Bibliometric analysis and mapping knowledge domain of pterygium: 2000-2019.

Aim: To track the knowledge structure, topics in focus, and trends in emerging research in pterygium in the past 20y.

Methods: Base on the Web of Science Core Collection (WoSCC), studies related to pterygium in the past 20y from 2000-2019 have been included. With the help of VOSviewer software, a knowledge map was constructed and the distribution of countries, institutions, journals, and authors in the field of pterygium noted.

Anterior segment dysgenesis correlation with epithelial-mesenchymal transition in Smad4 knockout mice.

Aim: To explore the molecular mechanisms in lens development and the pathogenesis of Peters anomaly in Smad4 defective mice.

Methods: Le-Cre transgenic mouse line was employed to inactivate Smad4 in the surface ectoderm selectively. Pathological techniques were used to reveal the morphological changes of the anterior segment in Smad4 defective eye.

Study on the optical property and biocompatibility of a tissue engineering cornea.

Aim: To study the optical property and biocompatibility of a tissue engineering cornea.

Methods: : The cross-linker of N-(3-Dimethylaminoropyl)-N'ethylcarbodiimide hydrochloride (EDC)/N-Hydroxysuccinimide (NHS) was mixed with Type I collagen at 10% (weight/volume). The final solution was molded to the shape of a corneal contact lens.