T cell-mediated tumor killing sensitivity gene signature-based prognostic score for acute myeloid leukemia.

Background And Objective: Acute myeloid leukemia (AML) is an aggressive, heterogenous hematopoetic malignancies with poor long-term prognosis. T-cell mediated tumor killing plays a key role in tumor immunity. Here, we explored the prognostic performance and functional significance of a T-cell mediated tumor killing sensitivity gene (GSTTK)-based prognostic score (TTKPI).

Association of preschool children behavior and emotional problems with the parenting behavior of both parents.

Background: Parental behaviors are key in shaping children's psychological and behavioral development, crucial for early identification and prevention of mental health issues, reducing psychological trauma in childhood.

Aim: To investigate the relationship between parenting behaviors and behavioral and emotional issues in preschool children.

Methods: From October 2017 to May 2018, 7 kindergartens in Ma'anshan City were selected to conduct a parent self-filled questionnaire - Health Development Survey of Preschool Children.

Effectiveness of Tuina Therapy Combined With Yijinjing Exercise in the Treatment of Nonspecific Chronic Neck Pain: A Randomized Clinical Trial.

Importance: Both tuina therapy and yijinjing exercise were beneficial to patients with nonspecific chronic neck pain, but the evidence for this combination is limited.

Objective: To investigate the effectiveness of tuina therapy combined with yijinjing exercise compared with tuina therapy alone for patients with nonspecific chronic neck pain.

Design, Setting, And Participants: A 12-week, open-label, analyst-blinded randomized clinical trial (8-week intervention plus 4-week observational follow-up) was conducted from September 7, 2020, to October 25, 2021.

Carbene Addition Isomers of C formed in the Flame of Low-Pressure Combustion.

In the flames during low-pressure combustion, not only a rich variety of fullerenes but also many reactive intermediates can be produced (e.g., carbene, CH) that are short-lived and cannot be stabilized directly under normal circumstances.

Molecular Tweezer Based on Perylene and Crown Ether for Selective Recognition of Fullerenes.

A molecular tweezer -di(perylene-3-ylmethanaminobenzo)-18-crown-6 (DP-18C6) incorporating two perylene subunits in a single crown ether core was designed and synthesized as a host for fullerenes. Through the cooperative effect of the perylene subunits and the crown ether moiety, DP-18C6 can efficiently recognize fullerenes including C, C, and C. H NMR titration and fluorescence titration experiments demonstrated that DP-18C6 can effectively grasp the fullerene molecule to form a 1:1 host-guest complex.

Capturing nonclassical C with double heptagons in low-pressure combustion.

A double-heptagon-containing CH (dihept-CH) was isolated and unambiguously characterized in the soot of low-pressure combustion, which shares the identical heptagonal cage as dihept-CCl previously identified in the products of carbon arc, and thus represents the first nonclassical fullerene isolable in both carbon arc and combustion.

Sulfur-Doped Quintuple [9]Helicene with Azacorannulene as Core.

Herein, a hetero(S,N)-quintuple [9]helicene (SNQ9H) molecule with an azacorannulene core was synthesized, currently representing the highest hetero-helicene reported in the field of multiple [n]helicenes. X-ray crystallography indicated that SNQ9H includes not only a propeller-shaped conformer SNQ9H-1, but also an unforeseen quasi-propeller-shaped conformer SNQ9H-2. Different conformers were observed for the first time in multiple [n≥9]helicenes, likely owing to the doping of heteroatomic sulfurs in the helical skeletons.

Radiomic-Based MRI for Classification of Solitary Brain Metastases Subtypes From Primary Lymphoma of the Central Nervous System.

Background: Differential diagnosis of brain metastases subtype and primary central nervous system lymphoma (PCNSL) is necessary for treatment decisions. The application of machine learning facilitates the classification of brain tumors, but prior investigations into primary lymphoma and brain metastases subtype classification have been limited.

Purpose: To develop a machine-learning model to classify PCNSL, brain metastases with primary lung and non-lung origin.

Synthesis and Fluorescent Properties of Multi-Functionalized C Derivatives of C(OCH)[C(COOEt)] and C(OCH)[C(COOEt)].

Due to the partially reduced π-conjugation of the fullerene cage, multi-functionalized fullerene derivatives exhibit remarkable fluorescent properties compared to pristine fullerenes, which have high potential for application in organic light-emitting diodes (OLEDs). In this study two multi-functionalized C derivatives, C(OCH)[C(COOEt)] and C(OCH)[C(COOEt)], with excellent fluorescence properties, were designed and synthesized. Compared with C(OCH) containing a single kind of functional group, both the C(OCH)[C(COOEt)] and C(OCH)[C(COOEt)] exhibited enhanced fluorescence properties with blue fluorescence emission.

Tailoring Functional Terminals on Solution-Processable Fullerene Electron Transporting Materials for High Performance Perovskite Solar Cells.

Widely known as an excellent electron transporting material (ETM), pristine fullerene C plays a critical role in improving the photovoltaic performance of inverted structure perovskite solar cells (PSCs). However, the imperfect perovskite/C interface significantly limits the promotion of device performance and stability due to the weak coordination interactions between bare carbon cages and perovskite. Here, we designed and synthesized three functionalized fulleropyrrolidine ETMs (abbreviated as CEP, CEPE, and CECB), each of which was modified with the same primary terminal (cyanoethyl) and various secondary terminals (phenyl, phenethyl, and chlorobutyl).

A chromosome-scale genome sequence of pitaya (Hylocereus undatus) provides novel insights into the genome evolution and regulation of betalain biosynthesis.

Pitaya (Hylocereus) is the most economically important fleshy-fruited tree of the Cactaceae family that is grown worldwide, and it has attracted significant attention because of its betalain-abundant fruits. Nonetheless, the lack of a pitaya reference genome significantly hinders studies focused on its evolution, as well as the potential for genetic improvement of this crop. Herein, we employed various sequencing approaches, namely, PacBio-SMRT, Illumina HiSeq paired-end, 10× Genomics, and Hi-C (high-throughput chromosome conformation capture) to provide a chromosome-level genomic assembly of 'GHB' pitaya (H.

A Gd@C single-molecule electret.

Electrets are dielectric materials that have a quasi-permanent dipole polarization. A single-molecule electret is a long-sought-after nanoscale component because it can lead to miniaturized non-volatile memory storage devices. The signature of a single-molecule electret is the switching between two electric dipole states by an external electric field.

Mixed Fullerene Electron Transport Layers with Fluorocarbon Chains Assembling on the Surface: A Moisture-Resistant Coverage for Perovskite Solar Cells.

In structure perovskite solar cells (PSCs), the most prevalent electron transport layer (ETL), [6, 6]-phenyl-C-butyric acid methyl ester (PCBM), acts as both electron extractor and protective coverage to the underlayer perovskite. Notably, multifunctional mixed fullerene ETLs show great potential in further improving both the power conversion efficiency (PCE) and stability of PSCs compared to the single PCBM ETL. In this work, we reported the mixed fullerene ETLs comprising of PCBM and its two analogs with different length of fluorocarbon chains, [6, 6]-phenyl-C-buryric acid 1H,1H-trifluoro-1-ethyl ester (abbreviated, CF-PCBM) and [6, 6]-phenyl-C-buryric acid 1H, 1H-tridecafluoro-1-heptyl ester (abbreviated, CF-PCBM).

Contact Time of a Bouncing Nanodroplet.

We study the bouncing dynamics of nanodroplets on superhydrophobic surfaces. We show that there are three velocity regimes with different scaling laws of the contact time, τ. Although τ remains constant over a wide velocity range, as seen for macroscale bouncing, we demonstrate that viscosity plays an essential role in nanodroplet bouncing even for low-viscosity fluids.

Flexible bronchoscopy-guided microwave ablation in peripheral porcine lung: a new minimally-invasive ablation.

Background: Transbronchial lung biopsy is an important approach to diagnose peripheral lung cancer, but bronchoscopy based treatment options are limited and poorly studied. A flexible bronchoscopy-guided water-cooled microwave ablation (MWA) catheter was developed to evaluate the feasibility and safety both in and porcine models.

Methods: Using direct penetration of the catheter through the surface of porcine lung, ablations (n=9) were performed at 70, 80, 90 W for 10 minutes.

Rational synthesis of an atomically precise carboncone under mild conditions.

Carboncones, a special family of all-carbon allotropes, are predicted to have unique properties that distinguish them from fullerenes, carbon nanotubes, and graphenes. Owing to the absence of methods to synthesize atomically well-defined carboncones, however, experimental insight into the nature of pure carboncones has been inaccessible. Herein, we describe a facile synthesis of an atomically well-defined carboncone[1,2] (CH) and its soluble penta-mesityl derivative.

Enhancement of Coalescence-Induced Nanodroplet Jumping on Superhydrophobic Surfaces.

Coalescence-induced droplet self-jumping on superhydrophobic surfaces has received extensive attentions over the past decade because of its potential applications ranging from anti-icing materials to self-sustained condensers, in which a higher jumping velocity v is always expected and favorable. However, the previous studies have shown that there is a velocity limit with v ≤ 0.23 u for microscale droplets and v ≤ 0.

Coalescence-Induced Jumping of Two Unequal-Sized Nanodroplets.

Coalescence-induced self-propelled jumping of droplets on superhydrophobic surfaces has potential applications for condensation heat transfer enhancement, anti-icing, self-cleaning, antidew, and so forth. However, most of the previous studies focused on two identical droplets which are not commonly encountered in the nature. In this work, coalescence-induced jumping phenomena of two unequal-sized droplets on superhydrophobic surfaces were investigated theoretically and numerically.

[Evaluation of the cavity cleaning of ultrasonic instruments and slow-speed handpiece in posterior teeth root-end preparation].

Purpose: To compare the cleanliness of root end preparations by using ultrasonic instrumentation and slow-speed handpiece.

Methods: Thirty-two mesial roots of the first mandibular molars with two canals and mature root apices were assigned randomly to 2 groups, each group had 16 teeth. The root-end preparations were made respectively using ultrasonic diamond tip Berutti and NiTi tip RE2 and slow-speed handpiece with No.

[FTIR analysis of oil shales from Huadian Jilin and their pyrolysates].

Thermochemical conversion is the key technology for the comprehensive utilization of Chinese oil shale resources. Oil shales from three mining areas of Huadian Jilin were pyrolyzed at 500 degrees C in a quartz tube reactor and their pyrolyzed cokes and shale oil were derived. One oil shale was also pyrolyzed at 600 degrees C and 700 degrees C to assess the influence of temperature on pyrolysates.

[Effects of different instruments in root-end preparation: scanning electron microscopic evaluation].

Purpose: To evaluate the effects of retrograde preparation between ultrasonic retrotips and traditional slow-speed handpiece.

Methods: 27 maxillary second bicuspid teeth with two canals and one isthmus were divided randomly into 3 groups with 9 in each. The root-end preparations were made respectively using ultrasonic diamond tip Berutti and NiTi tip RE2, ultrasonic #40K file and slow-speed handpiece with NO.

[Expressions of Fas/FasL and granzyme B in oral lichen planus and their significance].

Objective: To define the association of the expressions of Fas/FasL and granzyme B with cell apoptosis in oral lichen planus (OLP) and progression of the disease.

Method: Immunohistochemical method and TUNEL were employed to study the expressions of Fas, FasL and granzyme B and cell apoptosis in 50 OLP cases (including 20 cases of atrophic-erosive OLP and 30 nonerosive OLP cases) and 10 normal oral mucosa specimens.

Results: Compared with the control group, the OLP cases showed increased apoptotic index (AI, 95.