Factors influencing occupational burnout among palliative care practitioners in China.

Objective: The aim of this investigation was to examine the job burnout status among health practitioners in palliative care wards within a specific province of China and to analyze associated factors.

Methods: A multicenter cross-sectional study design was utilized from August to October 2023,enrolling 164 health practitioners from 9 hospitals within the palliative care wards of the specified province. Data collection involved anonymous questionnaires covering basic personal information, job characteristics, and levels of occupational burnout.

microRNA-30c attenuates contrast-induced acute kidney injury by reducing renal tubular epithelial cell apoptosis via targeting SOCS1.

Contrast-induced acute kidney injury (CIAKI) is a common complication after contrast media administration. Growing evidences implicate microRNA (miR)-30c has a key role in renal diseases. This study aimed to investigate the role and mechanism of miR-30c in CIAKI.

The effects of QC08 on reducing uric acid level and providing renal protection in mice with hyperuricemia.

Objective: The present study aimed to investigate the uric acid-lowering effects of QC08 and explore its underlying mechanisms.

Methods: Hyperuricemia (HUA) model in mice was established using potassium oxonate (250 mg/kg) and yeast extract (15 g/kg). The serum levels of uric acid (UA), blood urea nitrogen (BUN), creatinine (Cr), and liver xanthine oxidase (XO) were measured in four groups, including normal group, control group, allopurinol group (5 mg/kg), and QC08 group (10 CFU/kg) using enzyme colorimetry.

BB05 alleviates depressive symptoms in mice via the AKT/mTOR pathway.

Introduction: This study investigates the potential of BB05 (BB05) in mitigating depressive symptoms in a mouse model of Chronic Unpredictable Mild Stress (CUMS), with fluoxetine as a positive control.

Methods And Results: High-dose BB05 (1.0 × 10 CFU/kg, BB05H) significantly reduced anxiety- and depression-like behaviors in CUMS mice, as measured by the open field test, tail suspension test, and forced swim test.

Electron paramagnetic resonance and photoluminescence study on local structure of Gd ions in Gd-doped CaF crystals.

Employing electron paramagnetic resonance (EPR) and excitation and photoluminescence (PL) spectra, changes of the local structure of Gd ions were investigated for the CaF crystals containing 0.00015, 0.17, 1.

A new method to predict refracture risk after locking compression plate removal of clavicle shaft.

Background: The incidence rate of subsequent refracture after removal of the implant in mid-shaft clavicle fracture patients is relatively high. This can lead to additional medical costs and cause doctor-patient dispute. This study tries to introduce a new method to predict the refracture risk of the clavicle after hardware removal.

Job burnout and resilience among palliative care professionals in china: a qualitative study.

Background: Medical professionals who are engaged in palliative care commonly experience negative emotions resulting from the pain and grief experienced by patients and family members, which results in enormous psychological pressure for professionals, and the risk related to job burnout is significantly greater.

Objective: We aimed to explore the factors influencing job burnout and resilience among palliative care professionals.

Methods: We conducted a qualitative study using semistructured interviews and purposeful sampling methods.

Therapeutic Effect of HFY11 Isolated from Naturally Fermented Yak Yogurt on Lincomycin Hydrochloride-Induced Diarrhea in Mice.

This study aimed to observe the therapeutic effect of HFY11 (LP-HFY11) on lincomycin hydrochloride-induced diarrhea in mice. The results showed that LP-HFY11 alleviated weight loss and intestinal and colon tissue lesions caused by diarrhea. The serum assay showed that LP-HFY11 decreased interleukin 17A (IL-17A), IL-6, 5-hydroxytryptamine, and malondialdehyde levels and increased total antioxidant capacity in mice with diarrhea.

Clinical results of helical tomotherapy for high-grade gliomas.

Introduction: Radiotherapy-related damage of normal tissue inevitably influences the treatment outcomes in the context of high-grade gliomas (HGGs) treatment. We reported the survival outcomes and toxicities of patients with HGG treated with helical tomotherapy (HT) and the prognostic factors were analyzed.

Materials And Methods: A total of 67 patients (29 had grade III and 38 had grade IV HGGs) who received HT between January 2016 and June 2020 were analyzed.

Efficient removal of aqueous ciprofloxacin antibiotic by ZnO/CuO-bentonite composites synthesized via carbon-bed pyrolysis of bentonite and metal co-precipitation.

Antibiotics are of emerging concern due to their widespread use, lack of adequate treatment, and for their potential to threaten human health and the environment. Here, a facile fabrication approach for synthesizing ZnO/CuO-bentonite composites was investigated via carbon-bed pyrolysis of bentonite followed by ZnO/CuO co-precipitation. Sorbents were synthesized using a range of bentonite pyrolysis temperatures, metal oxide contents, and ZnO:CuO mass ratios.

The Selectively Nontargeted Analysis of Halogenated Disinfection Byproducts in Tap Water by Micro-LC QTOFMS.

With the rapid development of society, more and more unknown halogenated disinfection byproducts (DBPs) enter into drinking water and pose potential risks to humans. To explore the unknown halogenated DBPs in tap water, a selectively nontargeted analysis (SNTA) method was developed by conducting micro-liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (micro-LC-QTOFMS). In this method, two runs were employed: in the first run, the modes of and (the fragments were set as Cl/Cl, Br/Br, and I) were performed, and the molecular ions or precursor ions of the halogenated organics could be obtained; in the second run, the mode was conducted by setting the molecular ion screened above, and the MS/MS spectrums could be acquired to speculate concerning the structure.

Patient Assessment of Chronic Illness Care (PACIC) and Its Influence on Patient Compliance With Hypertension: A Cross-Sectional Study.

The Chronic Care Model (CCM) is a framework that supports the proactive, planned, coordinated and patient-centered care of chronic diseases. The Patient Assessment of Chronic Illness Care (PACIC) scale is a valuable tool for evaluating patients' perspectives on chronic care delivery based on the CCM. Few studies have examined its application in China.

Signal amplification in molecular sensing by imprinted polymers.

In the field of sensing, the development of sensors with high sensitivity, accuracy, selectivity, sustainability, simplicity, and low cost remains a key focus. Over the past decades, optical and electrochemical sensors based on molecular imprinting techniques have garnered significant attention due to the above advantages. Molecular imprinting technology utilizes molecularly imprinted polymers (MIPs) to mimic the specific recognition capabilities of enzymes or antibodies for target molecules.

Structure and Spectral Properties of Er-Doped Bismuth Telluride Near-Infrared Laser Glasses.

TeO-BiO-BO-ZnO laser glasses doped with Er were synthesized through an optimized melt-quenching method. The absorption spectra at 808 nm LD pumping were studied. Various spectral tests and data analyses indicate that the maximum fluorescence emission intensity can be obtained when the Er doping concentration reaches 2%.

Toxicological safety assessment of a water extract of by a 90-day repeated oral toxicity study in rats.

although known as "Sweet Tea" (ST), has been traditionally accepted as a daily beverage and used as a folk medicine in southern China with little understanding of its potential toxicity. This study evaluated the safety of a water extract of ST by a subchronic toxicity study in Sprague-Dawley rats. A total of 80 rats were randomized divided into 4 groups with 10 males and 10 females in each group, treated with 2000, 1,000, 500 and 0 mg/kg body weight of ST extract by gavage for 90 days, respectively.

Picosecond laser-driven coded-source radiography with high resolution and contrast.

The X-ray sources for Compton radiography of ICF experiments are generated by using intense picosecond lasers to irradiate wire targets. The wire diameter must be designed thin enough, for example ∼ 10 µm in many published works, to comply a high spatial resolution. This results in a low laser-target interception, which limits the photon yield.

Discharge Under Sedated Status can Decrease Postoperative Emergence Agitation in Pediatric Patients Undergoing Strabismus Surgery: A Prospective Randomized Controlled Trial.

Purpose: Emergence agitation (EA) is a frequent complication during emergence. The researchers aimed to investigate whether discharged pediatric patients from the postanesthesia care unit (PACU) to wards under sedated status could reduce the incidence of EA.

Design: Prospective randomized controlled study.

Treasure-bowl style bifunctional site in cerium-tungsten hetero-clusters for superior solar-driven hydrogen production.

Electrochemical water splitting powered by renewable energy sources hold potential for clean hydrogen production. However, there is still persistent challenges such as low solar-to-hydrogen conversion efficiency and sluggish oxygen evolution reactions. Here, we address the poor kinetics by studying and strengthening the coupling between Ce and W, and concurrently establishing Ce-W bi-atomic clusters on P,N-doped carbon (WN/WC-CeO@PNC) with a "treasure-bowl" style.

Effect of HFY11 on Colitis in Mice.

This study aimed to examine the potential impact of the intervention of HFY11 (LP-HFY11) on colitis using in vivo animal trials. The impact of LP-HFY11 intervention on colitis was determined by measuring the levels of relevant indicators in the intestine, colon, and blood after oxazolone-induced colitis in BALB/c mice. The results of the trial show that LP-HFY11 improved the colon weight-to-length ratio, reduced the colitis-induced colon length shortening, and reduced colonic abstinence.

Dynamic flyer in barrel imaging via high intensity short-pulse laser.

The thin flyer is a small-scale flying object, which is well known as the core functional element of the initiator. Understanding how flyers perform has been a long-standing issue in detonator science. However, it remains a significant challenge to explore how the flyer is formed and functions in the barrel of the initiator via tabletop devices.

[Analysis of effectiveness of one-hole split endoscopy technique in treatment of lumbar spinal stenosis].

Objective: To investigate the effectiveness of one-hole split endoscope (OSE) technique in the treatment of single segment lumbar spinal stenosis (LSS).

Methods: The clinical data of 32 single segment LSS patients treated with OSE technique for simple spinal canal decompression between January 2022 and December 2022, who met the selection criteria, were retrospectively analysed. There were 18 males and 14 females, the age ranged from 45 to 82 years, with an average of 65.

Survival outcomes and treatment experience of 124 patients with primary central nervous system lymphoma.

Purpose: Primary central nervous system lymphoma (PCNSL) is a rare malignancy of the central nervous system with high invasiveness. There is little consensus on the treatment of PCNSL. This study retrospectively studied data from PCNSL patients in a single center to summarize treatment experience and explore prognostic factors.

Study on settlement prediction of soft ground considering multiple feature parameters based on ISSA-RF model.

By collecting a large amount of data from various preloading engineering projects, a settlement prediction database was established including up to 15 feature parameters, such as final measured time, magnitude of surcharge loading, porosity ratio, internal friction angle, and others. Furthermore, a settlement prediction model of soft foundation based on random forest (RF) model was also developed. To enhance the accuracy of settlement prediction, the improved sparrow search algorithm (ISSA), which incorporates several enhancements such as the use of Logistic-tent chaotic mapping, adaptive nonlinear inertia-decreasing weight parameters, and Levy flight strategy, was proposed to optimize the hyperparameters of the RF model.

A Strategy based on Bioinformatics and Machine Learning Algorithms Reveals Potential Mechanisms of Shelian Capsule against Hepatocellular Carcinoma.

Background: Hepatocellular carcinoma (HCC) is a prevalent and life-threatening form of cancer, with Shelian Capsule (SLC), a traditional Chinese medicine (TCM) formulation, being recommended for clinical treatment. However, the mechanisms underlying its efficacy remain elusive. This study sought to uncover the potential mechanisms of SLC in HCC treatment using bioinformatics methods.