Multiwalled Carbon Nanotubes Induce Fibrosis and Telomere Length Alterations.

Telomere shortening can result in cellular senescence and in increased level of genome instability, which are key events in numerous of cancer types. Despite this, few studies have focused on the effect of nanomaterial exposure on telomere length as a possible mechanism involved in nanomaterial-induced carcinogenesis. In this study, effects of exposure to multiwalled carbon nanotubes (MWCNT) on telomere length were investigated in mice exposed by intrapleural injection, as well as in human lung epithelial and mesothelial cell lines.

Inflammation in the pleural cavity following injection of multi-walled carbon nanotubes is dependent on their characteristics and the presence of IL-1 genes.

Upon inhalation, multi-walled carbon nanotubes (MWCNTs) may reach the subpleura and pleural spaces, and induce pleural inflammation and/or mesothelioma in humans. However, the mechanisms of MWCNT-induced pathology after direct intrapleural injections are still only partly elucidated. In particular, a role of the proinflammatory interleukin-1 (IL-1) cytokines in pleural inflammation has so far not been published.

Retraction: The Predictors of the Job Stress among Female Married Hospital Nurses.

This article has been retracted by the Editorial Board of INDUSTRIAL HEALTH due to violation of our publishing policies and procedures as of September 26, 2014.

The Predictors of the Job Stress among Female Married Hospital Nurses.

The purposes of this study were to explore the relationships among family stress, social support and job stress in female married hospital nurses. Married female nurses had to face both paid hospital work and unpaid domestic work, and double workloads might lead to more stress of female married nurses. Most studies were limited to explore the correlations of job stresses caused from jobs only, and ignored the affecting factors from family stresses.

[Increasing patient family member satisfaction with information received from a post-anesthesia care unit].

Background: Families of patients in post-anesthesia care units (PACUs), often feel anxious because of a lack of information on patient condition and post-operative care. Based on interviews with families, we designed a family information needs questionnaire to measure family information needs, satisfaction with information received, satisfaction with post-operative care, and level of perceived anxiety. Results of a questionnaire survey taken in March 2011 revealed an average satisfaction-level score of 75.

Effect of insulin and contraction on glycogen synthase phosphorylation and kinetic properties in epitrochlearis muscles from lean and obese Zucker rats.

In the present study, the effects of insulin and contraction on glycogen synthase (GS) kinetic properties and phosphorylation were investigated in epitrochlearis muscles from lean and obese Zucker rats. Total GS activity and protein expression were ~15% lower in epitrochlearis from obese rats compared with lean rats. Insulin-stimulated GS fractional activity and affinity for UDP-glucose were lower (higher K(m)) in muscles from obese rats.

Beta-adrenoceptor stimulation potentiates insulin-stimulated PKB phosphorylation in rat cardiomyocytes via cAMP and PKA.

Background And Purpose: Genetic approaches have documented protein kinase B (PKB) as a pivotal regulator of heart function. Insulin strongly activates PKB, whereas adrenaline is not considered a major physiological regulator of PKB in heart. In skeletal muscles, however, adrenaline potentiates insulin-stimulated PKB activation without having effect in the absence of insulin.