactams to treat PA infection.