Publications by authors named "Fang-Liang Zhou"
Article Synopsis
- The study aimed to explore how sanguinarine (SAN) affects nasopharyngeal carcinoma (NPC) using network pharmacology and molecular techniques.
- Researchers identified 95 targets for SAN against NPC, narrowing it down to 8 core targets through analysis, including EGFR and TP53.
- Results showed that SAN effectively inhibited NPC cell growth and triggered apoptosis by altering the expression of specific proteins, linking its effects to significant signaling pathways like PI3K/AKT and MAPK.
Background: Myocarditis is a myocardial injury that can easily cause adolescent death. Traditional research models of animal invasion with viral components, lipopolysaccharide (LPS) or porcine myocardial myosin, among others, have the shortcomings of potential biological safety hazards and high animal mortality.
Objective: To explore the construction of a novel myocarditis model with cyclosporine A and the potential genes and pathways associated with it.
Article Synopsis
- Curcumin, an anticancer agent, has limitations due to its adverse effects and low bioavailability, leading to the development of its derivative, curcumin nicotinate (CN).
- The study found that CN effectively inhibits the growth of various cancer cells, including colon and breast cancer, with specific inhibitory concentrations (IC) reported for each type.
- CN promotes cell death and halts the cell cycle in cancer cells through a p53-mediated mechanism, while showing no harmful effects on normal cells, indicating its potential for selective cancer treatment.
[Inhibition of Yiqi Jiedu formula on proliferation of nasopharyngeal carcinoma cells by MAPK/ERK signaling pathway].
Zhongguo Zhong Yao Za Zhi
March 2018
Article Synopsis
- - The study investigates the impact of Yiqi Jiedu formula (YQ) on the growth of CNE2 cells in nasopharyngeal carcinoma, aiming to provide a foundation for its clinical use.
- - YQ treatment significantly reduces CNE2 cell proliferation in a dose- and time-dependent manner, with a calculated IC₅₀ value of 0.5 g·L⁻¹ after 48 hours.
- - The mechanism involves changes in the cell cycle and down-regulation of key proteins in the MAPK/ERK signaling pathway, indicating how YQ affects cancer cell growth and cycle progression.
Article Synopsis
- Nasopharyngeal carcinoma (NPC) is a common cancer in Southern China, and the study focuses on the upregulation of the protein AKR1B10 in tumors.
- Researchers used methods like Western blot and real-time RT-PCR on various tissue samples to measure AKR1B10 expression levels.
- The results showed that AKR1B10 was significantly higher in malignant NPC tissues, particularly in squamous cell carcinoma, and its expression correlated with tumor differentiation, suggesting it could be a new biomarker for NPC.
Article Synopsis
- Cancer stem cells (CSCs) are key players in tumor growth, resistance to treatments, and cancer relapse, highlighting their importance in cancer research.* -
- Recent research has improved our knowledge of CSCs and led to new treatment approaches, particularly focusing on the signaling pathways that control CSC cell death (apoptosis).* -
- The article discusses various agents that can selectively induce apoptosis in CSCs, including synthetic and natural compounds, antibodies, and oligonucleotides, examining their potential as cancer therapies.*