FAM129A promotes invasion and proliferation by activating FAK signaling pathway in non-small cell lung cancer.

Family with sequence similarity 129, member A (FAM129A), also called Niban or C1orf24, was initially identified from a rat model of hereditary renal carcinoma. FAM129A inhibited apoptosis and promoted migration and proliferation in human cancers. However, little is known about the downstream signaling during tumor progression.

TRIM22 confers poor prognosis and promotes epithelial-mesenchymal transition through regulation of AKT/GSK3β/β-catenin signaling in non-small cell lung cancer.

Expression pattern and biological roles of TRIM22 remains unknown in most human cancers. The present study aims to discover its clinical significance and function in human non-small cell lung cancer (NSCLC). Immunohistochemistry was used to examine TRIM22 expression in 126 cases of NSCLC specimens.

Primary tracheobronchial non-Hodgkin lymphoma causing life-threatening airway obstruction: a case report.

Primary tracheobronchial non-Hodgkin lymphoma (NHL) is a rare tracheobronchial tumor that typically presents as an endobronchial mass and/or mucosal infiltration together with lymphadenopathy. Here we report a case of primary tracheobronchial NHL which was confirmed by histopathological analysis of the endobronchial biopsy specimens. We initially could not treat with chemotherapy because the life-threatening obstruction of the bilateral main bronchi caused by NHL.