Publications by authors named "Fang-bo Cui"
Introduction: Functions of existing automatic module systems for synthesis of radiopharmaceuticals mainly focus on the radiolabeling of small molecules. There are few modules which have achieved full-automatic radiolabeling of non-metallic and metallic nuclides on small molecules, peptides, and antibody drugs. This study aimed to develop and test a full-automatic multifunctional module system for the safe, stable, and efficient production of radiopharmaceuticals.
View Article and Find Full Text PDFArticle Synopsis
- MiR-21 is a key oncogenic microRNA often found at high levels in gastric cancer, which reduces the effectiveness of trastuzumab, a treatment targeting HER2 receptors.
- This study develops nanoparticles coated with trastuzumab to specifically deliver anti-miRNA-21 oligonucleotides (AMO-21) to HER2-overexpressing gastric cancer cells, enhancing their cellular uptake and efficacy.
- The findings suggest that these modified nanoparticles not only improve the delivery and effectiveness of AMO-21 but also increase the sensitivity of gastric cancer cells to trastuzumab, highlighting a promising strategy for targeted cancer therapy.
Article Synopsis
- The study aimed to assess the effectiveness of human recombinant endostatin (Endostar®) in combination with cisplatin doublets for treating advanced non-small cell lung cancer (NSCLC) and to use CT perfusion imaging for evaluating outcomes.
- Conducted from April 2011 to September 2014, 76 NSCLC patients were split into two groups: one received Endostar® before chemotherapy (group A), while the other received it from the start of treatment (group B).
- Results showed a statistically significant difference in treatment effectiveness between the two groups, with group A showing better outcomes; CT perfusion imaging proved useful for assessing the results, while adverse reactions were similar in both groups.
Aberrant methylation of the transcription factor AP-2 epsilon (TFAP2E) has been attributed to 5-fluorouridine (5-FU) sensitivity. 5-Aza-2'-deoxycytidine (DAC), an epigenetic drug that inhibits DNA methylation, is able to cause reactive expression of TFAP2E by demethylating activity. This property might be useful in enhancing the sensitivity of cancer cells to 5-FU.
View Article and Find Full Text PDFRadiotherapy is the main locoregional control modality for many types of unresectable tumors, including gastric cancer. However, many patients fail radiotherapy due to intrinsic radioresistance of cancer cells, which has been found to be strongly associated with cancer stem cell (CSC)-like properties. In this study, we developed a nanoparticle formulation to deliver miR-200c, which is reported to inhibit CSC-like properties, and then evaluated its potential activity as a radiosensitizer.
View Article and Find Full Text PDFDocetaxel (DOC) is widely used as radiosensitizer in various tumors, including gastric cancer (GC), but its therapeutic effect remains to be improved. In this study, using docetaxel-loaded nanoparticles (DOC-NPs) based on gelatinase-stimuli strategy, we compared their radioenhancement efficacy with docetaxel in GC. Compared with DOC, radiosensitization of DOC-NPs was improved significantly (sensitization enhancement ratio increased 1.
View Article and Find Full Text PDF