Superconductivity in Metal Sulfides.

The exploration of high-temperature superconductors and the mechanisms underlying continues to present significant challenges in condensed matter physics. Identifying new potential superconducting platforms is critical for advancing our understanding of superconductivity and its interactions with other quantum states. Metal sulfides constitute a diverse family of materials that exhibit unique physical properties, with crystal structures that can be tailored from one-dimensional (1D) to three-dimensional (3D) by varying the metal-to-sulfur ratio.

Gasdermin D-dependent neutrophil extracellular traps exacerbate cytokine storm contributing to pyoderma gangrenosum pathogenesis.

Pyoderma gangrenosum (PG) is characterized by the agonizing necrotizing ulcers with non-infectious neutrophil infiltration. Neutrophil extracellular traps (NETs) represent one of the mechanisms of neutrophils activation, and gasdermin D (GSDMD) plays a regulatory role in NETs. In this study, we discovered that the serum levels of NETs were elevated in PG patients compared to healthy controls.

[Comparative Research on Regulatory Requirements of Radiotherapy Equipment Across Countries].

Objective: To lay a foundation for formulating clinical evaluation and regulatory policies regarding radiotherapy equipment in China.

Methods: Comprehensive retrieval and comparison of the regulatory requirements for radiotherapy equipment from regulatory agencies in the United States, the European Union, and China are conducted, and their similarities and differences are analyzed.

Results: For mature radiotherapy systems in the European and American regions, the comparison of performance parameters serves as an important basis for determining whether a product can be marketed.

Plasticized agarose films: A physicochemical, mechanical and thermal study.

Agarose uniquely forms moldable biodegradable films, making it a promising renewable material with exceptional biocompatibility, thermo-reversibility, and flexibility. However, agarose films lose most of their flexibility at low moisture content. One way to assuage this issue is to incorporate plasticizing agents.

Leveraging FDA Labeling Documents and Large Language Model to Enhance Annotation, Profiling, and Classification of Drug Adverse Events with AskFDALabel.

Background: Drug adverse events (AEs) represent a significant public health concern. US Food and Drug Administration (FDA) drug labeling documents are an essential resource for studying drug safety such as assessing a drug's likelihood to cause certain organ toxicities; however, the manual extraction of AEs is labor-intensive, requires specialized expertise, and is challenging to maintain, due to frequent updates of the labeling documents.

Objective: To automate the extraction of AE data from FDA drug labeling documents, we developed a workflow based on AskFDALabel, a large language model (LLM)-powered framework, and its demonstration in drug safety studies.

Polar topology in self-assembled PbTiO ferroelectric nano-islands.

The topological domains in ferroelectrics have garnered significant attention for their potential applications in nanoelectronics. However, current research is predominantly limited to rhombohedral BiFeO materials. To validate the universality of topological domains in non-rhombohedral ferroelectrics, it is crucial to explore the existence and characteristics of topological states in alternative material systems.

Evaluation of nationwide analysis surveillance for methicillin-resistant within Genomic Medicine Sweden.

National epidemiological investigations of microbial infections greatly benefit from the increased information gained by whole-genome sequencing (WGS) in combination with standardized approaches for data sharing and analysis. To evaluate the quality and accuracy of WGS data generated by different laboratories but analysed by joint pipelines to reach a national surveillance approach. A national methicillin-resistant (MRSA) collection of 20 strains was distributed to nine participating laboratories that performed in-house procedures for WGS.

Interspecies interactions mediated by arginine metabolism enhance the stress tolerance of against .

Colorectal cancer (CRC) is a common cancer accompanied by microbiome dysbiosis. Exploration of probiotics against oncogenic microorganisms is promising for CRC treatment. Here, differential microorganisms between CRC and healthy control were analyzed.

Angiotensin type 1 and type 2 receptors-induced mitochondrial dysfunction promotes ferroptosis in cardiomyocytes.

Previous studies suggest that ferroptosis is involved in cardiovascular diseases. The aim of the present study is to investigate the causal relationship between angiotensin II type 1 and type 2 receptors (ATR) activities and mitochondrial dysfunction in induction of cardiomyocyte ferroptosis. Human AC16 cardiomyocytes were first pre-treated with an ATR blockers, before stimulated with angiotensin II (Ang II) for 24 h.

Application of flow cytometry immunophenotypic analysis for the diagnosis of mature B-cell lymphomas/leukemias.

Flow cytometry immunophenotyping (FCI) is an important and indispensable tool in the diagnosis of mature B-cell lymphomas/leukemias, particularly for small fine needle aspiration and needle core biopsy specimens which are becoming increasingly popular for diagnostic purposes. FCI has several advantages. Given its multiparametric nature, FCI can analyze the expression of multiple antigens simultaneously on the same cell of interest, qualitatively and quantitively.

Burkitt lymphoma.

Burkitt lymphoma is a mature aggressive B-cell neoplasm with distinctive clinical and morphologic features, a germinal center B-cell immunophenotype, a high proliferation index and MYC rearrangement with an immunoglobulin gene partner. Initially described in equatorial Africa by a surgeon, Denis Burkitt, African (endemic) Burkitt lymphoma was the first neoplasm shown to be associated with a virus, Epstein-Barr virus (EBV), and the first neoplasm shown to be associated with a chromosomal translocation, IGH::MYC. In this article, we provide a brief historical introduction of Burkitt lymphoma, followed by a review of all aspects of this neoplasm including pathogenesis, clinical presentation, morphology, immunophenotype, cytogenetics and molecular findings.

Tanshinone IIA, a component of Salvia miltiorrhiza Bunge, attenuated sepsis-induced liver injury via the SIRT1/Sestrin2/HO-1 signaling pathway.

Ethnopharmacological Relevance: As a traditional Chinese medicine, Salvia miltiorrhiza Bunge has been widely used to treat ischemic and inflammation-related diseases for more than 2000 years. S. miltiorrhiza Bunge has hepatoprotective effects, but the underlying mechanism is not fully understood.

Density-wave-like gap evolution in LaNiO under high pressure revealed by ultrafast optical spectroscopy.

Density wave (DW) order is believed to be correlated with superconductivity in the recently discovered high-temperature superconductor LaNiO. However, experimental investigations of its evolution under high pressure are still lacking. Here, we explore the quasiparticle dynamics in bilayer nickelate LaNiO single crystals using ultrafast optical pump-probe spectroscopy under high pressures up to 34.

Optical Genome Mapping for Detection of -Another Tool in Our Toolbox.

fusion is mostly derived from a reciprocal translocation t(9;22)(q34.1;q11.2) and is rarely caused by insertion.

Successful Live Birth Outcome in A Patient with Empty Follicle Syndrome: A Case Report and Literature Review.

Here, we report on a rare case of a successful live birth in a patient with empty follicle syndrome. A 35-year-old woman with ovulatory disorder and a 4-year history of primary infertility conducted in vitro fertilization-embryo transfer (IVF-ET) treatment in our hospital. The patient experienced six controlled ovarian stimulation cycles.

Non-surgical treatment for tandem spinal stenosis: a systematic review protocol.

Background: Tandem Spinal Stenosis (TSS) is a disease characterised by the narrowing of the spinal canal in two or more non-adjacent areas of the spine, often affecting both the cervical and lumbar vertebrae. Doctors and patients increasingly favour non-surgical treatments that have the function of relieving symptoms and improving outcomes. This systematic review aims to evaluate the effectiveness and safety of non-surgical therapies for TSS and comprehensively summarise existing evidence.

PDeT: A Progressive Deformable Transformer for Photovoltaic Panel Defect Segmentation.

Defects in photovoltaic (PV) panels can significantly reduce the power generation efficiency of the system and may cause localized overheating due to uneven current distribution. Therefore, adopting precise pixel-level defect detection, i.e.

Ultrafast dynamics evidence of strong coupling superconductivity in LaH.

Recently, tremendous research interest has been aroused in clathrate superhydrides. However, their microscopic properties, especially the superconducting (SC) gap and electron-phonon coupling (EPC) strength, are largely unexplored experimentally. Here, we investigate the time-resolved ultrafast spectroscopy of a superconductor LaH under an ultrahigh pressure of 165 GPa.

Multi-omics PGT: re-evaluation of euploid blastocysts for implantation potential based on RNA sequencing.

Study Question: In addition to chromosomal euploidy, can the transcriptome of blastocysts be used as a novel predictor of embryo implantation potential?

Summary Answer: This retrospective analysis showed that based on differentially expressed genes (DEGs) between euploid blastocysts which resulted and did not result in a clinical pregnancy, machine learning models could help improve implantation rates by blastocyst optimization.

What Is Known Already: Embryo implantation is a multifaceted process, with implantation loss and pregnancy failure related not only to blastocyst euploidy but also to the intricate dialog between blastocyst and endometrium. Although in vitro studies have revealed the characteristics of trophectoderm (TE) differentiation in implanted blastocysts and the function of TE placentation at the implantation site, the precise molecular mechanisms of embryo implantation and their clinical application remain to be fully elucidated.