HER3-targeting Antibody-drug Conjugates Therapy for Solid Tumors: Recent Advances and Future Potentials.

In most advanced cancers, standard medical treatments are generally employed. With the emergence of Antibody-Drug Conjugates (ADCs), more optimal therapeutic methods have become available for treating tumors. ADC is composed of a monoclonal antibody that targets a specific antigen and a cytotoxic payload, which conjugates via the synthetic linkers.

Noninvasive preimplantation genetic testing for aneuploidy using blastocyst spent culture medium may serve as a backup of trophectoderm biopsy in conventional preimplantation genetic testing.

Background: To investigate whether the noninvasive preimplantation genetic testing (niPGT) complement conventional preimplantation genetic testing (PGT) in the embryos for aneuploidy.

Results: 40 spent culture medium (SCM) samples from routine embryo culture were collected, and half of each SCM (10 µL) sample was used for whole genome amplification, while the other half was stored at -80 °C for 3-6 months. Thirty-six out of 40 fresh SCM samples were successfully amplified and sequenced.

The role of in maintaining health: a bibliometric study.

Background: , as a probiotic, is negatively linked to IBD, obesity, and T2DM. The aim of this study was to comprehensively assess the research status of over the past decade and explore the relationships between this bacterium and various health-related aspects.

Methods: Tools VOSviewer, Bibliometrix, and CiteSpace were used to analyze various aspects including publication metrics, contributors, institutions, geography, journals, funding, and keywords.

Endoscopic surgery affects the gut microbiota and its metabolism in breast cancer patients.

Background: Despite the advantages of endoscopic surgery in reducing trauma and enhancing recovery for breast cancer patients, its impact on gut microbiota, which is crucial for health and estrogen metabolism, remains unclear. Further investigation is necessary to fully understand this impact and its implications.

Materials And Methods: Between June and December 2022, fecal samples were collected from 20 patients who underwent endoscopic surgery.

Integrated Metabolomic and Transcriptomic Analysis Reveal the Production Mechanism of Semicarbazide in Under Urea Conditions.

Semicarbazide (SEM) is commonly utilized as a biomarker for detecting the usage of nitrofurazone (NFZ); however, its endogenous presence in aquatic products complicates detection and poses challenges to the quality and safety of these products. Although previous research suggests a potential link between SEM and urea, the specific mechanisms underlying its production under induced conditions remain unclear. To solve the above problem, the integrated metabolomic and transcriptomic analyses were performed for systematically exploring endogenous production mechanisms underlying SEM in under urea conditions.

Short sleep time has a greater impact on the gut microbiota of female.

Background/objective: Short sleep duration (SSD) affects people's health in multiple ways. This study attempted to explore the effect of SSD on the gut microbiota.

Methods: In the American Gut Project Database, 361 individuals (without troubled by disease recently) with less than 6 h of sleep per day were obtained and matched with normal sleep time individuals according to gender, age, and BMI.

Guest modulating the photoactivity of a titanium-oxide cage.

Two host-guest Ti-oxide clusters, Ti(NH) and TiCs, were synthesized and thoroughly characterized. They possess a rarely seen biloculate structure that encapsulates two NH and Cs guests, respectively. Interestingly, alkali metal cations can exchange places with NH .

Dl-3-n-Butylphthalide attenuates early brain injury and delayed neurological dysfunction by regulating NLRP3 inflammasome after subarachnoid hemorrhage.

Subarachnoid hemorrhage (SAH) is a severe neurological event lacking of effective therapy. Early brain injury (EBI) and delayed neurological dysfunction are important cause in the poor prognosis of patients with SAH. Nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain containing 3 (NLRP3) inflammasome activation has been implicated in many inflammatory lesion pathogeneses including SAH.

Case report: response to immunotherapy and association with the fh gene in hereditary leiomyomatosis and renal cell cancer-associated renal cell cancer.

Hereditary leiomyomatosis and renal cell cancer (HLRCC) is a rare autosomal dominant syndrome caused by a germline mutation in the fumarate hydratase (FH) gene that manifests with cutaneous leiomyomas, uterine fibroids, and renal cell cancer (RCC). Patients with HLRCC-associated RCC (HLRCC-RCC) have aggressive clinical courses, but there is no standardized therapy for advanced HLRCC-RCC. In this study, we described a case of aggressive HLRCC in a 33-year-old female who exhibited a novel heterozygous germline insertion mutation in exon 8 of the FH gene (c.

A Novel Endoscopic Approach for Treating Breast Cancer: Haigui-1 Hole.

Objective: Endoscopic surgery is an effective technique for preserving the nipple and areola, as well as for sentinel lymph node biopsy and breast implant reconstruction. However, the technical challenges associated with endoscopic surgery have limited its widespread adoption.

Methods: In the normal single-port endoscopic surgery, the ultrasonic knife was accessed through the retractor.

Enhancing the photocatalytic performance of a rutile unit featuring a titanium-oxide cluster by Pb doping.

Titanium-oxide clusters (TOCs) are well-defined molecular models for TiO materials and provide the opportunity to study the structure-activity relationships of TiO. Here, we report a new Pb-doped TOC, Ti12Pb2, which resembles a two-layer decker of the {TiTi} structural units of rutile TiO with two Ti ions replaced by two Pb ions. Its electronic structure, photoresponse, and photocatalytic performances were investigated and compared with those of the Ti14 cluster, which is isostructural to Ti12Pb2.

Development of preimplantation genetic testing for monogenic reference materials using next-generation sequencing.

Objective: Preimplantation genetic testing for monogenic disorders (PGT-M) has been used for over 20 years to detect many serious genetic conditions. However, there is still a lack of reference materials (RMs) to validate the test performance during the development and quality control of PGT-M.

Method: Sixteen thalassemia cell lines from four thalassemia families were selected to establish the RMs.

Palladium-Catalyzed C(sp)-H Nitrooxylation of Aliphatic Carboxamides with Practical Oxidants.

Here we report the palladium-catalyzed β-C(sp)H nitrooxylation of aliphatic carboxamides using a modified quinoline auxiliary. Notably, Al(NO)·9HO was used as a nitrate source as well as a practical oxidant. The 5-chloro-8-aminoquinoline auxiliary was nitrated in situ during the reaction, which may enhance its directing ability and help its removal.

A cryptand-like Ti-coordination compound with visible-light photocatalytic activity in CO storage.

A cryptand-like Ti-coordination compound, namely Ti12Cs, comprising two Ti-salicylate cages and hosting two Cs ions, was synthesized by the solvothermal method. It exhibits strong visible-light absorption with an absorption band edge of 652 nm, attributed to the electron transition from salicylate ligands to Ti ions. Electrochemical impedance, visible-light transient photocurrent response, and photoluminescence spectra confirm that Ti12Cs has excellent visible-light response and charge-separation properties.

Photo-self-Fenton Reaction Mediated by Atomically Dispersed Ag-Co Photocatalysts toward Efficient Degradation of Organic Pollutants.

Achieving the complete mineralization of persistent pollutants in wastewater is still a big challenge. Here, we propose an efficient photo-self-Fenton reaction for the degradation of different pollutants using the high-density (Ag: 22 wt %) of atomically dispersed AgCo dual sites embedded in graphic carbon nitride (AgCo-CN). Comprehensive experimental measurements and density functional theory (DFT) calculations demonstrate that the Ag and Co dual sites in AgCo-CN play a critical role in accelerating the photoinduced charge separation and forming the self-Fenton redox centers, respectively.

Clinical efficacy of Camrelizumab combined with first-line chemotherapy in extensive-stage small-cell lung cancer.

Objective: Exploring the clinical efficacy of camrelizumab in combination with first-line chemotherapy in patients with extensive-stage small-cell lung cancer (ES-SCLC).

Methods: The clinical data of 35 patients with ES-SCLC who received camrelizumab combined with EC or EP regimen in First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from January 2020 to January 2023 were retrospectively analyzed. The primary endpoint was progression-free survival (PFS), and the secondary endpoints were OS, ORR and DCR.

Ligation of Titanium-oxide and {Mo} Units for Solar CO Storage.

Two Mo-Ti-mixed oxide clusters, and , which contain the {Mo} unit commonly observed in many polyoxomolybdates, were successfully synthesized. The introduction of a {Mo} dopant into a titanium-oxide cluster (TOC) results in a red shift of the absorption edge, hence leading to a substantial enhancement of visible-light absorption. The band gap electron transition mainly involves the ligand-to-metal charge transfer (LMCT, benzoate-to-Mo) and Mo d-d transition.

Apatinib plus chemotherapy for non-metastatic osteosarcoma: a retrospective cohort study.

Background: Effective adjuvant therapy for osteosarcoma is necessary for improved outcomes. Previous studies demonstrated that apatinib plus doxorubicin-based chemotherapy may improve the efficacy of neoadjuvant therapy. This study aimed to clarify the effectiveness and safety of apatinib plus doxorubicin and cisplatin (AP) as neoadjuvant therapy for osteosarcoma.

Divalent Heterometal Doped Titanium-Oxide Cluster Polymers: Structures, Photoresponse, and Photocatalysis.

Five cluster polymers based on heterometal-doped titanium-oxide cluster (TOC) monomers are reported. The monomers feature Ti-oxide cluster cores and are connected to the divalent closed-shell heterometal anchors by salicylate ligands. The Sr, Ba, and Pb dopants cause the monomers to bind head-to-head and generate linear chains, while the Ca and Cd lead to head-to-tail connections and zigzag chains.

The clinical application of atorvastatin in patients with small-cell lung cancer with dyslipidemia.

Background: Various experimental studies demonstrated that atorvastatin exerted additive effects with anticancer drugs to impair tumor growth, delay relapse, and prolong survival time in lung cancer. However, it is indistinct whether there are survival benefits of atorvastatin in the treatment of small-cell lung cancer (SCLC) patients with dyslipidemia. Therefore, this study aimed to evaluate the efficacy and safety of atorvastatin plus first-line standard chemotherapy in SCLC combined dyslipidemia.

Morphotropic Phase Boundary in Polarized Organic Piezoelectric Materials.

Designing the morphotropic phase boundary (MPB) has been the most sought-after approach to achieve high piezoelectric performance of piezoelectric materials. However, MPB has not yet been found in the polarized organic piezoelectric materials. Here, we discover MPB with biphasic competition of β and 3/1-helical phases in the polarized piezoelectric polymer alloys (PVTC-PVT) and demonstrate a mechanism to induce MPB using the compositionally tailored intermolecular interaction.

Boosting Charge Utilization in Self-Powered Photodetector for Real-Time High-Throughput Ultraviolet Communication.

Ultraviolet (UV) communication is a cutting-edge technology in communication battlefields, and self-powered photodetectors as their optical receivers hold great potential. However, suboptimal charge utilization has largely limited the further performance enhancement of self-powered photodetectors for high-throughput communication application. Herein, a self-powered Ti C T -hybrid poly(3,4 ethylenedioxythiophene):poly-styrene sulfonate (PEDOT:PSS)/ZnO (TPZ) photodetector is designed, which aims to boost charge utilization for desirable applications.

Case report: Apatinib combined with neoadjuvant therapy for primary squamous cell carcinoma of the breast: a case report.

Primary squamous cell carcinoma of the breast is a rare subtype of carcinoma of chemosis for which there is no effective chemotherapy regimen. Breast squamous cell carcinoma is usually "triple negative", with poor chemotherapy effects and poor prognosis. Here, we report a successful case of primary breast squamous cell carcinoma treated with apatinib.

Bioinformatics identification and validation of aging‑related molecular subtype and prognostic signature in breast cancer.

Patients with metastatic breast cancer have a poor clinical outcome, accounting for more than 90 percent of breast cancer-related deaths. Aging could regulate many biological processes in malignancies by regulating cell senescence. The role of aging has not been fully clarified.