The current situation and associated factors of preoperative frailty in elderly patients undergoing abdominal surgery.

Background: This study aimed to investigate the current preoperative frailty status of elderly patients undergoing abdominal surgery and identify its associated factors. The objective of this study was to provide clinicians with valuable insights for implementing frailty intervention strategies.

Methods: A cross-sectional study was conducted with 375 elderly patients who underwent abdominal surgery at a tertiary hospital in Chengdu, Sichuan Province, between October 2021 and August 2022.

Clinicopathological Features of Epstein-Barr Virus-Positive Neuroendocrine Carcinoma: Analysis of Twenty-Two Cases.

Epstein-Barr Virus (EBV)-positive neuroendocrine carcinoma (NEC) is a rare neoplasm with limited histopathological and therapeutic data. This report presents 22 cases of EBV-positive NEC, analyzing age distribution, morphology, and immunophenotype. The median patient age was 47 years (range: 27-67 years), with a male-to-female ratio of 17:5.

Health emergency preparedness behavior and its influencing factors among elderly people in the community of Qiqihar.

Objective: To facilitate targeted interventions for elderly individuals, we investigated the current status of health emergency preparedness behavior of elderly people in the community of China Qiqihar and analyzed its influencing factors.

Methods: From October 2019 to January 2020, 700 elderly people living in Qiqihar, were selected by a stratified quota sampling method for face-to-face investigation. The research tool was the Questionnaire on Health Emergency Preparedness Level of the old people in the Community, which was revised based on previous studies.

Effect of a systemic intervention combined with a psychological intervention in stroke patients with oropharyngeal dysfunction.

Background: Stroke frequently results in oropharyngeal dysfunction (OD), leading to difficulties in swallowing and eating, as well as triggering negative emotions, malnutrition, and aspiration pneumonia, which can be detrimental to patients. However, routine nursing interventions often fail to address these issues adequately. Systemic and psychological interventions can improve dysphagia symptoms, relieve negative emotions, and improve quality of life.

Ruthenium and Iron Co-doped Molybdenum Carbide as a Stable Hydrogen Evolution Electrocatalyst in Harsh Electrolyte.

Electrocatalytic water splitting is one of the most commercially valuable pathways of hydrogen production especially combined with renewable electricity; however, efficient and durable electrocatalysts are urgently needed to reduce electric energy consumption. Here, we reported a Ru and Fe co-doped Mo C on nitrogen doped carbon via a controllable two-step method, which can be used for efficient and enduring hydrogen evolution reaction. At 10, 100 and 200 mA cm in acidic electrolyte, the resultant Ru-Fe/Mo C@NC delivered low overpotentials of 31, 78 and 103 mV, respectively, which are comparable to that of the commercial Pt/C (20 wt %).

Eukaryotic initiation factor 3b regulates the development and progression of breast cancer.

The tumorigenesis of breast cancer is a complex process involving multiple factors, among which abnormal gene expression is a key event. Nevertheless, studies on the regulation of gene expression have focused primarily on the transcriptional level, although the abnormal translation regulation is also closely related to tumorigenesis. Accumulating evidence has indicated the dysregulation of eukaryotic initiation factor (eIF) subunits in a variety of tumors, which contributes to the malignant transformation, tumor growth, metastasis, and the prognosis of patients.

Impact of extended nursing model after multi-disciplinary treatment on young patient with post-stroke.

Background: Stroke has become one of the most serious life-threatening diseases due to its high morbidity, disability, recurrence and mortality rates.

Aim: To explore the intervention effect of multi-disciplinary treatment (MDT) extended nursing model on negative emotions and quality of life of young patients with post-stroke.

Methods: A total of 60 young stroke patients who were hospitalized in the neurology department of our hospital from January 2020 to December 2021 were selected and randomly divided into a control group and an experimental group, with 30 patients in each group.

Testicular injury during SARS-CoV-2 infection may be neglected: An assessment from scRNA-seq profiling and protein detection of angiotensin-converting enzyme II.

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is outbreaking globally. SARS-CoV-2 invades host cells via angiotensin-converting enzyme II (ACE2) and causes multiple-organ injury. Autopsy studies indicated that the testis of patients with COVID-19 exhibited various degrees of spermatogenic cell reduction and injury, but the composition of ACE2-expressing cells and their proportion in the testes have remained to be determined.

Carbon reduction potential and cost evaluation of different mitigation approaches in China's coal to olefin Industry.

Coal-based olefin (CTO) industry as a complement of traditional petrochemical industry plays vital role in China's national economic development. However, high CO emission in CTO industry is one of the fatal problems to hinder its development. In this work, the carbon emission and mitigation potentials by different reduction pathways are evaluated.

hsa_circ_0006459 and hsa_circ_0015962 affect prognosis of Dengue fever.

Circular ribonucleic acids (circRNAs) are widely expressed in human cells and play an important role in the pathogenesis of many diseases. Some circRNAs have microRNA (miRNA) binding response elements and interact with miRNA to regulate the expression of target genes.Four patients with a preliminary diagnosis of dengue fever (DF), peripheral whole blood sample in anticoagulant was collected before treatment (pretreatment group) and after effective treatment (posttreatment group), and eight samples were separated and used to screen differentially expressed circRNAs with microarray analysis.

Leucandioxoles A and B, two 1,3-benzodioxole derivatives from the South China Sea sponge sp.

Two new 1,3-benzodioxole derivatives, leucandioxoles A and B (-), together with two known related compounds (-), have been isolated from the South China Sea sponge sp. The structures of all compounds were clearly elucidated on the basis of spectroscopic analyses and compared with the literatures. The cytotoxicity against A549, Hep G2, MDA-MB-231, and HeLa cell lines of - were evaluated.

Jumonji domain containing 5 is a potential prognostic indicator in non-small cell lung cancer patients who received platinum-based chemotherapy.

Background: Platinum-based chemotherapy is the cornerstone of non-small cell lung cancer (NSCLC) therapy. However, the molecular mechanisms and predictive markers of platinum chemoresistance have not been fully understood. Our recent study revealed that Jumonji domain containing 5 (JMJD5) expression in cells was elevated under DNA damage by alkylating agent or UV radiation, which suggests a potential role of JMJD5 in DNA damage related chemoresistance.

Facile and Rapid Preparation of Ag@ZIF-8 for Carboxylation of Terminal Alkynes with CO in Mild Conditions.

Metal-organic frameworks (MOFs) are promising hosts for catalytic active sites due to their adjustable porosity and framework chemistry. Strategies to improve synergistic effects between the installed sites and the parent MOF are highly desired. Herein, a facile and rapid method for the preparation of Ag@ZIF-8 materials was reported.

[Spatiotemporal dynamic simulation on aboveground carbon storage of bamboo forest and its influence factors in Zhejiang Province, China.].

Bamboo forests have an efficient carbon sequestration capacity and play an important role in responding to global climate change. However, the current estimation of bamboo carbon storage has some errors, leading to uncertainty in the spatiotemporal pattern of bamboo forest carbon storage. This study simulated aboveground carbon storage of Zhejiang Province, China, during 1984-2014 based on the combination of an improved BIOME-BGC (biogeochemical cycles) model and remote sensing data, with the accuracy being verified with forest resource inventory data.

Rationally designed pure-inorganic upconversion nanoprobes for ultra-highly selective hydrogen sulfide imaging and elimination .

Lung injury is a hydrogen sulfide (HS)-associated complication with high mortality in acute pancreatitis (AP) cases. Herein, we used Prussian Blue (PB) as a HS-responsive acceptor to develop a novel pure-inorganic upconversion nanoprobe for detecting and eliminating HS, which can be used for diagnosing AP and alleviating lung injury. Upconversion nanoprobes with 5 nm PB shells were optimized to achieve outstanding HS detection capacity (linear range: 0-150 μM, LOD: 50 nM), which met the serum HS range, and thus were feasible for imaging HS .

Biocompatible Heat-Shock Protein Inhibitor-Delivered Flowerlike Short-Wave Infrared Nanoprobe for Mild Temperature-Driven Highly Efficient Tumor Ablation.

Multifunctional nanomaterials for dual-mode imaging guided cancer therapy are highly desirable in clinical applications. Herein, a flowerlike NiS-coated NaLuF:Nd (Lu:Nd@NiS) nanoparticle was synthesized as a novel therapeutic agent for short-wave infrared light imaging and magnetic resonance imaging to guide photothermal therapy (PTT). The material was then loaded with phenolic epigallocatechin 3-gallate (EGCG), which is a natural heat-shock protein 90 (HSP90) inhibitor.

Abrogation of cathepsin C by Helicobacter pylori impairs neutrophil activation to promote gastric infection.

Cathepsin C (CtsC) functions as a central coordinator for activation of many serine proteases in immune cells. However, CtsC expression in gastric epithelial cells and its role in Helicobacter pylori infection remain unclear. Real-time PCR, Western blot, and immunohistochemistry analyses identified that CtsC was decreased in gastric mucosa of H.

Green synthesis of ultra-small VO nanodots for acidic-activated HSP60 inhibition and therapeutic enhancement.

Using metal oxide semiconductor nanomaterials for synergistic cancer treatment has recently attracted the attention of numerous researchers. Herein, oxygen-defective vanadium oxide nanodots (VO NDs) with ultra-small size and great dispersibility were synthesized via a novel user-friendly method, and then doxorubicin was loaded onto the VO NDs surfaces. The VO NDs had great photothermal conversion efficiency and stability.

Modeling capillary fringe effect on petroleum vapor intrusion from groundwater contamination.

At contaminated sites, indoor inhalation of volatile organic compounds from groundwater contamination, known as vapor intrusion (VI), is an important exposure pathway to determine groundwater cleanup level. Based on empirical analysis, US EPA concluded that there is a low probability for vapors from fuel hydrocarbons dissolved in groundwater to induce indoor concentrations that exceed risk-based standards, and recommended 6 feet vertical building-source separation distance as the risk screening tool for such cases. In this study, we examine this recommendation by performing numerical modeling to investigate the detailed effects of the capillary fringe on petroleum vapor biodegradation and attenuation.

Investigating the Role of Soil Texture in Petroleum Vapor Intrusion.

In this work we investigate the role of soil texture in petroleum vapor intrusion (PVI) by performing numerical modeling, analytical calculations, and statistical analysis of the USEPA's PVI database. Numerical simulations were conducted for three kinds of soil (sand, sandy loam, and clay), and the results indicate that the maximum attenuations of vapor concentrations from source to indoor air were observed when the clay soil is below the building. In the anaerobic zone, the normalized soil gas concentration profiles were observed to be similar and independent of soil type, whereas in the aerobic zone, a more significant attenuation was observed in finer grained soils.

Examining the role of sub-foundation soil texture in chlorinated vapor intrusion from groundwater sources with a two-layer numerical model.

In this study we investigate the role of the sub-foundation soil texture in determining groundwater source-to-indoor air attenuation factors. A three-dimensional numerical model was used to simulate a series of two-layer scenarios, involving different sub-foundation and deep soil textures, foundation types and groundwater source depths. The results indicate that if the sub-foundation soil permeability is larger than 10 m, the convection dominates the soil gas transport into the building, and the indoor air concentration increases by half an order of magnitude with one order of magnitude increase of the sub-foundation soil permeability.

[Retrieval of leaf area index of Phyllostachys praecox forest based on MODIS reflectance time series data.].

Based on the MODIS surface reflectance data, five vegetation indices, including norma-lized difference vegetation index (NDVI), simple ratio index (SR), Gitelson green index (GI), enhanced vegetation index (EVI) and soil adjusted vegetation index (SAVI) were constructed as remote sensing variables, coupled with the seven original spectral reflectance bands of MODIS. Stepwise regression and correlation analysis were used to select the variables, and the stepwise regression and Back Propagation (BP) neural network models were constructed based on the measured LAI to retrieve the LAI time series data of Phyllostachys praecox (Lei bamboo) forest during the period from January 2014 to March 2017. The retrieval results were compared with MOD15A2 LAI products during the same period.

[RS estimation of inventory parameters and carbon storage of moso bamboo forest based on synergistic use of object-based image analysis and decision tree].

By synergistically using the object-based image analysis (OBIA) and the classification and regression tree (CART) methods, the distribution information, the indexes (including diameter at breast, tree height, and crown closure), and the aboveground carbon storage (AGC) of moso bamboo forest in Shanchuan Town, Anji County, Zhejiang Province were investigated. The results showed that the moso bamboo forest could be accurately delineated by integrating the multi-scale ima ge segmentation in OBIA technique and CART, which connected the image objects at various scales, with a pretty good producer's accuracy of 89.1%.

Artemisinin-Loaded Mesoporous Nanoplatform for pH-Responsive Radical Generation Synergistic Tumor Theranostics.

The development of novel and effective cancer treatments will greatly contribute to prolonging and improving patient lives. In this study, a multifunctional nanoplatform was designed and developed based on mesoporous NiO (mNiO) nanoparticles and terbium complexes as an artemisinin (ART) vehicle, a T-weighted contrast agent, and a luminescence imaging probe. mNiO is a novel pH-responsive material that can degrade and release nickel ions (Ni) in an acidic tumor microenvironment.

Three-Dimensional Simulation of Land Drains as a Preferential Pathway for Vapor Intrusion into Buildings.

Preferential pathways can be significant vapor intrusion (VI) contributors, causing potentially higher inhalation risk to residents of affected buildings than that arising through traditional intrusion pathways. To assess land drains as a preferential pathway, a three-dimensional model, validated using data from a 4-yr field study, was used to study the roles of subfoundation soil permeability on soil gas flow and indoor depressurization. Results indicated that it is almost impossible for an indirect preferential pathway like a land drain ending in subfoundation soils with a permeability <10 m to affect indoor air quality if the land drain connects to a source with the same vapor concentration as that of the groundwater source beneath the building.