TXN promotes tumorigenesis by activating the ERK1/2 and ERK5 signaling pathways regulating c-Myc in non-small cell lung cancer.

Lung cancer is the primary cause of cancer-related deaths worldwide, particularly for non-small cell lung cancer (NSCLC). However, the exact mechanism underlying tumor formation remains unclear. It is widely acknowledged that inflammation and oxidative stress occur in the tumor microenvironment, promoting cell malignant growth and metastasis.

Cation Migration-Induced Lattice Oxygen Oxidation in Spinel Oxide for Superior Oxygen Evolution Reaction.

Activating the lattice oxygen can significantly improve the kinetics of oxygen evolution reaction (OER), however, it often results in reduced stability due to the bulk structure degradation. Here, we develop a spinel FeCoCrO with active lattice oxygen by high-throughput methods, achieving high OER activity and stability, superior to the benchmark IrO. The oxide exhibits an ultralow overpotential (190 mV at 10 mA cm) with outstanding stability for over 170 h at 100 mA cm.

Extremely rapid, yet noncatastrophic, preservation of the flattened-feathered and 3D dinosaurs of the Early Cretaceous of China.

Northeast China's Early Cretaceous Yixian Formation preserves spectacular fossils that have proved extraordinarily important in testing evolutionary hypotheses involving the origin of birds and the distribution of feathers among nonavian dinosaurs. These fossils occur either flattened with soft tissue preservation (including feathers and color) in laminated lacustrine strata or as three-dimensional (3D) skeletons in "life-like" postures in more massive deposits. The relationships of these deposits to each other, their absolute ages, and the origin of the extraordinary fossil preservation have been vigorously debated for nearly a half century, with the prevailing view being that preservation was linked to violent volcanic eruptions or lahars, similar to processes that preserved human remains at Pompeii.

Prothrombin deficiency with recurrent subretinal hemorrhage.

Ocular hemorrhage has been recorded in congenital factor deficiencies like hemophilia A, but it has never been documented in prothrombin deficiency. Here, we describe an unusual case of sudden vision loss in the right eye caused by subretinal hemorrhage following a coughing episode in a 67-year-old woman. Notably, the patient underwent left eye enucleation 12 years previously under similar circumstances due to subretinal hemorrhage.

IgG4 plasma cell neoplasm in liver transplant biopsy masquerading as rejection.

IgG4 plasma cell neoplasm and myeloma are rare disease entities, not associated with systemic fibroinflammatory IgG4 related disease. We herein present a case of IgG4 plasma cell neoplasm in a liver transplant biopsy. A 55 year old female was treated with living donor transplant and had a complicated post-operative course.

Acute myeloid leukemias with JAK2/STAT mutations are associated with PD-L1 upregulation.

Even though overexpression of the immune checkpoint protein, programmed cell death ligand-1 (PD-L1), is observed in solid tumors, its expression patterns in acute myeloid leukemia remain understudied. As activation of the JAK/STAT pathway has been shown to enhance PD-L1 expression in preclinical models, we evaluated biopsies from AML patients with activating mutations in JAK2/STATs. PD-L1 expression was significantly upregulated in JAK2/STAT mutant cases when compared to JAK2 wildtype controls as demonstrated by PD-L1 immunohistochemistry staining and quantified using the combined positive score (CPS) system.

Global Longitudinal Strain Is Associated with Mortality in Patients with Multiple Myeloma.

Patients with multiple myeloma (MM) are at a high risk for developing cardiovascular complications. Global longitudinal strain (GLS) can detect early functional impairment before structural abnormalities develop. It remains unknown if reduced GLS is associated with reduced survival in patients with MM.

Phase evolution and arsenic immobilization of arsenate-bearing amorphous calcium phosphate.

The formation of As(V) substituted hydroxylapatite (HAP) has a vital influence on the fate of As(V) in the environment. However, despite growing evidence showing that HAP crystallizes in vivo and in vitro with amorphous calcium phosphate (ACP) as a precursor, a knowledge gap exists concerning the transformation from arsenate-bearing ACP (AsACP) to arsenate-bearing HAP (AsHAP). Here we synthesized AsACP nano-particles with varied As contents and investigated the arsenic incorporation during their phase evolution.

Identification of thioredoxin-1 as a biomarker of lung cancer and evaluation of its prognostic value based on bioinformatics analysis.

Background: Thioredoxin-1 (TXN), a redox balance factor, plays an essential role in oxidative stress and has been shown to act as a potential contributor to various cancers. This study evaluated the role of TXN in lung cancer by bioinformatics analyses.

Materials And Methods: Genes differentially expressed in lung cancer and oxidative stress related genes were obtained from The Cancer Genome Atlas, Gene Expression Omnibus and GeneCards databases.

How to Make Primary Healthcare More Popular: Evidence from the Middle-Aged and Elderly in China.

Since 2001, China has been an aging society; it is expected to become superaged by 2033. This rapid aging trend poses a challenge to the elderly regarding their pension services and healthcare. Primary healthcare has great potential for serving older adults in the community, yet it is not popular.

Orthovoltage X-Rays Exhibit Increased Efficacy Compared with γ-Rays in Preclinical Irradiation.

Unlabelled: Radionuclide irradiators (137Cs and 60Co) are commonly used in preclinical studies ranging from cancer therapy to stem cell biology. Amidst concerns of radiological terrorism, there are institutional initiatives to replace radionuclide sources with lower energy X-ray sources. As researchers transition, questions remain regarding whether the biological effects of γ-rays may be recapitulated with orthovoltage X-rays because different energies may induce divergent biological effects.

A powder XRD, solid state NMR and calorimetric study of the phase evolution in mechanochemically synthesized dual cation (Cs(CHNH))PbX lead halide perovskite systems.

Methylammonium (MA) lead halide perovskites (MAPbX) have been widely investigated for photovoltaic applications, with the addition of Cs improving structural and thermal stability. This study reports the complete A site miscibility of Cs and MA cations in the lead chloride and lead bromide perovskites with nominal stoichiometric formulae (CsMA)Pb(Cl/Br) ( = 0, 0.13, 0.

Arctic ice and the ecological rise of the dinosaurs.

Abundant lake ice-rafted debris in Late Triassic and earliest Jurassic strata of the Junggar Basin of northwestern China (paleolatitude ~71°N) indicates that freezing winter temperatures typified the forested Arctic, despite a persistence of extremely high levels of atmospheric co (partial pressure of CO). Phylogenetic bracket analysis shows that non-avian dinosaurs were primitively insulated, enabling them to access rich deciduous and evergreen Arctic vegetation, even under freezing winter conditions. Transient but intense volcanic winters associated with massive eruptions and lowered light levels led to the end-Triassic mass extinction (201.

The healthcare inequality among middle-aged and older adults in China: a comparative analysis between the full samples and the homogeneous population.

Background: In the Chinese population, the middle-aged and older adults are the two main segments that utilize a large portion of healthcare. With the fast growth of the two segments, the demands of healthcare services increases significantly. The issue related to inequality in utilization of healthcare emerges with the growth and it deserves more attention.

Composition-tuned MAPbBr nanoparticles with addition of Cs cations for improved photoluminescence.

Hybrid organic-inorganic lead halide perovskite nanoparticles are promising candidates for optoelectronic applications. This investigation describes the structural and optical properties of MA Cs PbBr mixed cation colloidal nanoparticles spanning the complete compositional range of Cs substitution. A monotonic progression in the cubic lattice parameter () with changes in the Cs content confirmed the formation of mixed cation materials.

Structure and surface properties of size-tuneable CsPbBr nanocrystals.

This investigation has characterised the structure and surface chemistry of CsPbBr nanocrystals with controlled diameters between 6.4 to 12.8 nm.

Controllable Solution-Phase Epitaxial Growth of Q1D Sb (S,Se) /CdS Heterojunction Solar Cell with 9.2% Efficiency.

Antimony sulfoselenide (Sb (S,Se) ) is a promising photoabsorber for stable and high efficiency thin film photovoltaics (PV). The unique quasi-1D (Q1D) crystal structure gives Sb (S,Se) intriguing anisotropic optoelectronic properties, which intrinsically require the optimization of crystal growth orientation, especially for electronic devices with vertical charge transport such as solar cells. Although the efficiency of Sb (S,Se) solar cells has been improved greatly through optimizing the material quality, the fundamental issue of crystal orientation control in polycrystalline films remains unsolved, resulting in charge carrier recombination losses in the device.

Characterisation of Geogrid and Waste Tyres as Reinforcement Materials in Railway Track Beds.

The engineering behaviour of ballast is an important factor to determine the stability and safety of railway tracks. This paper examines the stress-strain, shear strength, peak deflection stress and reinforcement strength ratio of different reinforcement materials and reinforcement locations in ballast track bed layers based on large scale static triaxial shear tests. The results show that geogrid and waste tyre reinforcement have a significant effect on the peak deviator stress of railway track bed layers and the stress-strain relationship is strain-hardened.

Room temperature synthesis of low-dimensional rubidium copper halide colloidal nanocrystals with near unity photoluminescence quantum yield.

Metal lead halide perovskite nanocrystals have emerged as promising candidates for optoelectronic applications. However, the inclusion of toxic lead is a major concern for the commercial viability of these materials. Herein, we introduce a new family of non-toxic reduced dimension RbCuX (X = Br, Cl) colloidal nanocrystals with one-dimensional crystal structure consisting [CuX] ribbons isolated by Rb cations.

A Rare CD4-CD8+ Adult T-Cell Leukemia/Lymphoma with Unique Molecular Mutations: A Case Report with Literature Review.

Adult T-cell leukemia/lymphoma (ATLL) is a mature T-cell neoplasm caused by infection of the human T-cell lymphotropic virus type 1 (HTLV-1). Most ATLL cases are CD4-positive and CD8-negative. Though rare, there are a few dual negative (CD4-CD8-), dual positive (CD4+CD8+), and CD4-CD8+ cases reported in literature.

Manipulating efficient light emission in two-dimensional perovskite crystals by pressure-induced anisotropic deformation.

The hybrid nature and soft lattice of organolead halide perovskites render their structural changes and optical properties susceptible to external driving forces such as temperature and pressure, remarkably different from conventional semiconductors. Here, we investigate the pressure-induced optical response of a typical two-dimensional perovskite crystal, phenylethylamine lead iodide. At a moderate pressure within 3.

Crystal Chemistry and Antibacterial Properties of Cupriferous Hydroxyapatite.

Copper-doped hydroxyapatite (HA) of nominal composition Ca(PO)[Cu(OH)O] (0.0 ≤ x ≤ 0.8) was prepared by solid-state and wet chemical processing to explore the impact of the synthesis route and mode of crystal chemical incorporation of copper on the antibacterial efficacy against () and () strains.