Publications by authors named "Fangfei Hu"
Introduction: Kinesio taping (KT) has been extensively applied in the management of musculoskeletal disorders (MSDs). Although plentiful systematic reviews (SRs) have evaluated its efficacy, there are no convincing conclusions due to dispersed and inconclusive results, and its clinical relevance remains unclear. Hence, there is a need to summarise all the SRs for comprehensive and consistent evidence.
View Article and Find Full Text PDFObjective: Our study is to identify DEGs (Differentially Expressed Genes), comprehensively investigate hub genes, annotate enrichment functions and key pathways of Non-functional pituitary adenomas (NFPAs), and also to verify STO-609 therapeutic effect.
Methods: The gene expression level of NFPA and normal tissues were compared to identify the DEGs (Differential expressed genes) based on gene expression profiles (GSE2175, GSE26966 and GSE51618). Enrichment functions, pathways and key genes were identified by carrying out GO (Gene Ontology), KEGG (Kyoto Encyclopedia of Genes and Genomes) analysis and PPI (Protein-Protein Interation) network analysis.
Article Synopsis
- - The study investigated the effects of three drugs (T5224, RSPO2, and AZD5363) on functioning pituitary adenoma (FPA) by analyzing gene expression profiles from multiple datasets to identify differentially expressed genes.
- - Through laboratory experiments, the drugs were shown to significantly reduce cell viability and clonogenicity in FPA cells, with an increase in apoptosis as drug dosage increased.
- - Key genes (cFos, WNT5A, NCAM1, JUP, AKT3, and ADCY1) were found to be abnormally expressed in FPA cells, indicating their potential as targets for future therapeutic strategies.