Publications by authors named "Fang-yang Huang"
Article Synopsis
- Epidemiological studies indicate a link between psoriasis and aortic valve stenosis (AS), but the nature of this relationship is not fully understood, prompting a study using Mendelian randomization (MR) analysis to investigate.
- A two-sample MR analysis was performed with data from genome-wide association studies (GWAS), identifying genetic factors and gene networks that may connect psoriasis to AS, resulting in 15 key hub genes being recognized.
- The findings suggest a significant causal relationship, with individuals genetically predisposed to psoriasis having a higher risk of AS, and highlight the role of immune-related pathways and gene expression in the progression of both conditions.
Background: The impact of cardiac arrest (CA) at admission on the prognosis of patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS) remains a subject of debate.
Methods: We conducted a retrospective study at West China Hospital from 2018 to 2021, enrolling 247 patients with AMI complicated by CS (AMI-CS). Patients were categorized into CA and non-CA groups based on their admission status.
Background: We aimed to investigate whether the pressure injury risk mediates the association of left ventricular ejection fraction (LVEF) with all-cause death in patients with acute myocardial infarction (AMI) aged 80 years or older.
Methods: This retrospective cohort study included 677 patients with AMI aged 80 years or older from a tertiary-level hospital. Pressure injury risk was assessed using the Braden scale at admission, and three risk groups (low/minimal, intermediate, high) were defined according to the overall score of six different variables.
Article Synopsis
- Left ventricular hypertrophy (LVH) is common in obese individuals, and both conditions are linked to subclinical left ventricle dysfunction; the study examines their combined impact on mortality in coronary artery disease (CAD) patients.* -
- Out of 2243 participants, 25% exhibited higher body fat, and nearly 47% had LVH; their 2.2-year follow-up revealed that those with both higher body fat and LVH had the highest mortality rates (8.2%).* -
- Findings indicate that increased body fat significantly raises the risk of all-cause death only in patients with LVH, highlighting the importance of considering both factors in assessing mortality risk in CAD patients.*
Objective: We sought to conduct a systematic review and meta-analysis of clinical adverse events in patients undergoing transcatheter aortic valve replacement (TAVR) with bicuspid aortic valve (BAV) vs. tricuspid aortic valve (TAV) anatomy and the efficacy of balloon-expandable (BE) vs. self-expanding (SE) valves in the BAV population.
View Article and Find Full Text PDFObjectives: We sought to identify the impact of transcatheter aortic valve implantation (TAVI) on changes of fractional flow reserve computed tomography (FFR) values and the associated clinical impact.
Methods: A retrospective analysis was done with CT obtained pre-TAVI, prior to hospital discharge and at 1-year follow-up, which provided imaging sources for the calculation of FFR values based on an online platform.
Results: A total of 190 patients were enrolled.
Background: Few studies from developed countries have quantitatively characterized the clinical characteristics and outcomes of patients receiving contemporary intensive cardiac care. We sought to investigate these data in patients admitted to a Chinese intensive cardiac care unit (ICCU).
Methods: We conducted a retrospective study using data from 2,337 consecutive admissions to the ICCU at a large centre in China from June 2016 to May 2017.
Background: The relationship between renal function and outcomes among patients with hypertrophic cardiomyopathy (HCM) remains undefined. We sought to investigate the prevalence of renal dysfunction and its prognostic value in HCM patients.
Methods: A total of 581 patients with HCM were consecutively recruited.
Background: Comorbidities are commonly seen in patients with coronavirus disease 2019 (COVID-19), but the clinical implication is not yet well-delineated. We aim to characterize the prevalence and clinical implications of comorbidities in patients with COVID-19.
Methods: This is a retrospective multi-centre study involving patients admitted between January 16th and March 10th 2020.
Article Synopsis
- The study examined the role of gender in the presentation and outcomes of hypertrophic cardiomyopathy (HCM) in 576 Chinese patients, highlighting differences between males and females.
- Female patients were older and had more severe symptoms at diagnosis compared to male patients, along with higher left ventricular outflow tract gradients.
- Although there were no significant differences in overall or cardiovascular mortality rates between genders, females had a higher rate of being rehospitalized due to heart failure.
Objective: We sought to explore the prevalence and immediate clinical implications of acute myocardial injury in a cohort of patients with COVID-19 in a region of China where medical resources are less stressed than in Wuhan (the epicentre of the pandemic).
Methods: We prospectively assessed the medical records, laboratory results, chest CT images and use of medication in a cohort of patients presenting to two designated covid-19 treatment centres in Sichuan, China. Outcomes of interest included death, admission to an intensive care unit (ICU), need for mechanical ventilation, treatment with vasoactive agents and classification of disease severity.
Stromal cell-derived factor-1 (SDF-1) is a well-characterized cytokine that protects heart from ischaemic injury. However, the beneficial effects of native SDF-1, in terms of promoting myocardial repair, are limited by its low concentration in the ischaemic myocardium. Annexin V (AnxA5) can precisely detect dead cells in vivo.
View Article and Find Full Text PDFBackground: Ageing is a risk factor for both coronary artery disease (CAD) and reduced renal function (RRF), and it is also associated with poor prognosis in patients with CAD or RRF. However, little is known about whether the impact of RRF on clinical outcomes are different in CAD patients at different age groups. This study aimed to investigate whether ageing influences the effect of RRF on long-term risk of death in patients with CAD.
View Article and Find Full Text PDFThe triglyceride paradox in the mortality of coronary artery disease.
Lipids Health Dis
January 2019
Background: The role of triglyceride (TG) in secondary prevention of patients with coronary artery disease (CAD) was debated. In the present study, we assessed the association between admission TG levels and long-term mortality risk in CAD patients.
Methods: A retrospective analysis was conducted from a single registered database.
Background: Exercise-based cardiac rehabilitation (CR) has been recognized as an essential component of the treatment for coronary heart disease (CHD). Determining the efficacy of modern alternative treatment methods is the key to developing exercise-based CR programs.
Methods: Studies published through June 6, 2016, were identified using MEDLINE, EMBASE, and the Cochrane Library.
Background: The impact of renal function on the prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) remains unclear in coronary artery disease (CAD). This study sought to investigate the value of using NT-proBNP level to predict prognoses of CAD patients with different estimated glomerular filtration rates (eGFRs).
Methods: A retrospective analysis was conducted from a single registered database.
Background: Elderly patients with coronary artery disease (CAD) frequently complicated with more cardiovascular risk factors, but received fewer evidence-based medications (EBMs). This study explored the association of EBMs compliance in different age groups and the risk of long-term death.
Methods: A retrospective analysis was conducted from a single registered database.
Background: TAVR is a rapidly spreading treatment option for severe aortic valve stenosis. Significant coronary artery disease (CAD) is present in 40% to 75% of patients undergoing TAVR. However, when to treat the concomitant coronary artery lesions is controversial.
View Article and Find Full Text PDFBackground: Statins therapy in the secondary prevention of coronary artery disease (CAD) is associated with a lower risk of adverse cardiovascular events. However, little is known regarding the association of elderly patients with nutritional risk on statin therapy.
Aims: To investigate whether older patients with CAD who were at nutritional risk gain similar survival benefit from statins therapy as their counterparts without nutritional risk.
Frequent premature atrial complexes (PACs) are universal in the general population; however, their clinical significance is unclear. We hypothesize that frequent PACs are associated with increased risk of stroke and death. The PubMed (from 1966 to April 2017) and Embase (from 1974 to April 2017) databases were searched for longitudinal studies that reported the relation of PACs with incidence of stroke and death with various etiologies.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzed statin prescription trends among nearly 52,000 patients with atherosclerotic cardiovascular disease (ASCVD) in China from 2008 to 2014, highlighting a 58.8% overall prescription rate for these medications at discharge.
- It showed a consistent increase in statin prescriptions across various subtypes of ASCVD, including coronary artery disease and cerebrovascular disease, with prescribed rates for cerebrovascular disease and peripheral arterial disease remaining notably lower.
- The findings suggest a need for improved awareness and medical care integration in China to optimize statin utilization and address disparities in prescription rates among different ASCVD subtypes.
Objective: Obesity is a risk factor for both coronary artery disease (CAD) and chronic renal insufficiency (RI); patients with CAD are prone to obesity and RI. In this study, we try to analyze the effect of body composition on death in CAD patients with mild RI.
Design: Retrospective cohort study.
Fibrinogen (Fib) is considered to be a potential risk factor for the prognosis of patients with acute coronary syndrome (ACS), but it is unclear whether Fib level have synergistic effects to enhance the prognostic value of the GRACE score in patients with ACS. A retrospective analysis was conducted from a single registered database. 2253 consecutive patients with ACS confirmed by coronary angiography were enrolled and were grouped into 3 categories by the tertiles of admission plasma Fib levels.
View Article and Find Full Text PDFFew studies to date address the predictive ability of CHADS-VASc and RCHADS in CAD patients. Our aim is to investigate the prognostic performance of CHADS, CHADS-VASc and RCHADS scores in patients with coronary artery disease (CAD). Angiographically obstructive CAD patients were enrolled.
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