Publications by authors named "Fang Sun"

In this case report, we presented a unique instance of varicella in a 35-year-old male, characterized by both gastrointestinal and skin involvement. This case highlights the importance of recognizing varicella's atypical manifestations, particularly in adult patients with gastrointestinal symptoms, ensuring prompt diagnosis and appropriate management.

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Roux-en-Y gastric bypass (RYGB) results in glucose-lowering in patients with type 2 diabetes mellitus (T2DM) and may be associated with increased intestinal glucose excretion. However, the contribution of intestinal glucose excretion to glycemic control after RYGB and its underlying mechanisms are not fully elucidated. Here, we confirmed that intestinal glucose excretion significantly increased in obese rats after RYGB, which was negatively correlated with postoperative blood glucose levels.

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2'-Fucosyllactose (2'-FL), a predominant human milk oligosaccharide, plays a crucial role in the development of the infant gut microbiota and immune system. However, the microbiota of infants with atopic dermatitis (AD) often has difficulty utilizing 2'-FL. Here, we found that strains from human milk, FN120 and subsp.

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Using thiolate-protected Au(SR) nanocluster (NC) with different charge states as the test candidate, how the charge effect affects the etching dynamics of thiolate ligands in acid and the electrocatalytic performance is explored. The ab initio molecular dynamics (AIMD) simulations revealed the charge-dependent reaction kinetics in acid, where the anionic and neutral Au(SCH) (q = -1, 0) favorably react with the acid and partially remove the thiolate ligands via two-step proton attack, while the cationic Au(SCH) NC is acid-resistant with no tendency for -SR removal. Density functional theory (DFT) calculations further predict that the dethiolated Au sites exhibit enhanced catalytic activity for CO electroreduction to CO, with the anionic Au showing significantly superior activity.

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The failure accidents of prestressed concrete cylinder pipe (PCCP) seriously affect the economic feasibility of the construction site. The traditional method of needing to stop construction for pipe inspection is time-consuming and laborious. This paper studies the PCCP broken wire identification algorithm based on deep learning.

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Background: Elizabethkingia infections are caused by the species Elizabethkingia, which recently has become important as a cause of serious infection among neonates and immunocompromised adults. The systematic review summarized clinical data on symptomatic infections caused by Elizabethkingia, including species identification, patient outcomes, and therapeutic approaches.

Methods: The PRISMA guidelines were followed in conducting the systematic review.

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Background: Nasal septum perforation represents a significant clinical concern, with limited investigations into the role of medications in its etiology. This study utilizes the FDA Adverse Event Reporting System (FAERS) database to identify the drugs associated with nasal septum perforation and assess their risk.

Research Design And Methods: This retrospective pharmacovigilance study analyzed drug-induced nasal septum perforation data from January 2004 to December 2023.

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Creating gradient hydrogels for remote control of bionic systems continues to be challenging due to the complexity of the preparation process. Herein, we have proposed a strategy to prepare near-infrared photothermal conversion gradient hydrogel featuring self-floating-induced gradient structures through fast LED light-triggered photopolymerization. A judiciously designed polysiloxane acrylate crosslinker (PA-Si) possesses the self-floating, crosslinking, and initiating properties.

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Atomically precise gold nanoclusters have shown great promise as model electrocatalysts in pivotal electrocatalytic processes such as the hydrogen evolution reaction (HER) and carbon dioxide reduction reaction (CORR). Although the influence of ligands on the electronic properties of these nanoclusters is well acknowledged, the ligand effects on their electrocatalytic performances have been rarely explored. Herein, using [Au(SR)] nanoclusters as a prototype model, we demonstrated the importance of ligand hydrophilicity hydrophobicity in modulating the interface dynamics and electrocatalytic performance.

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Methionine is an amino acid necessary for the growth and development of all animals. Glutathione produced during methionine metabolism can reduce damage to cells caused by oxidative stress. Supplementing restricted amino acids in animals by scientific means will be beneficial to protein synthesis, which will affect the growth and development of animals and will bring huge economic benefits when applied to actual production and life.

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Coagulation factor XIa is a new serine-protease family drug target for next-generation anticoagulants. With the snake venom Kunitz-type peptide BF9 as the scaffold, we obtained a highly active XIa inhibitor BF9-N17K in our previous work, but it also inhibited the hemostatic target plasmin. Here, in order to enhance the selectivity of BF9-N17K toward XIa, four mutants, BF9-N17K-L19A, BF9-N17K-L19S, BF9-N17K-L19D, and BF9-N17K-L19K, were further designed using the P2' amino acid classification scanning strategy.

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Purpose: Intrahepatic cholangiocarcinoma (ICC) is a common primary hepatic tumors with a 5-year survival rate of less than 20%. Therefore, it is crucial to elucidate the molecular mechanisms of ICC. Recently, the advance of high-throughput chromosome conformation capture (Hi-C) technology help us look insight into the three-dimensional (3D) genome structure variation during tumorigenesis.

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The two contradictory entities in nature often follow the principle of unity of opposites, leading to optimal overall performance. Particularly, aggregation-induced emission luminogens (AIEgens) with donor-acceptor (D-A) structures exhibit tunable optical properties and versatile functionalities, offering significant potential to revolutionize cancer treatment. However, trapped by low molar absorptivity (ε) owing to the distorted configurations, the ceilings of their photon-harvesting capability and the corresponding phototheranostic performance still fall short.

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Background: A multivariate predictive model was constructed using baseline and 12-week clinical data to evaluate the rate of clearance of hepatitis B surface antigen (HBsAg) at the 48-week mark in patients diagnosed with chronic hepatitis B who are receiving treatment with pegylated interferon α (PEG-INFα).

Methods: The study cohort comprised CHB patients who received pegylated interferon treatment at Mengchao Hepatobiliary Hospital, Fujian Medical University, between January 2019 and April 2024. Predictor variables were identified (LASSO), followed by multivariate analysis and logistic regression analysis.

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To investigate the characteristics of respiratory-swallow coordination (RSC) in poststroke dysphagia (PSD) patients following infratentorial stroke (IS) and further explore their association with aspiration. PSD patients after IS and age-matched healthy controls were recruited. Nasal airflow and sound signals were recorded using a nasal cannula-type flow sensor and contact microphone, which were synchronized with videofluoroscopic swallowing studies (VFSS).

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Objectives: Imipenem/cilastatin/relebactam (IMI/REL) is a β-lactam/β-lactamase inhibitor combination effective against gram-negative pathogens. Efficacy and safety of IMI/REL were studied in critically ill adults with hospital-acquired bacterial pneumonia (HABP) or ventilator-associated bacterial pneumonia (VABP).

Methods: In this phase III, double-blind, multinational, randomized trial (NCT03583333), adults with HABP/VABP were randomized 1:1 to receive intravenous IMI/REL (500 mg/250 mg) or piperacillin/tazobactam (PIP/TAZ; 4000 mg/500 mg) every 6 h for 7-14 days.

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Article Synopsis
  • * This study introduces Fe-CHC nanoparticles that inhibit the MCT4 transporter to acidify the intracellular environment, leading to higher lethality in tumor cells via enhanced CDT through Fenton reactions.
  • * Experimental results demonstrate that Fe-CHC nanoparticles not only significantly improve anti-tumor effects against glioblastoma but also impede tumor metastasis by reducing lactate and hydrogen levels outside the cells, offering new avenues for tumor treatment.
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  • Hypertension and type 2 diabetes contribute to an increased risk of premature death and related diseases, particularly affecting the same population.
  • An expert consensus using the GRADE approach was formed to create strategies aimed at reducing cardiovascular and kidney-related deaths while minimizing treatment burdens for adults with type 2 diabetes.
  • A multidisciplinary team developed 12 evidence-based recommendations focusing on screening, monitoring, lifestyle changes, and medication for individuals with type 2 diabetes, specifically addressing those who also have hypertension.
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Background: This study investigated the trajectories of interpersonal stress and psychological pain and their effects on self-harm behaviors in adolescents and explored the reciprocal associations between interpersonal stress and NSSI/SA.

Methods: The participants included 1149 adolescents (50.3% women; M = 12.

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  • Recent research suggests that the coagulation system in mammals helps defend against bacterial infections by trapping bacteria in clots and producing antimicrobial peptides.
  • A study identified a new bacterial exotoxin called F6W77, which contains five Kunitz-type domains that have similarities to animal but not plant proteins.
  • Evaluation of these Kunitz-domain peptides revealed that KABP1 and KABP5 effectively inhibit specific coagulation factors, indicating a new mechanism by which bacteria may evade the host's defense system.
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  • The study focuses on Polycystic Ovary Syndrome (PCOS), a common reproductive hormone disorder in women that can lead to a heightened risk of ovarian hyperstimulation syndrome (OHSS) during fertility treatments.
  • It included a retrospective analysis of 200 PCOS patients, with 118 exhibiting a high ovarian response (HOR) and 82 showing a normal response (NOR), revealing significant differences in hormone levels and characteristics between the two groups.
  • Key findings showed that HOR patients had higher levels of anti-Müllerian hormone (AMH) and displayed more oocytes and elevated inflammatory markers during controlled ovarian stimulation, suggesting the involvement of CCL25/CCR9 in high ovarian response.*
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  • Tarperprumig (ALXN1820) is a bispecific antibody designed to treat conditions caused by dysregulated activity in the complement alternative pathway, usable via small volume injections either under the skin or intravenously.
  • It consists of two variable domains that target properdin and human serum albumin, showing a high binding affinity and forming a stable complex.
  • The antibody effectively inhibits key processes related to complement pathway activation and is currently undergoing clinical development for relevant disorders.
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  • Darkness can trigger leaf senescence in rice, yet the genetic factors behind this process are not fully understood.
  • Indica and japonica rice varieties respond differently to dark-induced leaf senescence (DILS), with genome-wide association studies identifying numerous loci crucial for its regulation.
  • A total of 357 candidate genes linked to senescence processes were discovered, highlighting two key genes, OsMYB21 and OsSUB1B, which regulate the onset and progression of DILS, respectively.
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Purpose: Photodynamic therapy (PDT) induces anti-tumor immune responses by triggering immunogenic cell death in tumor cells. Previously, we demonstrated that novel QDs-RGD nanoparticles exhibited high efficiency as photosensitizers in the treatment of pancreatic cancer. However, the underlying mechanism of the anti-tumor immune effects induced by the photosensitizer remains unknown.

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Article Synopsis
  • Thiolate-protected metal nanoclusters (NCs), like PtAu(SCH), are used in electrocatalysis, but their dynamic behavior and the origins of their activity are not well understood.
  • Using advanced calculations and surface-enhanced infrared spectroscopy, researchers discovered that the active site for hydrogen evolution reactions (HER) includes not just the central Pt atom but also exposed Au sites.
  • This study reveals that dethiolated PtAu, which has a unique synergy between Pt and Au, exhibits enhanced HER performance that even outperforms traditional Pt/C catalysts, providing new insights into the catalytic roles of these metal nanoclusters.
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