Plaque erosion risk and JAK2 V617F variant.

Background And Aims: Clonal haematopoiesis of indeterminate potential (CHIP) can increase the risk of myocardial infarction (MI). Among various CHIP mutations, JAK2 V617F substantially elevated this risk. However, the specific associations between JAK2 V617F and two mechanisms of MI, plaque erosion and plaque rupture, remain unclear.

Joint Spatial and Frequency Domain Learning for Lightweight Spectral Image Demosaicing.

Conventional spectral image demosaicing algorithms rely on pixels' spatial or spectral correlations for reconstruction. Due to the missing data in the multispectral filter array (MSFA), the estimation of spatial or spectral correlations is inaccurate, leading to poor reconstruction results, and these algorithms are time-consuming. Deep learning-based spectral image demosaicing methods directly learn the nonlinear mapping relationship between 2D spectral mosaic images and 3D multispectral images.

A visual cortical-lateral posterior thalamic nucleus circuit regulates depressive-like behaviors in male mice.

Depression, a prevalent psychiatric disorder of ambiguous etiology and high heterogeneity, has been recently linked to the primary visual cortex (V1). However, the precise circuits mediating the impact of V1 on depressive-like behaviors are poorly understood. Here, we demonstrate that the V1, specifically the lateral posterior nucleus of the thalamus (LP)-projecting V1 glutamatergic subpopulation (Glu neurons), shows reduced activity after chronic restraint stress (CRS) in male mice, leading to depressive-like behaviors.

Deubiquitinase USP9X controls Wnt signaling for CNS vascular formation and barrier maintenance.

Deubiquitinating enzymes play crucial roles in various cellular activities, yet their involvement in central nervous system (CNS) vascularization and barrier function remains elusive. Canonical Wnt signaling is essential for proper CNS vascularization and barrier maintenance. Using a loss-of-function screening for Wnt-signaling activity, we identified ubiquitin-specific peptidase 9 X-linked (USP9X) as a key regulator in brain endothelial cells (BECs).

Perspectives of nurses and patients on the misplacement of supportive care information for type 2 diabetes mellitus: a qualitative study in China.

Objective: This study aimed to investigate the perspectives of nurses and patients on the misplacement of supportive care information for type 2 diabetes mellitus (T2DM).

Methods: A descriptive qualitative study was conducted using purposive sampling to recruit elderly individuals diagnosed with T2DM and nurses from a geriatric hospital in the central region of China. Semi-structured interviews were carried out between June and October 2024.

miR-211 Regulates Cutaneous Wound Healing through Inhibiting Inflammatory Reactions and Oxidative Stress by Binding SOX11.

Introduction: Loss of skin integrity due to a wound or disease can lead to severe disability or even life threat. The highly expressed microRNAs in the skin are of great significance for skin development. The purpose of the investigation was to explore the effect and mechanism of miR-211 on inflammation, oxidative stress, and migration in keratinocytes.

A Study on the Effect of Nickel-Plated Graphite Content on the Microstructure and Properties of AlZn/Nickel-Plated Graphite Composite Cold Spray Coatings.

Aluminum and its alloys are widely used in the busbar structures of electrolytic aluminum production. However, they are prone to corrosion and wear damage during use, leading to a decline in current-transmission efficiency and potentially causing safety issues. To repair damaged aluminum busbars, this paper explores the feasibility of using cold spraying technology for surface restoration.

LncRNA A1BG-AS1 regulates the progress of diabetic foot ulcers via sponging miR-214-3p.

Nerve aberrations and vascular lesions in the distal lower limbs are the etiological factors for diabetic foot ulcers (DFUs). This study aimed to understand the regulatory mechanism of angiogenesis in patients with DFU by examining lncRNA, as well as to explore effective targets for diagnosing and treating DFU. The serum levels of A1BG-AS1 and miR-214-3p and the predictive power of A1BG-AS1 for DFU were determined by quantitative PCR and ROC analysis.

Biocontrol mechanisms of antagonistic yeasts on postharvest fruits and vegetables and the approaches to enhance the biocontrol potential of antagonistic yeasts.

During storage and transportation, fruits and vegetables are susceptible to various pathogens, leading to quality degradation and significant economic losses. Currently, chemical pesticides are primarily used for control; however, their overuse poses serious threats to human health and causes environmental pollution. Biocontrol, known for its environmentally friendly characteristics, has been extensively studied.

Analysis of genetic instability induced by radon exposure in iron mine processing workers in Shandong Province, Northern China.

Background: Radon, a colorless and odorless radioactive gas, poses serious health risks. It is the second leading cause of lung cancer and notably increases lung cancer risk in smokers. Although previous epidemiological studies have mainly examined lung cancer rates in miners, the effects of radon on genomic stability and its molecular mechanisms are not well understood.

Relationship between gestational body mass index, blood pressure variability, and postpartum depression in pregnant women with pre-eclampsia.

Background: Pre-eclampsia has long been proven to be an independent risk factor for postpartum depression (PPD). Excessive increase in body mass index (BMI) during pregnancy is an important factor inducing pre-eclampsia. Increased blood pressure is the main symptom of patients with pre-eclampsia.

Directing Zn Growth with Biased Adsorption of Straight-chain Molecules for Superior Zn Anode Stability.

Aqueous zinc ion batteries (AZIBs), which have attracted attentions in the field of energy storage, is affected by dendrites and side reactions of Zn anode, resulting in an unsatisfactory performance of AZIBs. Herein, we propose a biased adsorption strategy mediated by straight-chain molecule (Scm) for stabilizing Zn anode. The dual polar termini of Scms guaranties securely anchor themselves in a parallel orientation upon the Zn anode surface.

Selenium-mediated alleviation of skeletal muscle atrophy through enterotype modulation in mice.

Skeletal muscle is crucial for health, and glucocorticoid-induced atrophy poses a significant clinical challenge. This study utilized a dexamethasone (Dex)-induced mouse model to assess the impact of selenium supplementation on skeletal muscle atrophy during and after Dex treatment. Increasing evidence suggests the existence of a 'gut-muscle axis', where gut microbiota plays a regulatory role in muscle metabolism and function.

Clinical Effects of Thread-Dragging Therapy on Gangrene of Non-ischemic Diabetic Foot Ulcers.

Objective: To investigate the clinical effects of thread-dragging therapy on gangrene of non-ischemic diabetic foot ulcers (NIDFU).

Methods: A total of 136 patients with NIDFU were recruited from the Department of Peripheral Vascular Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine between June 21, 2021 and February 1, 2023, and randomized into an intervention group and a control group, with 68 cases in each group. Both groups received basic treatment.

Kindlin-2 Phase Separation in Response to Flow Controls Vascular Stability.

Background: Atheroprotective shear stress preserves endothelial barrier function, while atheroprone shear stress enhances endothelial permeability. Yet, the underlying mechanisms through which distinct flow patterns regulate EC integrity remain to be clarified. This study aimed to investigate the involvement of Kindlin-2, a key component of focal adhesion and endothelial adherens junctions crucial for regulating endothelial cell (EC) integrity and vascular stability.

Multi-Scale Spatio-Temporal Memory Network for Lightweight Video Denoising.

Deep learning-based video denoising methods have achieved great performance improvements in recent years. However, the expensive computational cost arising from sophisticated network design has severely limited their applications in real-world scenarios. To address this practical weakness, we propose a multiscale spatio-temporal memory network for fast video denoising, named MSTMN, aiming at striking an improved trade-off between cost and performance.

Design and tuning of S-band traveling wave accelerating structures for Hefei Advanced Light Facility.

The Hefei Advanced Light Facility (HALF) injector comprises 40 S-band 3-m traveling wave accelerating structures, capable of delivering electrons with a full energy of 2.2 GeV into the storage ring. To mitigate emittance degradation caused by field asymmetry in the coupler cavity, the coupler design incorporates a racetrack and a short-circuit waveguide.

Heterogeneity of SARS-CoV-2 immune responses after the nationwide Omicron wave in China.

It remains unclear how previous infections and vaccinations influenced and shaped heterogeneous immune responses against Omicron and its variants in diverse populations in China. After the national wave of Omicron in early 2023, we evaluated serum levels of neutralizing antibodies (nAbs) against Omicron (B.1.

A Strongly Coupled Metal/Hydroxide Heterostructure Cascades Carbon Dioxide and Nitrate Reduction Reactions toward Efficient Urea Electrosynthesis.

The direct coupling of nitrate ions and carbon dioxide for urea synthesis presents an appealing alternative to the Bosch-Meiser process in industry. The simultaneous activation of carbon dioxide and nitrate, however, as well as efficient C-N coupling on single active site, poses significant challenges. Here, we propose a novel metal/hydroxide heterostructure strategy based on synthesizing an Ag-CuNi(OH) composite to cascade carbon dioxide and nitrate reduction reactions for urea electrosynthesis.

Extracorporeal shock wave therapy (ESWT) favors healing of diabetic foot ulcers: A systematic review and meta-analysis.

Aims: To investigate the efficacy and safety of extracorporeal shockwave therapy(ESWT) for diabetic foot ulcers(DFUs).

Methods: Search in PubMed, EMBASE, the Cochrane Controlled Register of Trials (CENTAL), and Web of Science for randomized controlled trials (RCTs) published before August 8, 2023. All identified studies were screened following the selection criteria.

An economical preparation strategy of magnetic biochar with high specific surface area for efficient removal of methyl orange.

Magnetic biochar (MBC) was obtained from pepper straw by impregnation-microwave pyrolysis method. The pyrolysis temperature and FeCl impregnation concentration were investigated on the structural properties of MBC and the adsorption of methyl orange (MO) in water. Characterization results showed that pyrolysis temperature and iron species significantly increased the specific surface area of MBC, which could reach the maximum of 2038.

A transcriptional cascade involving BBX22 and HY5 finely regulates both plant height and fruit pigmentation in citrus.

Dwarfing is a pivotal agronomic trait affecting both yield and quality. Citrus species exhibit substantial variation in plant height, among which internode length is a core element. However, the molecular mechanism governing internode elongation remains unclear.