Association between IL-1 gene polymorphisms and tuberculosis susceptibility in the Chinese Tibetan population.

Interleukin-1 (IL-1) gene is known to be implicated in tuberculosis (TB). The present case-control study was designed to investigate whether IL-1 polymorphisms associated with TB susceptibility in a Chinese Tibetan cohort. 300 Tibetan tuberculosis patients and 300 healthy controls were recruited for 12 single-nucleotide polymorphisms (SNPs) genotyping of IL-1 gene via Sequenom MassARRAY analysis.

Vitamin D receptor gene associations with pulmonary tuberculosis in a Tibetan Chinese population.

Background: The vitamin D receptor (VDR) mediates the immunological function of vitamin D3, which activates macrophages, and vitamin D deficiency has been linked to tuberculosis risk. Single nucleotide polymorphisms (SNPs) in VDR may influence the function of vitamin D and susceptibility to tuberculosis.

Methods: This study included 217 patients with pulmonary tuberculosis (PTB) and 383 healthy subjects in a Tibetan Chinese population living in and near Xi'an.

[Change of brainstem auditory evoked potential with different stimulating frequencies after closed diffuse brain injuries of rat].

Unlabelled: OBJECTIVE To investigate the change of peak latency (PL), interpeak latency (IPL) and peak latency ratio (PL ratio) of brainstem auditory evoked potential (BAEP) with different stimulating frequencies after closed diffuse brain injuries of rat,and provide experimental evidence for clinical diagnosis of traumatic brain injury in early stage and also for Forensic practice.

Methods: A rat model for closed diffuse brain injury was successfully constructed by hit the parietal bone with a spring-driven steel stick. The auditory brainstem response (ABR) evoked by clicking with low stimulating frequency of 10 Hz and high stimulating frequency of 50 Hz were respectively recorded at 6 h, 12 h, 2 d, 4 d after brain injury.