Publications by authors named "Fang-Ping Lin"
Article Synopsis
- Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) exhibit similar symptoms, particularly cardiovascular issues, suggesting possible shared immune response mechanisms, especially through neutrophil activation.
- A comprehensive analysis of neutrophil activity was conducted using data from 103 pediatric patients across various conditions, revealing distinct blood signatures and activated neutrophil types unique to KD and MIS-C.
- Findings indicate that CD177 neutrophils in both KD and MIS-C display hyperactivated functions and similar gene expression patterns, which are linked to systemic damage and can potentially guide treatment options with existing FDA-approved drugs.
Background: Hymenoptera stings can induce dysregulated inflammation and immediate hypersensitivity reactions including anaphylaxis. However, the molecular mechanisms underlying peripheral immune responses during Hymenoptera venom allergy (HVA) remain elusive.
Methods: Here we determined the single-cell transcriptomic profiling from highly heterogeneous peripheral blood cells in patients with HVA through unbiased single-cell RNA sequencing and multiple models of computational analyses.
According to cancer statistics reported in 2020, breast cancer constitutes 30% of new cancer cases diagnosed in American women. Histological markers of breast cancer are expressions of the estrogen receptor (ER), the progesterone receptor (PR), and human epidermal growth factor receptor (HER)-2. Up to 80% of breast cancers are grouped as ER-positive, which implies a crucial role for estrogen in breast cancer development.
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