Publications by authors named "Fang-Hua Liu"
Background: Ovarian cancer (OC) is a heterogeneous malignancy with multiple histological subtypes, showing global variability in incidence. Temporal changes in diagnostic criteria and risk factors might influence the incidence and distribution of OC and its subtypes.
Methods: This study analyzed incidence patterns (2013-2017) and trends (1988-1992 to 2013-2017) of OC and its subtypes across 65 and 40 countries, respectively.
The present study aims to summarize the current biomarker landscape in gynecological cancers (GCs) and incorporate bioinformatics analysis to highlight specific biological processes. The literature was retrieved from PubMed, Web of Science, Embase, Scopus, Ovid Medline, and Cochrane Library. The final search was conducted on December 7, 2022.
View Article and Find Full Text PDFBackground: Numerous prospective cohort studies have investigated the influence of dietary patterns on the risks of various cancers, although the findings differed.
Objectives: To evaluate the associations of dietary patterns with risks of various cancers and assess the strength and validity of the evidence.
Methods: Relevant articles were retrieved from the PubMed, EMBASE, Web of Science, and Cochrane library databases from inception to February 22, 2024.
Purpose: Although (poly)phenols have shown potential in anti-cancer activities, their impact on improving ovarian cancer (OC) survival remains unknown. Therefore, we aim to first investigate the association between dietary polyphenol intake and OC survival, providing valuable insights into potential interventions.
Methods: The prospective cohort recruited 560 patients with OC to assess the associations of polyphenol intake, not only pre- and post-diagnosis but also the change from pre- to post-diagnosis with OC survival.
Article Synopsis
- Environmental pollution, specifically heavy metals, may negatively impact the prognosis of advanced high-grade serous ovarian cancer (HGSOC), but current evidence is limited.
- A study involving 159 deceased HGSOC patients and 159 matched living patients analyzed urinary levels of five heavy metals—arsenic, cadmium, chromium, mercury, and lead—using statistical models to determine associations with overall survival (OS).
- The results showed significant links between high levels of arsenic, cadmium, mercury, and lead in urine and poorer OS, with lead being the most influential in negatively affecting survival, indicating a need for further research.
Article Synopsis
- - The study investigates the link between adverse pregnancy outcomes and cancer risk in mothers and their children, highlighting a growing concern about these health issues.
- - A systematic review of various databases identified 129 meta-analyses, finding significant associations between factors like birth weight and cancers such as breast and leukemia, with moderate certainty in the evidence.
- - The authors conclude that while there are promising connections between certain adverse pregnancy outcomes and cancer risks, further research is necessary to strengthen these associations and address potential biases.
Article Synopsis
- Meta-analyses have shown mixed results regarding the relationship between whole blood cell count-derived indexes (NLR, PLR, LMR) and cancer prognosis, highlighting the need for a clearer understanding of the evidence quality.* ! -
- The review analyzed 694 associations from 224 articles, revealing that 97.8% of these studies were rated as moderate to high quality based on AMSTAR criteria.* ! -
- Although there were four associations with strong evidence, many others were only suggestive, indicating a need for further research to clarify these relationships and determine causality.* !
Background: Ambient air pollution might serve as a prognostic factor for ovarian cancer (OC) survival, yet the relationships between plant-based diet indices (PDIs) and OC survival remain unclear. We aimed to investigate the associations of comprehensive air pollution and PDIs with OC survival and explored the effects of air pollution-diet interactions.
Methods: The present study encompassed 658 patients diagnosed with OC.
Article Synopsis
- - The study investigated the links between diet quality, as measured by the Healthy Eating Index-2020 (HEI-2020), and survival rates in ovarian cancer patients over a follow-up period until February 2023.
- - It involved 1082 ovarian cancer patients aged 18-79, assessing their dietary habits before and after their diagnosis using a validated food questionnaire.
- - Results indicated that higher diet quality scores led to better overall survival rates, while a decline in diet quality after diagnosis was linked to worse survival outcomes.
Background: Numerous meta-analyses have explored the association between the triglyceride-glucose (TyG) index and diverse health outcomes, yet the comprehensive assessment of the scope, validity, and quality of this evidence remains incomplete. Our aim was to systematically review and synthesise existing meta-analyses of TyG index and health outcomes and to assess the quality of the evidence.
Methods: A thorough search of PubMed, EMBASE, and Web of Science databases was conducted from their inception through to 8 April 2024.
Background: Numerous studies have been conducted to investigate the relationship between ABO and Rhesus (Rh) blood groups and various health outcomes. However, a comprehensive evaluation of the robustness of these associations is still lacking.
Methods: We searched PubMed, Web of Science, Embase, Scopus, Cochrane, and several regional databases from their inception until Feb 16, 2024, with the aim of identifying systematic reviews with meta-analyses of observational studies exploring associations between ABO and Rh blood groups and diverse health outcomes.
Article Synopsis
- The text reviews existing research on the connections between human papillomavirus (HPV) and various cancers, beyond the well-known anogenital and oropharyngeal cancers, highlighting inconsistencies in previous findings.
- An umbrella review was conducted, covering 31 systematic reviews and meta-analyses, and assessed the quality and credibility of the evidence using established tools.
- Findings revealed that while most studies had moderate to high quality, only one HPV type (HPV-18) showed convincing evidence for increased breast cancer risk, whereas HPV was found to be a highly suggestive risk factor for several other cancers, including oral and lung cancer.
Article Synopsis
- Research shows that per- and polyfluoroalkyl substances (PFASs) have possible links to various health issues, but more studies are needed for conclusive findings.
- A systematic review examined 157 meta-analyses assessing PFAS health impacts, indicating moderate-to-high quality results for most studies, particularly highlighting significant associations with low birth weight and immune response.
- While strong evidence connects some PFASs to specific health outcomes, many associations still lack certainty, with a substantial number of potential health effects needing further investigation.
Role of artificial intelligence in digital pathology for gynecological cancers.
Comput Struct Biotechnol J
December 2024
The diagnosis of cancer is typically based on histopathological sections or biopsies on glass slides. Artificial intelligence (AI) approaches have greatly enhanced our ability to extract quantitative information from digital histopathology images as a rapid growth in oncology data. Gynecological cancers are major diseases affecting women's health worldwide.
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- The study examines the relationship between ultra-processed food (UPF) consumption and the risk of metabolic diseases like obesity and type 2 diabetes, aiming to provide clarity for dietary guidelines.
- It involves a systematic review of multiple databases, analyzing six systematic reviews and 13 meta-analyses to evaluate the strength of this association and the credibility of the evidence.
- Findings indicate that higher consumption of UPF is linked to a significantly increased risk of both obesity and type 2 diabetes, suggesting that reducing UPF intake could be beneficial for metabolic health.
Platinum-based chemotherapy remains one of the major choices for treatment of ovarian cancer (OC). However, primary or acquired drug resistance severely impairs their efficiency, thereby causing chemotherapy failure and poor prognosis. SH3 domain containing ring finger 2 (SH3RF2) has been linked to the development of cancer.
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- This study analyzes the proteomic profiles of three main types of epithelial ovarian cancer (Clear cell carcinoma, Endometrioid carcinoma, and Serous carcinoma) using 80 samples of CCC, 79 samples of EC, and 80 samples of SC, along with 30 control samples.
- The research identifies significant differences in protein expression and phosphorylation that could help in diagnosing and predicting outcomes for each cancer subtype.
- Importantly, the findings suggest that MPP7 protein could serve as a potential therapeutic target for Serous carcinoma, enhancing our understanding of the distinct biological features and treatment options for these cancers.
Scope: The study aims to investigate the role of the sulfur microbial diet in the survival of ovarian cancer (OC).
Methods And Results: A prospective cohort study is conducted with 703 patients diagnosed with OC between 2015 and 2020. Diet information is collected using a validated food frequency questionnaire.
Article Synopsis
- Colors of fruits and vegetables (FV) correspond to pigmented bioactive compounds, and a study aimed to examine their impact on ovarian cancer (OC) survival was conducted with 700 newly diagnosed patients.
- Results indicated that higher pre-diagnosis intake of total FV, especially vegetables and red/purple fruits/vegetables, was associated with improved OC survival, while other color groups showed no significant effects.
- The study suggests that consuming green and red/purple FV before diagnosis may enhance OC survival, but further research is needed to confirm these findings.
: Owing to the limited studies and controversial evidence, the connection between diet quality and survival of patients with ovarian cancer (OC) has been indistinct. Our study intends to first investigate this topic based on Chinese diet quality scores. : Our data come from an ovarian cancer follow-up study, which includes 796 patients with OC between 2015 and 2020.
View Article and Find Full Text PDFBackground: Evidence of the association between particles with a diameter of 2.5 μm or less (PM) in long term and ovarian cancer (OC) mortality is limited.
Methods: This prospective cohort study analyzed data collected between 2015 and 2020 from 610 newly diagnosed OC patients, aged 18-79 years.
The association between non-genetic risk factors and cervical cancer (CC) remains controversial and unclear. This umbrella review was conducted to evaluate and synthesize previously published systematic reviews and meta-analyses related to non-genetic factors and CC risk. We searched PubMed, Web of Science, and EMBASE to identify studies investigating the association between extragenetic factors and CC risk.
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- Emerging evidence suggests a shift in focus from just the quantity of macronutrients to their quality for better ovarian cancer prognosis.
- A study involving 701 women diagnosed with ovarian cancer showed that a higher macronutrient quality index (MQI) is linked to significantly improved survival rates.
- The findings highlight that not only overall macronutrient quality but also the specific qualities of carbohydrates, fats, and proteins contribute to better outcomes, particularly in individuals struggling with energy imbalances.
Background: The green lacewing Chrysoperla nipponensis is an important natural enemy of many insect pests and exhibits reproductive diapause to overwinter. Our previous studies showed that adult C. nipponensis enters reproductive diapause under a short-day photoperiod.
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