Alkaloids with Their Protective Effects Against A-Induced PC-12 Cell Injury from the Tubers of Schott.

Seven new alkaloids [, (±)-, (±)-, , and ] and one new natural product (), along with eight known analogues, were isolated from the tubers of Schott. Their structures were determined by a comprehensive analysis of spectroscopic data, including HRESIMS, and electronic circular dichroism (ECD). In addition, the results of the bioactivity evaluation showed that compounds (±)-, , and exhibited significantly protective effects against A-induced PC-12 cell injury and ameliorated cell viabilities by decreasing the levels of the reactive oxidative species (ROS) and mitochondrial membrane potential (MMP).