Publications by authors named "Fanglan Zha"
Article Synopsis
- Iron is crucial for microbial survival, but too much can impede growth; thus, microbes must regulate iron balance and metabolite production.
- The study reveals that the stringent starvation protein A (SspA) enhances prodiginine production by promoting iron absorption in Pseudoalteromonas sp., and its regulation is intricately linked to ppGpp, a small nucleotide molecule.
- Findings show that ppGpp accumulates under low iron conditions, positively influencing SspA levels and iron uptake, while also having a direct role in modulating both iron absorption and prodiginine biosynthesis, suggesting potential for future manipulation of prodiginine production.
Organisms need sufficient intracellular iron to maintain biological processes. However, cells can be damaged by excessive iron-induced oxidation stress. Therefore, iron homeostasis must be strictly regulated.
View Article and Find Full Text PDFProdiginines are a family of red-pigmented secondary metabolites with multiple biological activities. The biosynthesis of prodiginines is affected by various physiological and environmental factors. Thus, prodiginine biosynthesis regulation is highly complex and multifaceted.
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