Polar Vortices in Relaxor Ferroelectric Ceramics for High-Efficiency Capacitive Energy Storage.

Polar vortices are predominantly observed within the confined ferroelectric films and the ferroelectric/paraelectric superlattices. This raises the intriguing question of whether polar vortices can form within relaxor ferroelectric ceramics and subsequently contribute to their energy storage performances. Here, we incorporate 10 mol % CaSnO into the 0.

Distribution Characteristics of Low-Molecular-Weight Organic Acids in Reclaimed Soil Filled with Fly Ash: A Study.

This study aims to assess the contents of different kinds of low-molecular-weight organic acids (LMWOAs) in reclaimed soil filled with fly ash in the Huainan mining area in China using high-performance liquid chromatography (HPLC). Using a mobile phase consisting of 0.1% phosphoric acid and acetonitrile in a volume ratio of 98:2, the detection was performed at a wavelength of 210 nm for 15 min.

Effect of Low-Molecular Organic Acids on the Migration Characteristics of Nickel in Reclaimed Soil from The Panyi Mine Area in China.

This study investigated the effects of low molecular weight organic acids (citric acid and malic acid) on the migration properties of nickel in soil. A reclaimed soil sample was obtained from the Panyi Mine in Huainan City, China. The effects of adding different concentrations of Ni, citric acid (CA) and malic acid (MA) were assessed on the migration and transformation of soil Ni forms.

Mechanisms underlying the therapeutic effects of 4-octyl itaconate in treating sepsis based on network pharmacology and molecular docking.

Through network pharmacology and molecular docking technology, the hub genes, biological functions, and signaling pathways of 4-Octyl itaconate (4-OI) against sepsis were revealed. Pathological targets of sepsis were screened using GeneCards and GEO databases. Similarly, the pharmacological targets of 4-OI were obtained through Swiss TargetPrediction (STP), Similarity ensemble approach (SEA), and TargetNet databases.

Effect of Low-Molecular-Weight Organic Acids on Migration Characteristics of Pb in Reclaimed Soil.

The effect of low-molecular-weight organic acids (citric acid and malic acid) on the migration characteristics of Pb in contaminated soils was explored in this study. Reclaimed soil was collected from the coal gangue hill area of the Panyi mine in Huainan City (China). The effect of citric acid and malic acid on the form of Pb present in the reclaimed soil was analyzed by spiking soil samples and simulating Pb-contaminated soil.

Apelin-13 enhances contextual fear extinction in rats.

Fear extinction is considered as a new learning process that is valid to model features of post-traumatic stress disorder (PTSD). The neuropeptide apelin, such as apelin-13, apelin-17 and apelin-36, are endogenous ligands of the G-protein coupled receptor APJ. Apelin and its receptor APJ are widely distributed in the central nervous system.

The utility of folate receptor-positive circulating tumor cell in cancer diagnosis in the elderly population.

Cancer mortality is relatively high in the elderly population. Folate receptor-positive circulating tumor cell (FR+CTC) has proven an effective biomarker for diagnosis of lung cancer and bladder cancer and may be suitable for other cancer types accompanied with a high expression of FR. To date, the diagnostic efficiency of FR+CTC in the elderly population has not been systematically studied.

Role of the disulfide bond on the structure and activity of μ-conotoxin PIIIA in the inhibition of Na1.4.

μ-Conotoxin PIIIA, a peptide toxin isolated from , blocks the skeletal muscle voltage-gated sodium channel Na1.4 with significant potency. PIIIA has three disulfide bonds, which contribute largely to its highly constrained and stable structure.

Influences of disulfide connectivity on structure and antimicrobial activity of tachyplesin I.

Tachyplesin I is a potent antimicrobial peptide with broad spectrum of antimicrobial activity. It has 2 disulfide bonds and can form 3 disulfide bond isomers. In this study, the structure and antimicrobial activity of 3 tachyplesin I isomers (tachyplesin I, 3C12C, 3C7C) were investigated using molecular dynamic simulations, circular dichroism structural study, as well as antimicrobial activity and hemolysis assay.

Determination of the μ-Conotoxin PIIIA Specificity Against Voltage-Gated Sodium Channels from Binding Energy Calculations.

Voltage-gated sodium (Na) channels generate and propagate action potentials in excitable cells, and several Na subtypes have become important targets for pain management. The μ-conotoxins inhibit subtypes of the Na with varied specificity but often lack of specificity to interested subtypes. Engineering the selectivity of the μ-conotoxins presents considerable complexity and challenge, as it involves the optimization of their binding affinities to multiple highly conserved Na subtypes.

Application of reverse docking for target prediction of marine compounds with anti-tumor activity.

A large number of structures of anti-cancer drug targets have been solved and deposited to the protein data bank already. Identification of the targets for marine compounds with anti-tumor activity presents a challenge for marine natural products scientists. In this study, fast and efficient computational reverse docking was applied to predict the probable targeting proteins of the marine compounds with anti-tumor activity.

Discovery of DNA Topoisomerase I Inhibitors with Low-Cytotoxicity Based on Virtual Screening from Natural Products.

Currently, DNA topoisomerase I (Topo I) inhibitors constitute a family of antitumor agents with demonstrated clinical effects on human malignancies. However, the clinical uses of these agents have been greatly limited due to their severe toxic effects. Therefore, it is urgent to find and develop novel low toxic Topo I inhibitors.

Synthesis and Cytotoxicity against K562 Cells of 3-O-Angeloyl-20-O-acetyl Ingenol, a Derivative of Ingenol Mebutate.

Ingenol mebutate possesses significant cytotoxicity and is clinically used to treat actinic keratosis. However, ingenol mebutate undergoes acyl migration which affects its bioactivity. Compound 3-O-angeloyl-20-O-acetyl ingenol (AAI, also known as 20-O-acetyl-ingenol-3-angelate or PEP008) is a synthetic derivative of ingenol mebutate.