Publications by authors named "Fang-Lan Yu"
Fluconazole induces rapid high-frequency MTL homozygosis with microbiological polymorphism in Candida albicans.
J Microbiol Immunol Infect
December 2017
Background: Candida albicans, a common fungal pathogen that can cause opportunistic infections, is regarded as an apparently asexual, diploid fungus. A parasexual cycle was previously found between homozygotes with opposite mating type-like loci (MTLa/α). Fluconazole-resistant strains had a higher proportion of MTL homozygotes, whereas MTL homozygous C.
View Article and Find Full Text PDFObjective: Acinetobacter baumannii (AB) bacteremia has increasingly emerged as a nosocomial pathogen in healthcare settings, associated with high patient morbidity and mortality. The objective of this study was to compare clinical features, risk factors, treatment outcome, and antibiotic resistance in patients with pneumonia- and non-pneumonia-related AB bacteremia.
Methods: We conducted a retrospective study in a tertiary teaching hospital in northern Taiwan.
Background/purpose: The emergence of resistance to anti-tuberculosis (TB) drugs has become an obstacle to effective TB control. Thus, there is an urgent need to identify patients and initiate adequate treatment for drug-resistant cases in a timely manner. The BACTEC MGIT 960 system is well known for its rapid culturing time, and is in widespread use in Taiwan.
View Article and Find Full Text PDFClinical and epidemiological features of Chryseobacterium indologenes infections: analysis of 215 cases.
J Microbiol Immunol Infect
December 2013
Purpose: This study investigates the clinical and epidemiological features of Chryseobacterium indologenes infections and antimicrobial susceptibilities of C indologenes.
Methods: With 215 C indologenes isolates between January 1, 2004 and September 30, 2011, at a medical center, we analyzed the relationship between the prevalence of C indologenes infections and total prescription of colistin and tigecycline, clinical manifestation, antibiotic susceptibility, and outcomes.
Results: Colistin and tigecycline were introduced into clinical use at this medical center since August 2006.
Article Synopsis
- The study aimed to compare the nephrotoxicity of vancomycin and teicoplanin, two antibiotics used for treating MRSA, using the RIFLE criteria for acute kidney injury (AKI).
- A total of 190 patients were analyzed, with a higher rate of AKI observed in those treated with vancomycin (15 patients) compared to teicoplanin (27 patients), indicating vancomycin may be more likely to cause nephrotoxicity.
- Despite the difference in nephrotoxicity, the study found no significant variations in overall mortality, hospital stay lengths, or costs between the two treatment groups.
Article Synopsis
- A new culture confirmation test called the TBc ID test detects Mycobacterium tuberculosis complex strains through a lateral-flow immunochromatographic assay, focusing on the MPB64 antigen.
- In a study involving 222 primary-positive liquid cultures, the TBc ID test performed well, showing a sensitivity of 98.8% and specificity of 100%, while effectively distinguishing between M. tuberculosis and other mycobacteria.
- The TBc ID test offers a faster turnaround time (under 1 hour) compared to real-time PCR, making it a recommended alternative for identifying M. tuberculosis in liquid cultures over traditional biochemical methods.