Publications by authors named "Fang-Jung Hsu"
Five new eunicellin-based diterpenoids, klymollins T-X (1-5), along with two known compounds (6 and 7) have been isolated from the soft coral Klyxum molle. The structures of these new metabolites were elucidated by extensive spectroscopic analysis and by comparison with related known compounds. Compound 5 was found to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.
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- Eight new diterpenoids named klymollins A-H were discovered from the soft coral Klyxum molle found in Taiwan.
- Their chemical structures were determined using detailed spectroscopic techniques, with the configuration of one specific compound established through Mosher's method.
- Bioassays indicated that most of these new compounds (3-8) have significant anti-inflammatory effects, particularly by inhibiting iNOS and reducing COX-2 protein levels in stimulated macrophage cells.