Publications by authors named "Fang-Hong Gong"
[Abnormal Activation of T Cells in HIV-1 Infection After Antiretroviral Therapy].
Sichuan Da Xue Xue Bao Yi Xue Ban
March 2023
Objective: To investigate the relationship between abnormal activation of T cell subsets in peripheral whole blood and the recovery of immune function in persons infected with HIV-1, and to examine the relationship between the size of the viral reservoir of HIV-1 DNA and T cell subsets.
Methods: HIV-1-infected persons who underwent routine testing between July 2019 and May 2020 were the target population of the study. According to whether, at the time of enrollment, their CD4 T cells reached 500 cells/μL after antiretroviral therapy (ART), HIV-1-infected persons were divided into two groups, 76 in the deficiency group and 61 in the immune recovery group.
Article Synopsis
- The study evaluated the diagnostic accuracy of the 1,3-β-D-glucan (BDG) assay for invasive fungal infections (IFI) by analyzing data from 28 studies, with 896 patients confirmed positive for IFI.
- The pooled results showed a sensitivity of 78%, specificity of 81%, and a significant diagnostic odds ratio, with a summary receiver operating characteristic (SROC) curve area of 0.8855, indicating strong test performance.
- For optimal diagnostic accuracy, the study recommends using a BDG cutoff value of 60 pg/mL, particularly aligning with the European Organization for Research and Treatment of Cancer/Mycoses Study Group's criteria.