A Comprehensive Analysis In Silico of Genes in Maize Revealed Their Potential Role in Response to Abiotic Stress.

β-ketoacyl-CoA synthase (KCS) enzymes play a pivotal role in plants by catalyzing the first step of very long-chain fatty acid (VLCFA) biosynthesis. This process is crucial for plant development and stress responses. However, the understanding of genes in maize remains limited.

Effectiveness of nursing care for cervical cancer patients undergoing chemotherapy: Systematic review and meta-analysis.

Nursing interventions play a critical role in enhancing the quality of life (QoL) and therapeutic outcomes for cervical cancer patients undergoing chemotherapy. However, variations in nursing interventions and patient results require a meta-analysis to consolidate evidence on the most effective nursing approaches. This meta-analysis assessed how nursing care interventions influence QoL, adherence to chemotherapy, and the management of symptoms in cervical cancer patients.

Discovery and characterization of stereodefined PMO-gapmers targeting tau.

Antisense oligonucleotides (ASOs) are an important class of therapeutics to treat genetic diseases, and expansion of this modality to neurodegenerative disorders has been an active area of research. To realize chronic administration of ASO therapeutics to treat neurodegenerative diseases, new chemical modifications that improve activity and safety profiles are still needed. Furthermore, it is highly desirable to develop a single stereopure ASO with a defined activity and safety profile to avoid any efficacy and safety concerns due to the batch-to-batch variation in the composition of diastereomers.

Effect of intravenous urokinase vs best medicine treatment on functional outcome for patients with acute minor stroke (TRUST): a randomized controlled trial.

Background: The benefits of intravenous thrombolysis in patients with acute minor stroke remain controversial. For the aim of providing a better therapeutic strategy, high-quality trials are required to validate the efficacy of thrombolytic medicine other than intravenous recombinant tissue plasminogen and tenecteplase. In the trial, we evaluate the efficacy and safety of urokinase (UK) in acute minor stroke.

C4d immunostaining facilitates differentiation of pemphigoid nodularis from prurigo nodularis.

Pemphigoid nodularis and prurigo nodularis have similar clinicopathological features and are difficult to distinguish. Enzyme-linked immunosorbent assays (ELISA) and direct/indirect immunofluorescence can support the diagnosis of pemphigoid nodularis, but sometimes show contradictory results or are unavailable. We aimed to develop a practical method for differentiating between pemphigoid nodularis and prurigo nodularis.

A new diminutive species of bohaiornithid enantiornithine (Aves: Ornithothoraces) from the Lower Cretaceous Jehol Group, northern China.

Enantiornithes are the most successful early-diverging avian clade, their fossils revealing important information regarding the structure of Cretaceous avifaunas and the parallel refinement of flight alongside the ornithuromorph lineage that includes modern birds. The most diverse recognized family of Early Cretaceous enantiornithines is the Bohaiornithidae, known from the Jehol Biota in northeastern China. Members of this clade enhance our understanding of intraclade morphological diversity and elucidate the independent evolution of this unique lineage.

Metalloprotease inhibitors regulate biliary progenitor cells through sDLK1 in organoid models of liver injury.

Understanding cell fate regulation in the liver is necessary to advance cell therapies for hepatic disease. Liver progenitor cells (LPC) contribute to tissue regeneration after severe hepatic injury yet signals instructing progenitor cell dynamics and fate are largely unknown. The Tissue Inhibitor of Metalloproteinases, TIMP1 and TIMP3 control the sheddases ADAM10 and ADAM17, key for NOTCH activation.

Therapeutic effectiveness and safety profile of lanthanum carbonate in conjunction with calcium carbonate for managing hyperphosphatemia in hemodialysis patients: a meta-analysis of randomized controlled trials.

Objective: To comprehensively investigate the efficacy and safety of lanthanum carbonate in conjugation with calcium carbonate combination in hemodialysis patients with hyperphosphatemia via a meta-analysis of randomized controlled trials (RCTs).

Method: We conducted a literature search in databases of PubMed, Embase, and Web of Science for RCTs investigating the effect of lanthanum carbonate in combination with calcium carbonate for treating hyperphosphatemia in hemodialysis patients. The search covered all studies from the inception of the database until October 2023.

A new cooperative control solution of subway BAS: an improved fuzzy PID control algorithm.

The building automation system (BAS) of a subway is the core component of monitoring and managing urban rail transit systems. For the current problems such as low control efficiency, insufficient accuracy, and poor stability of metro BAS, this article proposes a cooperative control framework based on an improved fuzzy proportional-integral-derivative (PID) algorithm. Firstly, the concept of an integrated supervisory control system (ISCS) for subways is introduced by summarizing the previously implemented engineering construction and combining it with advanced automation technology.

Ganoderma Lucidum polysaccharide peptide (GL-PP2): A potential therapeutic agent against sepsis-induced organ injury by modulating Nrf2/NF-κB pathways.

Sepsis, characterized by a severe immune response to infection, remains a leading cause of mortality, with few effective strategies to prevent organ damage. Targeting inflammation, oxidative stress, and apoptosis is crucial for improving outcomes and advancing sepsis management. We investigated the protective effects of Ganoderma Lucidum Polysaccharide Peptide 2 (GL-PP2) against sepsis-induced organ damage, focusing on immune regulation and kidney protection.

PanicleNeRF: Low-Cost, High-Precision In-Field Phenotyping of Rice Panicles with Smartphone.

The rice panicle traits substantially influence grain yield, making them a primary target for rice phenotyping studies. However, most existing techniques are limited to controlled indoor environments and have difficulty in capturing the rice panicle traits under natural growth conditions. Here, we developed PanicleNeRF, a novel method that enables high-precision and low-cost reconstruction of rice panicle three-dimensional (3D) models in the field based on the video acquired by the smartphone.

Dynamic 4D facial capture pipeline with appearance driven progressive retopology based on optical flow.

This paper presents a production-oriented 4D facial reconstruction pipeline designed to produce high-fidelity facial mesh sequences with a consistently structured topology, while preserving the wireframe structure specified by artists. We have designed and developed a compact, efficient, and fast optical capture system based on synchronized camera arrays for high-precision dynamic 3D facial imaging. Unlike prevailing methods that primarily concentrate on single-frame reconstruction, often reliant on labor-intensive manual annotation, our framework exploits the constraint of appearance consistency to autonomously establish feature correspondence and uphold temporal coherence within the mesh.

Self-Boosting Programmable Release of Multiple Therapeutic Agents by Activatable Heterodimeric Prodrug-Enzyme Assembly for Antitumor Therapy.

Endogenous stimuli-responsive prodrugs, due to their disease lesion specificity and reduced systemic toxicity, have been widely explored for antitumor therapy. However, reactive oxygen species (ROS) as classical endogenous stimuli in the tumor microenvironment (TME) are not enough to achieve the expected drug release. Herein, a ROS-activatable heterodimeric prodrug-loaded enzyme assembly is developed for self-boosting programmable release of multiple therapeutic agents.

Comprehensive geriatric assessment guided radiotherapy in elderly patients with locally advanced rectal cancer-exploratory results on nonoperative cohort of a multicenter prospective study.

Background: Chemoradiotherapy (CRT) is the main treatment for elderly patients with non-metastatic rectal cancer who are ineligible for or decline surgery, but the optimal modality remains unclear.

Objectives: This study was to validate the safety and efficacy of comprehensive geriatric assessment (CGA) guided radiotherapy in older patients.

Design: An exploratory analysis of a single-arm, multicenter, Phase II trial.

The Magnetic Resonance Image-Arterial Spin Labeling Characteristic of Nonketotic Hyperglycemic Hemichorea in an Elderly Type 2 Diabetic Female Patient.

Nonketotic hyperglycemia-induced hemichorea is a rare condition of type 2 diabetes. It is characterized by hyperglycemia with the symptom traced to the basal ganglion like hemichorea or hemiballism, with the hyperintensity within basal ganglion presented in computed tomography (CT) or hyper signal in T1-weighted magnetic resonance image (MRI). It was also confirmed with a relatively better prognosis in that the symptoms of these patients could be relieved after the alleviation of hyperglycemia.

Eosinophil extracellular traps drive T follicular helper cell differentiation via VIRMA-dependent MAF stabilization in bullous pemphigoid.

Background: Bullous pemphigoid (BP) is an autoimmune blistering disease characterized by the presence of pathogenic autoantibodies and a substantial influx of immune cells into skin lesions. However, the role of eosinophils in BP remains inadequately elucidated.

Objective: We sought to determine the pathologic involvement of eosinophils and eosinophil extracellular traps (EETs) in BP.

Inhibition of JNK/STAT3/NF-KB pathway-mediated migration and clonal formation of lung adenocarcinoma A549 cells by daphnetin.

Daphnetin, a coumarin derivative isolated from Daphne odorifera, has anti-tumor effects. The MAPK, STAT3, and NF-κB signaling pathways are closely related to the pathogenesis of lung cancer. To investigate the effect of daphnetin on anti-lung adenocarcinoma A549 cells and its mechanism.

Suppression of Visceral Nociception by Selective C-Fiber Transmission Block Using Temporal Interference Sinusoidal Stimulation.

Chronic visceral pain management remains challenging due to limitations in selective targeting of C-fiber nociceptors. This study investigates temporal interference stimulation (TIS) on dorsal root ganglia (DRG) as a novel approach for selective C-fiber transmission block. We employed (1) GCaMP6 recordings in mouse whole DRG using a flexible, transparent microelectrode array for visualizing L6 DRG neuron activation, (2) ex vivo single-fiber recordings to assess sinusoidal stimulation effects on peripheral nerve axons, (3) in vivo behavioral assessment measuring visceromotor responses (VMR) to colorectal distension in mice, including a TNBS-induced visceral hypersensitivity model, and (4) immunohistological analysis to evaluate immediate immune responses in DRG following TIS.

The association between living alone and depressive symptoms in older adults population: evidence from the China Health and Retirement Longitudinal Study.

Objective: The goal of this research was to reveal the association between living alone and depressive symptoms in older adults. It also aims to explore the mediating role of social activity and adult children's relationship satisfaction. Ultimately, the study seeks to add to the body of knowledge for lowering the risk of depression among older people and promoting positive aging.