Upper Gastrointestinal and Cutaneous Varicella in an Adult Male.

In this case report, we presented a unique instance of varicella in a 35-year-old male, characterized by both gastrointestinal and skin involvement. This case highlights the importance of recognizing varicella's atypical manifestations, particularly in adult patients with gastrointestinal symptoms, ensuring prompt diagnosis and appropriate management.

Gut microbiota alterations induced by Roux-en-Y gastric bypass result in glucose-lowering by enhancing intestinal glucose excretion.

Roux-en-Y gastric bypass (RYGB) results in glucose-lowering in patients with type 2 diabetes mellitus (T2DM) and may be associated with increased intestinal glucose excretion. However, the contribution of intestinal glucose excretion to glycemic control after RYGB and its underlying mechanisms are not fully elucidated. Here, we confirmed that intestinal glucose excretion significantly increased in obese rats after RYGB, which was negatively correlated with postoperative blood glucose levels.

2'-FL and cross-feeding bifidobacteria reshaped the gut microbiota of infants with atopic dermatitis ex vivo and prevented dermatitis in mice post-microbiota transplantation through retinol metabolism activation.

2'-Fucosyllactose (2'-FL), a predominant human milk oligosaccharide, plays a crucial role in the development of the infant gut microbiota and immune system. However, the microbiota of infants with atopic dermatitis (AD) often has difficulty utilizing 2'-FL. Here, we found that strains from human milk, FN120 and subsp.

Computational and Experimental Elucidation of the Charge-Dependent Acid-Etching Dynamics and Electrocatalytic Performance of Au(SR) (q = -1, 0, +1) Nanoclusters.

Using thiolate-protected Au(SR) nanocluster (NC) with different charge states as the test candidate, how the charge effect affects the etching dynamics of thiolate ligands in acid and the electrocatalytic performance is explored. The ab initio molecular dynamics (AIMD) simulations revealed the charge-dependent reaction kinetics in acid, where the anionic and neutral Au(SCH) (q = -1, 0) favorably react with the acid and partially remove the thiolate ligands via two-step proton attack, while the cationic Au(SCH) NC is acid-resistant with no tendency for -SR removal. Density functional theory (DFT) calculations further predict that the dethiolated Au sites exhibit enhanced catalytic activity for CO electroreduction to CO, with the anionic Au showing significantly superior activity.

A Prestressed Concrete Cylinder Pipe Broken Wire Detection Algorithm Based on Improved YOLOv5.

The failure accidents of prestressed concrete cylinder pipe (PCCP) seriously affect the economic feasibility of the construction site. The traditional method of needing to stop construction for pipe inspection is time-consuming and laborious. This paper studies the PCCP broken wire identification algorithm based on deep learning.

A systematic review of reported symptomatic Elizabethkingia infection cases in children and adults.

Background: Elizabethkingia infections are caused by the species Elizabethkingia, which recently has become important as a cause of serious infection among neonates and immunocompromised adults. The systematic review summarized clinical data on symptomatic infections caused by Elizabethkingia, including species identification, patient outcomes, and therapeutic approaches.

Methods: The PRISMA guidelines were followed in conducting the systematic review.

Drug-induced nasal septum perforation: a disproportionality analysis of the FDA adverse event reporting system database.

Background: Nasal septum perforation represents a significant clinical concern, with limited investigations into the role of medications in its etiology. This study utilizes the FDA Adverse Event Reporting System (FAERS) database to identify the drugs associated with nasal septum perforation and assess their risk.

Research Design And Methods: This retrospective pharmacovigilance study analyzed drug-induced nasal septum perforation data from January 2004 to December 2023.

Construction of near-infrared gradient hydrogel actuators using self-floating induction and LED photopolymerization.

Creating gradient hydrogels for remote control of bionic systems continues to be challenging due to the complexity of the preparation process. Herein, we have proposed a strategy to prepare near-infrared photothermal conversion gradient hydrogel featuring self-floating-induced gradient structures through fast LED light-triggered photopolymerization. A judiciously designed polysiloxane acrylate crosslinker (PA-Si) possesses the self-floating, crosslinking, and initiating properties.

Ligand-induced changes in the electrocatalytic activity of atomically precise Au nanoclusters.

Atomically precise gold nanoclusters have shown great promise as model electrocatalysts in pivotal electrocatalytic processes such as the hydrogen evolution reaction (HER) and carbon dioxide reduction reaction (CORR). Although the influence of ligands on the electronic properties of these nanoclusters is well acknowledged, the ligand effects on their electrocatalytic performances have been rarely explored. Herein, using [Au(SR)] nanoclusters as a prototype model, we demonstrated the importance of ligand hydrophilicity hydrophobicity in modulating the interface dynamics and electrocatalytic performance.

Identification of RNA Editing Sites Reveals Functional Modifications with the Addition of Methionine to the Daily Rations of Yaks.

Methionine is an amino acid necessary for the growth and development of all animals. Glutathione produced during methionine metabolism can reduce damage to cells caused by oxidative stress. Supplementing restricted amino acids in animals by scientific means will be beneficial to protein synthesis, which will affect the growth and development of animals and will bring huge economic benefits when applied to actual production and life.

Improvement in XIa Selectivity of Snake Venom Peptide Analogue BF9-N17K Using P2' Amino Acid Replacements.

Coagulation factor XIa is a new serine-protease family drug target for next-generation anticoagulants. With the snake venom Kunitz-type peptide BF9 as the scaffold, we obtained a highly active XIa inhibitor BF9-N17K in our previous work, but it also inhibited the hemostatic target plasmin. Here, in order to enhance the selectivity of BF9-N17K toward XIa, four mutants, BF9-N17K-L19A, BF9-N17K-L19S, BF9-N17K-L19D, and BF9-N17K-L19K, were further designed using the P2' amino acid classification scanning strategy.

Three-dimensional genome architecture in intrahepatic cholangiocarcinoma.

Purpose: Intrahepatic cholangiocarcinoma (ICC) is a common primary hepatic tumors with a 5-year survival rate of less than 20%. Therefore, it is crucial to elucidate the molecular mechanisms of ICC. Recently, the advance of high-throughput chromosome conformation capture (Hi-C) technology help us look insight into the three-dimensional (3D) genome structure variation during tumorigenesis.

Integration of Motion and Stillness: A Paradigm Shift in Constructing Nearly Planar NIR-II AIEgen with Ultrahigh Molar Absorptivity and Photothermal Effect for Multimodal Phototheranostics.

The two contradictory entities in nature often follow the principle of unity of opposites, leading to optimal overall performance. Particularly, aggregation-induced emission luminogens (AIEgens) with donor-acceptor (D-A) structures exhibit tunable optical properties and versatile functionalities, offering significant potential to revolutionize cancer treatment. However, trapped by low molar absorptivity (ε) owing to the distorted configurations, the ceilings of their photon-harvesting capability and the corresponding phototheranostic performance still fall short.

A predictive model for functional cure in chronic HBV patients treated with pegylated interferon alpha: a comparative study of multiple algorithms based on clinical data.

Background: A multivariate predictive model was constructed using baseline and 12-week clinical data to evaluate the rate of clearance of hepatitis B surface antigen (HBsAg) at the 48-week mark in patients diagnosed with chronic hepatitis B who are receiving treatment with pegylated interferon α (PEG-INFα).

Methods: The study cohort comprised CHB patients who received pegylated interferon treatment at Mengchao Hepatobiliary Hospital, Fujian Medical University, between January 2019 and April 2024. Predictor variables were identified (LASSO), followed by multivariate analysis and logistic regression analysis.

The Respiratory-Swallow Coordination may be Related to Aspiration in Infratentorial Stroke Patients.

To investigate the characteristics of respiratory-swallow coordination (RSC) in poststroke dysphagia (PSD) patients following infratentorial stroke (IS) and further explore their association with aspiration. PSD patients after IS and age-matched healthy controls were recruited. Nasal airflow and sound signals were recorded using a nasal cannula-type flow sensor and contact microphone, which were synchronized with videofluoroscopic swallowing studies (VFSS).

A phase III, randomized, controlled noninferiority trial to study the efficacy and safety of imipenem/cilastatin/relebactam (IMI/REL) vs piperacillin/tazobactam (PIP/TAZ) in patients with hospital-acquired bacterial pneumonia (HABP) or ventilator-associated bacterial pneumonia (VABP).

Objectives: Imipenem/cilastatin/relebactam (IMI/REL) is a β-lactam/β-lactamase inhibitor combination effective against gram-negative pathogens. Efficacy and safety of IMI/REL were studied in critically ill adults with hospital-acquired bacterial pneumonia (HABP) or ventilator-associated bacterial pneumonia (VABP).

Methods: In this phase III, double-blind, multinational, randomized trial (NCT03583333), adults with HABP/VABP were randomized 1:1 to receive intravenous IMI/REL (500 mg/250 mg) or piperacillin/tazobactam (PIP/TAZ; 4000 mg/500 mg) every 6 h for 7-14 days.

Developmental trajectories of interpersonal stress in school and psychological pain contributing to self-harm in adolescents.

Background: This study investigated the trajectories of interpersonal stress and psychological pain and their effects on self-harm behaviors in adolescents and explored the reciprocal associations between interpersonal stress and NSSI/SA.

Methods: The participants included 1149 adolescents (50.3% women; M = 12.

Photodynamic Therapy Using RGD-Functionalized Quantum Dots Elicit a Potent Immune Response in a Syngeneic Mouse Model of Pancreatic Cancer.

Purpose: Photodynamic therapy (PDT) induces anti-tumor immune responses by triggering immunogenic cell death in tumor cells. Previously, we demonstrated that novel QDs-RGD nanoparticles exhibited high efficiency as photosensitizers in the treatment of pancreatic cancer. However, the underlying mechanism of the anti-tumor immune effects induced by the photosensitizer remains unknown.