A Novel High-Throughput Sample-in-Result-Out Device for the Rapid Detection of Viral Nucleic Acids.

Clustered regularly interspaced short palindromic repeats (CRISPR) molecular diagnostic technology is one of the most reliable diagnostic tools for infectious diseases due to its short reaction time, high sensitivity, and excellent specificity. However, compared with fluorescent polymerase chain reaction (PCR) technology, CRISPR molecular diagnostic technology lacks high-throughput automated instrumentation and standardized detection reagents for high sensitivity, limiting its large-scale clinical application. In this study, a high-throughput automated device was developed by combining reagent lyophilization, extraction-free technology, and a one-pot consumable system.

Intense emission at 605 nm from Pr-doped fluorotellurite glass fibers.

Pr-doped fluorotellurite glass fibers (PDFTFs) were fabricated by using a rod-in-tube method. By using a 976/1400 nm dual-wavelength upconversion pump technique, an intense emission at 605 nm was obtained from a 6 cm long PDFTF, which was attributed to the transition D→ H of Pr ions. With an increase in power of the 1400 nm laser from ∼34 to ∼136 mW, the spectral bandwidth of the 605 nm emission decreased and the intensity of the 605 nm emission increased monotonically, indicating the generation of 605 nm amplified spontaneous emission (ASE).

Endoscopic and clinicopathologic features of early gastric signet ring cell carcinoma ≤20 mm: a retrospective observational study.

Objectives: Limited literature exists on the characteristics of early gastric signet ring cell carcinoma (GSRCC) within 20 mm. This study aimed to explore this type of cancer from several aspects, to provide guidance for early detection and intervention of GSRCC.

Methods: We retrospectively collected data from 24 patients diagnosed with early GSRCC ≤20 mm in Beijing Friendship Hospital from 2016 to 2021.

Quality Care Alleviates Behavioral Cognitive Impairment and Reduces Complications in Elderly Patients with Cardiovascular and Cerebrovascular Diseases.

Objective: Cardiovascular and cerebrovascular disease (CCVD) remains the most common factor of death around the world. Nursing care plays a key role in the recovery of patients with CCVD. This study was to explore the application of quality care in aged patients with CCVD.

Disease-related and functional predictors of employment status among adults with multiple sclerosis.

Background: Due to the extent and complexity of its physical, cognitive, and psychological accompaniments, multiple sclerosis has tremendously negative effects on employment outcomes for adults with the disease.

Objective: This article extends the current understanding of the relationship between disease-related and functional factors and employment status among adults with multiple sclerosis.

Methods: Findings are reported in terms of descriptive statistics and logistic regression.

[The influence of laser induced damage points on characters of the laser transmission].

The production and increase of damage points in optical components under high energy repetitive pulsed lasers is closely dependent on the effects of light beam intensity modulation. In the present paper, the appearance of laser-induced damage points on surface of K9 glass was observed. The damage is increased toward center.