Publications by authors named "Fangling Deng"

Cu metalations of carbaporphyrins - gave the corresponding Cu complexes , , , and with varying degrees of distortions in Cu square-planar coordination. Upon treatment with Cu(OAc), was inert but and gave the respective O-atom-inserted complexes and . Further, and were converted to -methoxynickel(II) porphyrins and , respectively, via treatment with Cu(OAc) in methanol.

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2,7,12,17-Tetrakis(pinacolatoboryl) Ni porphyrin 5 Ni was synthesized in 75 % yield by Ir-catalyzed borylation of porphine followed by Ni metalation and has been demonstrated to be a useful synthon, giving 2,7,12,17-tetraaryated Ni porphyrins 6 a-d, peripherally octaarylated Ni porphyrins 8 a-d, quadruply bridged face-to-face non-offset Ni -porphyrin dimer 12, and cross-shaped β-meso singly linked porphyrin pentamers and nonamers. Oxidation of cross-shaped β-meso singly linked porphyrin pentamers 14 Ni and 14 Zn gave fused pentameric tapes 15 Ni and 15 Zn. The structures of 12, 14 Zn, and 15 Ni have been revealed by X-ray diffraction analysis.

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Hepatitis c virus (HCV) infection is one of major causes for chronic liver diseases worldwide and could lead to death. Development of effective HCV vaccines is a powerful auxiliary method of existing treatments. Adjuvants are necessary for modern vaccines to promote immune responses.

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The development of an intelligent biomaterial system that can efficiently accumulate at the tumor site and release a drug in a controlled way is very important for cancer chemotherapy. PEG is widely selected as a hydrophilic shell to acquire prolonged circulation time and enhanced accumulation at the tumor site, but it also restrains the cellular transport and uptake and leads to insufficient therapeutic efficacy. In this work, a PEG-detachable pH-responsive polymer that forms micelles from copolymer cholesterol grafted poly(ethylene glycol) methyl ether- D-poly(β-amino ester)- D-poly(ethylene glycol) methyl ether (MPEG- D-PAE- g-Chol) is developed to overcome the aforementioned challenges based on pH value changes among normal physiological, extracellular (pH), and intracellular (pH) environments.

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