Publications by authors named "Fang-Qun Liu"
Aim: To investigate whether single-nucleotide polymorphisms (SNPs) in the P450 oxidoreductase (POR) gene were correlated with interindividual variations in cytochrome P450 (CYP) 2B6 activity.
Methods: Thirty-six healthy volunteers who tested CYP2B6 and POR polymorphisms were enrolled in the study. CYP2B6 activity was measured by bupropion hydroxylation with LC/MS/MS.
Article Synopsis
- The study investigates how certain gene variants (PTGS1, PTGFR, MRP4) are linked to the effectiveness of latanoprost in reducing intraocular pressure (IOP) in Chinese patients with primary open-angle glaucoma (POAG).
- It involved assessing IOP changes after treatment and analyzing genetic variations through DNA sequencing and regression analysis.
- Findings revealed that certain genetic polymorphisms are significantly associated with lower IOP response to latanoprost, indicating these SNPs may influence treatment outcomes in POAG patients.