Publications by authors named "FangYuan Long"
Gasdermin E (GSDME) has recently been identified as a critical executioner to mediate pyroptosis. While epidermal keratinocytes can initiate GSDME-mediated pyroptosis, the role of keratinocyte GSDME in psoriatic dermatitis remains poorly characterized. Through analysis of GEO datasets, we found elevated GSDME levels in psoriatic lesional skin.
View Article and Find Full Text PDFEffect of SARS-CoV-2 infection and vaccine on ovarian reserve: A systematic review.
Eur J Obstet Gynecol Reprod Biol
January 2024
Objective: To evaluate the effect of SARS-CoV-2 infection and vaccination on ovarian reserve.
Methods: Relevant articles were identified in the EMBASE, PubMed, and Web of Science databases from January 2020 to May 2023. Available clinical indicators of ovarian reserve, such as anti-Müllerian hormone (AMH), antral follicle count (AFC), follicle-stimulating hormone (FSH), and estradiol (E2), as well as the time interval from infection or vaccination to measurements, were assessed.
In late 2019, SARS-CoV-2 was detected in China and spread worldwide. In rare cases, children who were infected with COVID-19 may develop multisystem inflammatory syndrome (MIS-C), which could have higher mortality than COVID-19 itself. Therefore, diagnosis and management are critical for treatment.
View Article and Find Full Text PDFArticle Synopsis
- Psoriasis is a disease that can lead to problems during pregnancy, and scientists found that it may also affect the quality of eggs (oocytes) produced in females.
- In a study using mice that had psoriasis-like symptoms, researchers discovered that the eggs had issues like disorganized chromosomes and were not developing properly.
- They also found that adding melatonin helped improve the quality of the eggs by reducing stress on the cells and fixing some of the problems caused by psoriasis.
Dermoscopy is an efficient and non-invasive technique which has been widely used in the diagnosis of nail disorders including nail psoriasis (NP). Many nail dermoscopic features are considered as clues to NP. The aim of this study was to investigate specific dermoscopic features of fingernail psoriasis and the correlation between the severity of nail lesions or systemic inflammation, and psoriasis severity of skin and nail.
View Article and Find Full Text PDFIntramatricial low-dose secukinumab injection for nail psoriasis.
Indian J Dermatol Venereol Leprol
November 2021
Acitretin inhibits IL-17A-induced IL-36 expression in keratinocytes by down-regulating IκBζ.
Int Immunopharmacol
February 2020
Background: IL-36 plays a critical role in aggravating psoriatic inflammation, which is significantly elevated in generalized pustular psoriasis (GPP) compared to psoriasis vulgaris. It is well known that acitretin brings about a rapid and significant effect on the treatment of GPP but not psoriasis vulgaris, whereas the quick therapeutic mechanism of acitretin in GPP has not been fully clarified.
Objectives: We conducted this study to investigate whether acitretin interferes IL-36 expression in keratinocytes.