Endothelial dysfunction and disease severity in COVID-19: Insights from circulating Tang cell counts as a potential biomarker.

Background And Aim: Endothelial dysfunction is a common risk factor of severe COVID-19. Angiogenic T cells (Tang cells) play a critical role in repairing endothelial injury; however, their changes and potential roles in COVID-19 remain unclear. We aimed to assess Tang cell counts in patients with COVID-19 and evaluate their association with disease severity and prognosis.

Quasi-Ionic Liquid Enabling Single-Phase Poly(vinylidene fluoride)-Based Polymer Electrolytes for Solid-State LiNi Co Mn O ||Li Batteries with Rigid-Flexible Coupling Interphase.

Poly(vinylidene fluoride)-based polymer electrolytes are being intensely investigated for solid-state lithium metal batteries. However, phase separation and porous structures are still pronounced issues in traditional preparing procedure. Herein, a bottom-to-up strategy is employed to design single-phase and densified polymer electrolytes via incorporating quasi-ionic liquid with poly(vinylidene fluoride-co-hexafluoropropylene).

Diversion of metabolic flux towards 5-deoxy(iso)flavonoid production via enzyme self-assembly in .

5-Deoxy(iso)flavonoids are structural representatives of phenylpropanoid-derived compounds and play critical roles in plant ecophysiology. Recently, 5-deoxy(iso)flavonoids gained significant interest due to their potential applications as pharmaceuticals, nutraceuticals, and food additives. Given the difficulties in their isolation from native plant sources, engineered biosynthesis of 5-deoxy(iso)flavonoids in a microbial host is a highly promising alternative approach.

Improve the Biosynthesis of Baicalein and Scutellarein via Manufacturing Self-Assembly Enzyme Reactor .

Baicalein and scutellarein are bioactive flavonoids isolated from the traditional Chinese medicine ; however, there is a lack of effective strategies for producing baicalein and scutellarein. In this study, we developed a sequential self-assembly enzyme reactor involving two enzymes in the baicalein pathway with a pair of protein-peptide interactions in . These domains enabled us to optimize the stoichiometry of two baicalein biosynthetic enzymes recruited to be an enzymes complex.

Recent Advances in Metabolic Engineering, Protein Engineering, and Transcriptome-Guided Insights Toward Synthetic Production of Taxol.

The diterpenoid paclitaxel (Taxol) is a blockbuster anticancer agent that was originally isolated from the Pacific yew () five decades ago. Despite the wealth of information gained over the years on Taxol research, there still remains supply issues to meet increasing clinical demand. Although alternative Taxol production methods have been developed, they still face several drawbacks that cause supply shortages and high production costs.