[Comparative study on metabonomics and on liver and kidney toxicity of Aristolochia fangchi and Stephania tetrandra].

Objective: Combined the blood biochemical markers, the renal histopathological changes and the metabonomics profile were investigated to study the toxicity differences between Aristolochia fangchi and Stephania tetrandra.

Method: Ten rats were randomly selected from 70 male Wistar rats as blank control group. The remaining 60 rats were divided into three groups.

[Nephrotoxicity study of Aristolochia fangchi in rats by metabonomics].

Objective: To study the changes of metabolites in rat urine after treatment of Aristolochia fangchi decoction by metabonomic method.

Methods: Sixty-four male SD rats were divided into Aristolochia fangchi group and normal control group. Rats in the Aristolochia fangchi group were orally administered with 8.