Dissipation and residue analysis of novel nematicide trifluorocide in ginseng and soil using modified QuEChERS method coupled with HPLC-MS/MS.

In the present study, an analytical method that combined a modified QuEChERS (quick, easy, cheap, effective, rugged, and safe) method and high-performance liquid chromatography coupled with tandem mass spectrometry was developed to determine trifluorocide in fresh and dried ginseng roots, plants (stems and leaves), and soil. At three spiked levels (0.01, 0.

DNAzyme-Amplified Label-Free Biosensor for the Simple and Sensitive Detection of Pyrophosphatase.

The level of pyrophosphatase (PPase) expression has been suggested as a potential biomarker of various cancers, and its prognostic value has been evaluated in patients suffering from lung cancer, colorectal cancer, and hyperthyroidism. However, the detection of PPase usually needs specific materials that require complicated, time-consuming reactions with restricted linear range and sensitivity, limiting their application in early clinical diagnosis. Herein, we developed a DNAzyme-based biosensor for the detection of PPase.

Uniform H-CdS@NiCoP core-shell nanosphere for highly efficient visible-light-driven photocatalytic H evolution.

Constructing highly efficient and cost-effective photocatalyst system has been a big challenge for photocatalysis. Herein, CdS nanosphere (N-CdS), hollow CdS (H-CdS) and a series of H-CdS@NiCoP core-shell nanospheres have been successfully prepared via a facile hydrothermal method. The activity test showed that H-CdS exhibited higher photocatalytic activity (3.

Novel Dyadic Amorphous-Crystalline Nano-Titania Hybrids for Sacrifiers-Stored Photocatalysis.

Sacrifiers-promoted photocatalysis is a useful way to achieve high efficiency photoreduction and photocatalytic hydrogen production for photocatalysts of weak reductive power such as TiO. Herein we report a new method to fabricate a unique dyadic hybrid consisting of closely compacted crystalline (anatase) and titanium glycerolate (TiG)-derived organic group-retained amorphous nanoparticles to validate adsorption-stored sacrifiers-promoted photocatalysis instead of using sacrifiers in bulk solution. It was found that ascorbic acid (AA)-modified TiG prepared at a small fraction of glycerol, characterized by peculiar cocoon/open nanocontainer-type morphologies, varieties of oxygen containing groups, and remarkably high specific surface area, is suitable for precursing such hybrids.

Extracellular calcium alters calcium-sensing receptor network integrating intracellular calcium-signaling and related key pathway.

G-protein-coupled receptors (GPCRs) are a target for over 34% of current drugs. The calcium-sensing receptor (CaSR), a family C GPCR, regulates systemic calcium (Ca) homeostasis that is critical for many physiological, calciotropical, and noncalciotropical outcomes in multiple organs. However, the mechanisms by which extracellular Ca (Ca) and the CaSR mediate networks of intracellular Ca-signaling and players involved throughout the life cycle of CaSR are largely unknown.

HybridCTrm: Bridging CNN and Transformer for Multimodal Brain Image Segmentation.

Multimodal medical image segmentation is always a critical problem in medical image segmentation. Traditional deep learning methods utilize fully CNNs for encoding given images, thus leading to deficiency of long-range dependencies and bad generalization performance. Recently, a sequence of Transformer-based methodologies emerges in the field of image processing, which brings great generalization and performance in various tasks.

Cold shock protein 3 plays a negative role in apple drought tolerance by regulating oxidative stress response.

As RNA chaperones, cold shock proteins (CSPs) are essential for cold adaptation. Although the functions of CSPs in cold response have been demonstrated in several species, the roles of CSPs in response to drought are largely unknown. Here, we demonstrated that MdCSP3, a downstream target gene of MdMYB88 and MdMYB124, contributes to drought tolerance in apple (Malus × domestica).

NtMYB305a binds to the jasmonate-responsive GAG region of NtPMT1a promoter to regulate nicotine biosynthesis.

MYB transcription factors play essential roles in regulating plant secondary metabolism and jasmonate (JA) signaling. Putrescine N-methyltransferase is a key JA-regulated step in the biosynthesis of nicotine, an alkaloidal compound highly accumulated in Nicotiana spp. Here we report the identification of NtMYB305a in tobacco (Nicotiana tabacum) as a regulatory component of nicotine biosynthesis and demonstrate that it binds to the JA-responsive GAG region, which comprises a G-box, an AT-rich motif, and a GCC-box-like element, in the NtPMT1a promoter.

Single-molecule photocatalytic dynamics at individual defects in two-dimensional layered materials.

The insightful comprehension of in situ catalytic dynamics at individual structural defects of two-dimensional (2D) layered material, which is crucial for the design of high-performance catalysts via defect engineering, is still missing. Here, we resolved single-molecule trajectories resulted from photocatalytic activities at individual structural features (i.e.

Comparison of the accuracy of measuring blood glucose in whole blood of arteriovenous mixed blood by two kinds of blood glucose meters.

Background: Portable blood glucose meters are the main method for detecting the blood glucose status of clinical patients.

Objective: To investigate the accuracy of detecting blood glucose in haemodialysis patients by sampling two blood glucose meters through the haemodialysis line.

Methods: Convenient sampling was used to select 80 patients with maintenance haemodialysis.

Scalable 3D printing of aperiodic cellular structures by rotational stacking of integral image formation.

The limitation of projection microstereolithography in additive manufacturing methods is that they typically use a single-aperture imaging configuration, which restricts their ability to produce microstructures in large volumes owing to the trade-off between image resolution and image field area. Here, we propose an integral lithography based on integral image reconstruction coupled with a planar lens array. The individual microlenses maintain a high numerical aperture and are used to create digital light patterns that can expand the printable area by the number of microlenses (10 to 10), thereby allowing for the scalable stereolithographic fabrication of 3D features that surpass the resolution-to-area scaling limit.

Effect of anti-diabetic drugs in dialysis patients with diabetes: a nationwide retrospective cohort study.

Background: Type 2 diabetes mellitus is common in patients undergoing dialysis. However, the association between anti-diabetic drug use and survival outcomes is rarely discussed. We aimed to investigate whether continued anti-diabetic medication use affects the survival of diabetic dialysis patients and whether different hypoglycemic drug use influences prognosis.

High resolution stereolithography fabrication of perfusable scaffolds to enable long-term meso-scale hepatic culture for disease modeling.

Microphysiological systems (MPS), comprising human cell cultured in formats that capture features of the three-dimensional (3D) microenvironments of native human organs under microperfusion, are promising tools for biomedical research. Here we report the development of a mesoscale physiological system (MePS) enabling the long-term 3D perfused culture of primary human hepatocytes at scales of over 10cells per MPS. A central feature of the MePS, which employs a commercially-available multiwell bioreactor for perfusion, is a novel scaffold comprising a dense network of nano- and micro-porous polymer channels, designed to provide appropriate convective and diffusive mass transfer of oxygen and other nutrients while maintaining physiological values of shear stress.

Three-Dimensional Soundproof Acoustic Metacage.

In this Letter, we theoretically propose and experimentally demonstrate a three-dimensional soundproof acoustic cage structure, hereby denoted as an acoustic metacage. The metacage is composed of six acoustic metamaterial slabs with open holes and hidden bypass space coiling tunnels connected to the holes. Band structure analysis reveals a novel physical mechanism to open a low-frequency broad partial band gap via the band folding in other directions, which can also be interpreted by an effective medium with indefinite effective mass density and negative effective modulus.

B-type natriuretic peptide levels and volume status in twice-weekly hemodialysis patients.

Background: Twice-weekly hemodialysis (HD) could be regarded as an important part of incremental hemodialysis, volume status of this treatment model remains to be elucidated.

Methods: Patients undergoing regular twice-weekly or thrice-weekly hemodialysis in our unit on June 2015 were enrolled into the cohort study with an average of 2.02 years follow-up.

Design, synthesis, and pharmacological evaluation of sinomenine derivatives on rings A and C: Novel compounds screening for aplastic anemia targeting on cytotoxic T lymphocyte.

Cytotoxic T lymphocyte (CTL), a key effector cell in aplastic anemia (AA) immune injury, is shown to be a potential target for AA drug therapy. However, there is no candidate for this target till now. Oriented by the inhibition activity of CTL and macrophage derived nitric oxide (NO), a series of novel sinomenine derivatives on rings A and C are designed, synthesized and screened.

Tuning Protein Dynamics to Sense Rapid Endoplasmic-Reticulum Calcium Dynamics.

Multi-scale calcium (Ca ) dynamics, exhibiting wide-ranging temporal kinetics, constitutes a ubiquitous mode of signal transduction. We report a novel endoplasmic-reticulum (ER)-targeted Ca indicator, R-CatchER, which showed superior kinetics in vitro (k ≥2×10  s , k ≥7×10  M  s ) and in multiple cell types. R-CatchER captured spatiotemporal ER Ca dynamics in neurons and hotspots at dendritic branchpoints, enabled the first report of ER Ca oscillations mediated by calcium sensing receptors (CaSRs), and revealed ER Ca -based functional cooperativity of CaSR.

Rapid Determination of 21 Chinese Domestically Registered Pesticides in Ginseng Using Cleanup Based on Zirconium-Oxide-Modified Silica and Ultrahigh-Performance Liquid Chromatography-Tandem Mass Spectrometry.

In this study, an analytical method was developed for the rapid determination of 21 pesticides used in ginseng cultivation. All pesticides covered by this method have been registered by 2020 in China for use on ginseng. The extracts were cleaned up using zirconium-oxide-modified silica (Z-Sep) and primary secondary amine (PSA).

Variations of heavy metals, nutrients, POPs and particle size distribution during "sludge anaerobic digestion-solar drying-land utilization process": Case study in China.

Sewage sludge was rich in pollutants such as heavy metals, nutrients and persistent organic pollutants. Anaerobic digestion can effectively degrade the pollutants while achieving sludge stabilization and reduction. This study took a sludge treatment plant located in Anhui Province, China as a case study, investigating the variations of multiple substances and particle size distribution during sludge anaerobic digestion-solar drying-land utilization process.

Comparing N-acetylcysteine with sodium thiosulfate for relieving symptoms caused by Lugol's iodine chromoendoscopy: a randomized, double-blind trial.

Background And Aims: Lugol's iodine chromoendoscopy is an important method to detect esophageal squamous cell carcinoma. Sodium thiosulfate solution (STS) has been used to neutralize iodine after Lugol's chromoendoscopy; however, it is not available in many medical centers. The aim of the current study was to assess the efficacy of N-acetylcysteine solution (NAC) for relieving symptoms caused by Lugol's iodine chromoendoscopy.

Skin-electrode iontronic interface for mechanosensing.

Electrodermal devices that capture the physiological response of skin are crucial for monitoring vital signals, but they often require convoluted layered designs with either electronic or ionic active materials relying on complicated synthesis procedures, encapsulation, and packaging techniques. Here, we report that the ionic transport in living systems can provide a simple mode of iontronic sensing and bypass the need of artificial ionic materials. A simple skin-electrode mechanosensing structure (SEMS) is constructed, exhibiting high pressure-resolution and spatial-resolution, being capable of feeling touch and detecting weak physiological signals such as fingertip pulse under different skin humidity.

Microstructured Surfaces for Reducing Chances of Fomite Transmission via Virus-Containing Respiratory Droplets.

Evaporation-induced particle aggregation in drying droplets is of significant importance in the prevention of pathogen transfer due to the possibility of indirect fomite transmission of the infectious virus particles. In this study, particle aggregation was directionally controlled using contact line dynamics (pinned or slipping) and geometrical gradients on microstructured surfaces by the systematic investigation of the evaporation process on sessile droplets and sprayed microdroplets laden with virus-simulant nanoparticles. Using this mechanism, we designed robust particle capture surfaces by significantly inhibiting the contact transfer of particles from fomite surfaces.

Toward broader applications of iron ore waste in pollution control: Adsorption of norfloxacin.

Norfloxacin, a kind of antibiotic frequently detected in environments, represents a group of non-persistent organic pollutants with latent risks to the ecosystem. Iron ore waste, generated and accumulated in large quantities from the iron/steel industry, was evaluated as a potential sorbent for norfloxacin removal. Kinetics analysis showed that the adsorption process reached equilibrium at 72 h, and the adsorption process could be best defined by the pseudo-second-order kinetics with the primary mechanism of norfloxacin adsorption suggested to be cation exchange.

Characterizing ammonia emissions from water bodies using dynamic floating chambers.

Ammonia (NH) is the most important alkaline gas in the atmosphere and plays a central role in atmospheric pollution and the global N cycle. Water bodies receive increasing nitrogen inputs from effluents and atmospheric deposition due to anthropogenic activities and are regarded as the major natural NH and NH sinks. In this work, floating dynamic flux chambers were deployed at four types of freshwater (rivers, large reservoirs, medium-sized reservoirs and ponds) systems and a coastal seawater system to estimate the water-air NH emission fluxes.